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Information on SUBCLASS 12.1.1
Subclass Accession number: 853
Subclass: 12.1.1 PSSM
Type: HA beta-beta hairpin
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4 (>75 %)  3.4 (>75 %)  3.4.21 (>75 %)  3.4.21 (>75 %)  3.4.21 (>75 %)  
GO : GO:0004175 (>75 %)  GO:0004175 (>75 %)  GO:0004252 (>75 %)  GO:0004252 (>75 %)  GO:0004252 (>75 %)  GO:0005509 (>75 %)  GO:0008233 (>75 %)  GO:0008233 (>75 %)  GO:0008236 (>75 %)  GO:0008236 (>75 %)  GO:0008236 (>75 %)  
SCOP : 50493 (>75 %)  50493 (>75 %)  50493 (>75 %)  50494 (>75 %)  50494 (>75 %)  50494 (>75 %)  50514 (>75 %)  50514 (>75 %)  50514 (>75 %)  
 Number of loops: 4

Average sequence ID (%) : 28.0 +/- 21.3
Average RMSD (Å) : 0.325 +/- 0.050

Consensus geometry
d (Å): 1 delta (°): 90-135 theta (°): 135-180 rho (°): 0-45
Consensus Sequence: hXpXphpcXXhpXDhh
(φψ)-conformation: bppaapbaaalplpbb
Pattern: [ADQ][FHV][HIY][DENT][AV][AER]x[AIV][IV]x[HN][KNP][NQR][FY][DNT][DGKQ]x[LT][ILY][DQR]x[D][IV][AM][LV][ILV][HKQR][L]
Conservation:-0.697-1.004-0.609-0.467-0.106-0.561-1.429-0.3850.982-1.1231.859-0.4970.0121.813-0.055-0.992-1.3410.126-0.275-0.3550.0152.6780.982-0.3080.3930.312-0.2491.280
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1cgh_A_811cgh   A81108QHITARRAIRHPQYNQRTIQNDIMLLQLEEEEEEEEEE-TT-BTTTTBS--EEEEEbbbxxabbxxpaapbaaavxlxbbbbxx
1eq9_A_791eq9   A79106DVYDVEDAVVNKNYDDFLLRNDVALVHLEEEEEEEEEE-TT-BTTTTB---EEEEExbbxxabbbxpaaxbaaalblxbbbbxx
1fjs_A_811fjs   A81108AVHEVEVVIKHNRFTKETYDFDIAVLRLEEEEEEEEEE-TT-BTTTTBT--EEEEEbbbxxabbbxxaaxbaaavxvxbbbbxx
1s83_A_811s83   A81108QFINAAKIITHPNFNGNTLDNDIMLIKLEEEEEEEEEE-TT--TTT-TT--EEEEEbbbxxabbbxpaapbaaavxlxbbbbxx
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1cgh_A_811cgh   A     SINSUCCINIC ACID I - 99
1cgh_A_811cgh   A     PPHPHENYLALANINE PHOSPHINIC ACID D - 102
1fjs_A_811fjs   A     GOLGLYCEROL V - 88
1fjs_A_811fjs   A     GOLGLYCEROL I - 89
1fjs_A_811fjs   A     GOLGLYCEROL K - 90
1fjs_A_811fjs   A     GOLGLYCEROL H - 91
1fjs_A_811fjs   A     GOLGLYCEROL N - 92
1fjs_A_811fjs   A     GOLGLYCEROL R - 93
1fjs_A_811fjs   A     Z34N-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-3,5-DIFLUORO-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL) PHENOXY]PYRIDIN-4-YL]-N-METHYLGLYCINE T - 95
1fjs_A_811fjs   A     Z34N-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-3,5-DIFLUORO-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL) PHENOXY]PYRIDIN-4-YL]-N-METHYLGLYCINE K - 96
1fjs_A_811fjs   A     Z34N-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-3,5-DIFLUORO-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL) PHENOXY]PYRIDIN-4-YL]-N-METHYLGLYCINE E - 97
1fjs_A_811fjs   A     Z34N-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-3,5-DIFLUORO-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL) PHENOXY]PYRIDIN-4-YL]-N-METHYLGLYCINE T - 98
1fjs_A_811fjs   A     Z34N-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-3,5-DIFLUORO-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL) PHENOXY]PYRIDIN-4-YL]-N-METHYLGLYCINE Y - 99
1s83_A_811s83   A     CACALCIUM ION F - 82
1s83_A_811s83   A     MGMAGNESIUM ION F - 82
1s83_A_811s83   A     4HA4-HYDROXYBUTAN-1-AMINIUM L - 99
1s83_A_811s83   A     4HA4-HYDROXYBUTAN-1-AMINIUM D - 102

Clusters included in this Subclass
CLUSTER: HA.12.2