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Information on SUBCLASS 5.53.1
Subclass Accession number: 7515
Subclass: 5.53.1 PSSM
Type: EH beta-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 3

Average sequence ID (%) : 30.2 +/- 33.9
Average RMSD (Å) : 0.533 +/- 0.058

Consensus geometry
d (Å): 13 delta (°): 45-90 theta (°): 135-180 rho (°): 180-225
Consensus Sequence: hpphXppXX
(φψ)-conformation: pblaaabaa
Pattern: [KL][KL][LP][ST][HR][PV]x[QR][NS]x[IPT][HL][AF][EK][QR][AT][LY][ER][EF][AL]x
Conservation:-0.787-0.787-1.0340.8511.338-0.053-0.5361.2181.822-1.197-1.595-0.275-0.6811.2181.2180.3810.5370.628-0.903-0.565-0.797
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1onw_A_2261onw   A226246LLPTHVNRNVPLFEQALEFAREEEE-GGGSHHHHHHHHHHHHxbwbvaaabaaaaaaaaaaaa
1ove_A_481ove   A5373KKLSRPFQSIIHAKRTYRELREEEESTTSSHHHHHHHHHHHHbxxxlaaabaaaaaaaaaaaa
1pmn_A_881pmn   A93113KKLSRPFQNQTHAKRAYRELVEEEESTTSSHHHHHHHHHHHHbbbxlaaabaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1onw_A_2261onw   A     KCXLYSINE NZ-CARBOXYLIC ACID T - 229
1onw_A_2261onw   A     ZNZINC ION T - 229
1onw_A_2261onw   A     KCXLYSINE NZ-CARBOXYLIC ACID H - 230
1onw_A_2261onw   A     ZNZINC ION H - 230
1onw_A_2261onw   A     ZNZINC ION R - 233
1ove_A_481ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE A - 51
1ove_A_481ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE V - 52
1ove_A_481ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE K - 53
1ove_A_481ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE E - 71
1ove_A_481ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE L - 75
1pmn_A_881pmn   A     984CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE A - 91
1pmn_A_881pmn   A     984CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE I - 92
1pmn_A_881pmn   A     984CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE K - 93

Clusters included in this Subclass
CLUSTER: EH.4.271