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Information on SUBCLASS 10.8.1
Subclass Accession number: 8751
Subclass: 10.8.1 PSSM
Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 2.7 (>75 %)  2.7.1 (>75 %)  2.7.1.37
SCOP : 56111 (>75 %)  56112 (>75 %)  88854 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 52.9 +/- 6.8
Average RMSD (Å) : 0.533 +/- 0.153

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: XphpHENhIGhXDh
(φψ)-conformation: aapbbaabpbpabb
Pattern: x[ILT][FHY][AC][KQ][R][AT][LY][R][E][IL][KR][IL][L][KL][HR][FM][KR][H][E][N][IV][I][G][IL]x[D][IV][FI]
Conservation:-1.773-1.303-0.229-0.322-0.3550.846-0.661-0.7290.8460.846-0.359-0.055-0.3590.241-1.383-0.125-0.528-0.0072.6590.8461.450-0.0590.2411.450-0.359-1.6051.450-0.059-0.606
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1cm8_A_651cm8   A6593ELFAKRAYRELRLLKHMRHENVIGLLDVFHHHHHHHHHHHHHHHH--BTTB---SEEEaaaaaaaaaaaaaaaaxbbaabpbxabbb
1ove_A_621ove   A6290IIHAKRTYRELRLLKHMKHENVIGLLDVFHHHHHHHHHHHHHHHH---TTB---SEEEaaaaaaaaaaaaaaaaxbbaabxbxabbb
1pme_*_621pme   -6290QTYCQRTLREIKILLRFRHENIIGINDIIHHHHHHHHHHHHHHHH---TTB----EEEaaaaaaaaaaaaaaaaxbbaabxbxabbb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1cm8_A_651cm8   A     TPOPHOSPHOTHREONINE L - 66
1cm8_A_651cm8   A     TPOPHOSPHOTHREONINE K - 69
1cm8_A_651cm8   A     TPOPHOSPHOTHREONINE R - 70
1cm8_A_651cm8   A     PTRO-PHOSPHOTYROSINE R - 70
1cm8_A_651cm8   A     TPOPHOSPHOTHREONINE R - 73
1cm8_A_651cm8   A     MGMAGNESIUM ION E - 74
1cm8_A_651cm8   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER E - 74
1cm8_A_651cm8   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER I - 87
1ove_A_621ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE E - 71
1ove_A_621ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE L - 75
1ove_A_621ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE I - 84
1ove_A_621ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE G - 85
1ove_A_621ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE L - 86
1pme_*_621pme   *     5774-[5-(4-FLUORO-PHENYL)-2-[4-METHANESULFINYL-PHENYL]-3H -IMIDAZOL-4-YL]-PYRIDINE E - 71
1pme_*_621pme   *     5774-[5-(4-FLUORO-PHENYL)-2-[4-METHANESULFINYL-PHENYL]-3H -IMIDAZOL-4-YL]-PYRIDINE L - 75
1pme_*_621pme   *     5774-[5-(4-FLUORO-PHENYL)-2-[4-METHANESULFINYL-PHENYL]-3H -IMIDAZOL-4-YL]-PYRIDINE I - 84
1pme_*_621pme   *     5774-[5-(4-FLUORO-PHENYL)-2-[4-METHANESULFINYL-PHENYL]-3H -IMIDAZOL-4-YL]-PYRIDINE G - 85
1pme_*_621pme   *     5774-[5-(4-FLUORO-PHENYL)-2-[4-METHANESULFINYL-PHENYL]-3H -IMIDAZOL-4-YL]-PYRIDINE I - 86
1pme_*_621pme   *     5774-[5-(4-FLUORO-PHENYL)-2-[4-METHANESULFINYL-PHENYL]-3H -IMIDAZOL-4-YL]-PYRIDINE D - 88

Clusters included in this Subclass
CLUSTER: HE.9.44