ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 21.1.1

Subclass Accession number: 7720
Subclass: 21.1.1

Type: EH beta-alpha
DB: ArchDB-EC

Image coordinates:

Consensus coordinates:

Number of loops: 3

Average sequence ID (%) : 60.7 +/- -7.6
Average RMSD (Å) : 0.200 +/- 0.000

Consensus geometry

d (Å): 13

delta (°): 45-90

theta (°): 135-180

rho (°): 180-225

Consensus Sequence:	hDhDhhDPXXXPhXGTPVhGGLpYR
(φψ)-conformation:	bpaaappaaabapbabpbplpppaa

Pattern:	[IV]	[H]	[L]	[S]	[FL]	[D]	[ILV]	[D]	[AG]	[FL]	[D]	[P]	[STV]	x	[AT]	[P]	[AG]	[TV]	[G]	[T]	[P]	[V]	[IV]	[G]	[G]	[L]	[ST]	[Y]	[R]	[E]	[GS]	[HLM]	[LY]	[AI]	[AMT]	[E]	[EM]	[IL]	x
Conservation:	-0.193	2.011	0.049	0.049	-0.612	1.030	-0.605	1.030	-0.546	-0.735	1.030	1.520	-1.313	-1.803	-0.815	1.520	-0.727	-0.765	1.030	0.540	1.520	0.049	-0.193	1.030	1.030	0.049	-0.484	1.520	0.540	0.540	-0.612	-1.313	-0.701	-1.160	-1.368	0.540	-1.153	-0.434	-1.095

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1d3v_A_227	1d3v	A	227	265	IHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIY	EEEEEEGGGB-TTT---SSS--SS-B-HHHHHHHHHHHH	bbbbxxaaaxxaaabaxbabwbxvxxxaaaaaaaaaaaa
1pq3_A_246	1pq3	A	246	284	IHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIH	EEEEEEGGGB-TTT--SBSS--SS-B-HHHHHHHHHHHH	bbbxbxaaaxxaaabaxbabpbxvxxxaaaaaaaaaaaa
2cev_A_220	2cev	A	221	259	VHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLA	EEEEEEGGGB-TTT----SS--SS-B-HHHHHHHHHHHH	bxbbbxaaaxxaaabaxbabxbxvxxxaaaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1d3v_A_227	1d3v	A	MNMANGANESE (II) ION	D - 232
1d3v_A_227	1d3v	A	ABH2(S)-AMINO-6-BORONOHEXANOIC ACID	D - 232
1d3v_A_227	1d3v	A	MNMANGANESE (II) ION	D - 234
1d3v_A_227	1d3v	A	ABH2(S)-AMINO-6-BORONOHEXANOIC ACID	D - 234
1d3v_A_227	1d3v	A	MNMANGANESE (II) ION	G - 235
1d3v_A_227	1d3v	A	MNMANGANESE (II) ION	T - 246
1d3v_A_227	1d3v	A	ABH2(S)-AMINO-6-BORONOHEXANOIC ACID	T - 246
1pq3_A_246	1pq3	A	MNMANGANESE (II) ION	D - 251
1pq3_A_246	1pq3	A	S2CS-2-(BORONOETHYL)-L-CYSTEINE	D - 251
1pq3_A_246	1pq3	A	MNMANGANESE (II) ION	D - 253
1pq3_A_246	1pq3	A	S2CS-2-(BORONOETHYL)-L-CYSTEINE	D - 253
1pq3_A_246	1pq3	A	MNMANGANESE (II) ION	A - 254
1pq3_A_246	1pq3	A	S2CS-2-(BORONOETHYL)-L-CYSTEINE	T - 263
1pq3_A_246	1pq3	A	MNMANGANESE (II) ION	T - 265
1pq3_A_246	1pq3	A	S2CS-2-(BORONOETHYL)-L-CYSTEINE	T - 265
2cev_A_220	2cev	A	MNMANGANESE (II) ION	D - 226
2cev_A_220	2cev	A	MNMANGANESE (II) ION	D - 228
2cev_A_220	2cev	A	MNMANGANESE (II) ION	G - 229
2cev_A_220	2cev	A	MNMANGANESE (II) ION	T - 240
2cev_A_220	2cev	A	GAIGUANIDINE	G - 244
2cev_A_220	2cev	A	GAIGUANIDINE	Y - 248
2cev_A_220	2cev	A	GAIGUANIDINE	R - 249
2cev_A_220	2cev	A	GAIGUANIDINE	E - 250
2cev_A_220	2cev	A	GAIGUANIDINE	H - 252
2cev_A_220	2cev	A	GAIGUANIDINE	L - 253
2cev_A_220	2cev	A	GAIGUANIDINE	E - 256

PDB Site Annotated loops in this subclass

Loop	PDB	Chain	Site	Residue
2cev_A_220	2cev	A	MNAMN 301 BOUND TO HIS 99 ND1, ASP 122 OD2, ASP 126 OD2, ASP 226 OD2, A BRIDGING WATER HOH1 AND A TERMINAL WATER HOH MN 302 BOUND TO HIS 124 ND1, ASP 122 OD1, ASP 226 OD2, ASP 228 OD1, ASP 228 OD2 AND THE BRIDGING WATER HOH1	D - 226
2cev_A_220	2cev	A	MNAMN 301 BOUND TO HIS 99 ND1, ASP 122 OD2, ASP 126 OD2, ASP 226 OD2, A BRIDGING WATER HOH1 AND A TERMINAL WATER HOH MN 302 BOUND TO HIS 124 ND1, ASP 122 OD1, ASP 226 OD2, ASP 228 OD1, ASP 228 OD2 AND THE BRIDGING WATER HOH1	D - 228

Clusters included in this Subclass