Logo
Information on SUBCLASS 2.2.1
Subclass Accession number: 8917
Subclass: 2.2.1 PSSM
Type: HH alpha-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 76

Average sequence ID (%) : 11.5 +/- 13.5
Average RMSD (Å) : 0.587 +/- 0.224

Consensus geometry
d (Å): 9 delta (°): 90-135 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: XXXpXX
(φψ)-conformation: aalpaa
Pattern: xxxxxx[adegknqrs][cdeknqrsw]x[adegknqrst]x[acfilmvwy]x
Conservation:-0.536-0.869-0.155-0.536-0.4340.0252.3431.556-1.175-0.049-0.4810.820-0.508
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a17_*_221a17   -3648NDYFKAKDYENAIHHHHHTT-HHHHHaaaaaavxaaaaa
1a17_*_621a17   -7082LAYLRTECYGYALHHHHHTT-HHHHHaaaaaavxaaaaa
1a17_*_961a17   -104116ASNMALGKFRAALHHHHHTT-HHHHHaaaaaavxaaaaa
1ah7_*_861ah7   -98110GESYKNKDMKQAFHHHHHTT-HHHHHaaaaaavxaaaaa
1am7_A_1051am7   A105117LPMIDRGDIRQAIHHHHHHT-HHHHHaaaaaavxaaaaa
1b4u_A_681b4u   A7183KAAVLARDYNAMIHHHHHHT-HHHHHaaaaaalbaaaaa
1bpy_A_131bpy   A2537FEKNVSQAIHKYNHHHHTT--HHHHHaaaaaavbaaaaa
1bsg_*_1191bsg   -124136EVSITASDNCAANHHHHHS--HHHHHaaaaaalxaaaaa
1bue_A_1191bue   A124136AAALQYSDNGATNHHHHHS--HHHHHaaaaaalpaaaaa
1ca1_*_941ca1   -106118RYEWQRGNYKQATHHHHHTT-HHHHHaaaaaavxaaaaa
1cb8_A_1731cb8   A185197YRALLTSDEALLSHHHHHTT-HHHHHaaaaaalxaaaaa
1clc_*_3601clc   -369381EMWETLGDEEYLRHHHHHH--HHHHHaaaaaavpaaaaa
1dl2_A_2121dl2   A217229YLAYLTGNRTYWEHHHHHHT-HHHHHaaaaaavxaaaaa
1dl2_A_2751dl2   A283295KQYLLTHETLYYDHHHHHH--HHHHHaaaaaavxaaaaa
1dl2_A_4351dl2   A442454FMYHLSHDHKYREHHHHHH--THHHHaaaaaavxaaaaa
1dym_A_3121dym   A313325EFCEATGSRKYMEHHHHHTT-HHHHHaaaaaavxaaaaa
1es5_A_851es5   A90102YGLMLPSGCDAAYHHHHSS--HHHHHaaaaaavxaaaaa
1f1s_A_4271f1s   A439451IEGLLRKDNTIIEHHHHHTT-HHHHHaaaaaalbaaaaa
1f6k_A_2091f6k   A220232FELTKAGKLKEALHHHHHTT-HHHHHaaaaaavxaaaaa
1fo3_A_2891fo3   A296308DTMWILGLRKEFEHHHHHTT-HHHHHaaaaaavxaaaaa
1fo3_A_3281fo3   A341353SAYHLSGDSLFLRHHHHHH--HHHHHaaaaaavxaaaaa
1fp3_A_1221fp3   A133145ELWRVTAEARYQSHHHHHH--HHHHHaaaaaavxaaaaa
1fp3_A_2461fp3   A258270RHSSRSGDAKLRAHHHHHTT-HHHHHaaaaaalxaaaaa
1fp3_A_3131fp3   A325337MGYSESGDPALLRHHHHHH--HHHHHaaaaaavxaaaaa
1g99_A_2841g99   A288300DEAASKGNRKAELHHHHHTT-HHHHHaaaaaavxaaaaa
1g9g_A_4951g9g   A507519YYAAKSGDETSRQHHHHHH--HHHHHaaaaaavxaaaaa
1h72_C_1961h72   C210222VYALYNKDKSLFGHHHHHTT-HHHHHaaaaaalbaaaaa
1hkx_A_3411hkx   A358370IEAISNGDFESYTHHHHHTT-HHHHHaaaaaavxaaaaa
1hl2_A_2101hl2   A221233VKALKEGDIQTAQHHHHHTT-HHHHHaaaaaavxaaaaa
1hzo_A_1191hzo   A124136AATLQYSDNTAMNHHHHHT--HHHHHaaaaaavxaaaaa
1i5n_A_371i5n   A5264GGAGTFGFTILQEHHHHHTT-HHHHHaaaaaavxaaaaa
1idp_A_131idp   A2739ADSYDSKDWDRLRHHHHHHT-HHHHHaaaaaalxaaaaa
1ihg_A_2161ihg   A231243NTFFKSQNWEMAIHHHHHTT-HHHHHaaaaaalxaaaaa
1ihg_A_2691ihg   A281293ACKLKMSDWQGAVHHHHHTT-HHHHHaaaaaalxaaaaa
1ihg_A_3071ihg   A315327QGWQGLKEYDQALHHHHHTT-HHHHHaaaaaalxaaaaa
1iib_A_811iib   A8193SLLYGKVDGLGVLHHHHHTT-HHHHHaaaaaalxaaaaa
1itw_A_6041itw   A616628HLGNAYKNPKALVHHHHHTT-HHHHHaaaaaalbaaaaa
1iw0_A_1041iw0   A114126EEIRDNVDGPALVHHHHHHT-HHHHHaaaaaalxaaaaa
1j5w_A_2061j5w   A221233YRLVEKNLYLPAYHHHHHTT-HHHHHaaaaaavxaaaaa
1jms_A_1661jms   A177189ENDELRENEGSCLHHHHHTT-HHHHHaaaaaalbaaaaa
1jqn_A_301jqn   A4254SKSSRAGNDANRQHHHHHTT-HHHHHaaaaaagxaaaaa
1k28_A_2931k28   A296308LTAMLAGDWEKAYHHHHHTT-HHHHHaaaaaavxaaaaa
1k4g_A_3281k4g   A332344HHLIRAGEILGAMHHHHHTT-HHHHHaaaaaavxaaaaa
1kho_A_941kho   A106118RYEWKRGNYKQATHHHHHTT-HHHHHaaaaaavxaaaaa
1kkt_A_3331kkt   A340352LGGTVLDRQDFIDHHHHHHT-HHHHHaaaaaavbaaaaa
1kkt_A_4091kkt   A416428YAHRVTGKEIYRDHHHHHH--HHHHHaaaaaavxaaaaa
1kkt_A_811kkt   A88100STAVIMGKADVVNHHHHHHT-HHHHHaaaaaavxaaaaa
1klx_A_1131klx   A121133EKACRLGSEDACGHHHHHTT-HHHHHaaaaaagxaaaaa
1klx_A_411klx   A4961SKACELNSGNGCRHHHHHTT-HHHHHaaaaaavxaaaaa
1klx_A_771klx   A8597SKACGLNDQDGCLHHHHHTT-HHHHHaaaaaavxaaaaa
1kt0_A_2611kt0   A276288TVYFKGGKYMQAVHHHHHTT-HHHHHaaaaaavxaaaaa
1kt0_A_3061kt0   A325337MCYLKLREYTKAVHHHHHTT-HHHHHaaaaaalbaaaaa
1kt0_A_3511kt0   A359371EAQLLMNEFESAKHHHHHTT-HHHHHaaaaaavxaaaaa
1l3s_A_6571l3s   A661673VLAHIAEDDNLMEHHHHHHT-HHHHHaaaaaalxaaaaa
1l5j_A_1281l5j   A133145EEKAKAGNEYAKQHHHHHTT-HHHHHaaaaaagxaaaaa
1lw9_A_1151lw9   A118130LRMLQQKRWDEAAHHHHHTT-HHHHHaaaaaavbaaaaa
1lwd_A_3301lwd   A342354HRGKLDGNQDLIRHHHHHHT-HHHHHaaaaaavxaaaaa
1mfo_A_1191mfo   A124136QAALQRSDNTAANHHHHHS--HHHHHaaaaaalpaaaaa
1n7o_A_3471n7o   A359371IAGLLRKDDQEISHHHHHTT-HHHHHaaaaaalbaaaaa
1o0y_A_1221o0y   A122134VGMLKAKEWEYVYHHHHHTT-HHHHHaaaaaavxaaaaa
1ocv_A_41ocv   A1527VAALNAGDLDGIVHHHHHHT-HHHHHaaaaaavxaaaaa
1oh0_A_61oh0   A1729IELVDVGDIEAIVHHHHHHT-HHHHHaaaaaavxaaaaa
1pb1_A_3541pb1   A362374MMLRHMGWTEAADHHHHHTT-HHHHHaaaaaavxaaaaa
1q0s_A_841q0s   A92104EDYNKTRDPLLLYHHHHHH--HHHHHaaaaaavxaaaaa
1qsa_A_1541qsa   A162174RLAMKAGNTGLVTHHHHHTT-HHHHHaaaaaavxaaaaa
1qsa_A_2851qsa   A293305RMALGTGDRRGLNHHHHHHT-HHHHHaaaaaavxaaaaa
1qsa_A_31qsa   A1426KQAWDNRQMDVVEHHHHHTT-HHHHHaaaaaavxaaaaa
1qsa_A_3191qsa   A327339DLLLERGREAEAKHHHHHTT-HHHHHaaaaaavxaaaaa
1qsa_A_3831qsa   A389401RELMYWNLDNTARHHHHHTT-HHHHHaaaaaalxaaaaa
1qsa_A_4131qsa   A421433RYAFNNQWWDLSVHHHHHTT-HHHHHaaaaaavxaaaaa
2a0b_*_7072a0b   -719731GAAGSVGLRHLQQHHHHHTT-HHHHHaaaaaavxaaaaa
2ayq_A_2942ayq   A303315MLRYSFGLEKEAAHHHHTS--HHHHHaaaaaavxaaaaa
2kfn_A_7092kfn   A713725IMAHLSRDKGLLTHHHHHTT-HHHHHaaaaaalxaaaaa
2occ_C_1292occ   C148160HHSLMEGDRKHMLHHHHHTT-HHHHHaaaaaavxaaaaa
2ovw_A_3122ovw   A313325KYCAATGANEYMRHHHHHTT-HHHHHaaaaaavxaaaaa
3ygs_P_703ygs   P7688SCLEDTGQDMLASHHHHTTT-HHHHHaaaaaavxaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ah7_*_861ah7   *     ZNZINC ION H - 118
1ah7_*_861ah7   *     ZNZINC ION Y - 119
1ah7_*_861ah7   *     ZNZINC ION G - 121
1ah7_*_861ah7   *     ZNZINC ION D - 122
1am7_A_1051am7   A     TRNNZ2-TRYPTOPHAN C - 120
1bpy_A_131bpy   A     DCT2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE R - 40
1ca1_*_941ca1   *     ZNZINC ION H - 126
1ca1_*_941ca1   *     CDCADMIUM ION H - 126
1ca1_*_941ca1   *     ZNZINC ION G - 129
1ca1_*_941ca1   *     ZNZINC ION D - 130
1ca1_*_941ca1   *     CDCADMIUM ION D - 130
1clc_*_3601clc   *     CACALCIUM ION A - 360
1clc_*_3601clc   *     CACALCIUM ION D - 361
1clc_*_3601clc   *     CACALCIUM ION D - 362
1dl2_A_2121dl2   A     NAGN-ACETYL-D-GLUCOSAMINE N - 224
1dl2_A_2121dl2   A     NAGN-ACETYL-D-GLUCOSAMINE T - 226
1dl2_A_2121dl2   A     NAGN-ACETYL-D-GLUCOSAMINE Y - 227
1dl2_A_2121dl2   A     NAGN-ACETYL-D-GLUCOSAMINE L - 230
1dl2_A_2751dl2   A     CACALCIUM ION S - 276
1dl2_A_2751dl2   A     CACALCIUM ION E - 279
1dl2_A_4351dl2   A     CACALCIUM ION E - 435
1dl2_A_4351dl2   A     GOLGLYCEROL E - 435
1dl2_A_4351dl2   A     CACALCIUM ION E - 438
1f6k_A_2091f6k   A     GOLGLYCEROL T - 223
1f6k_A_2091f6k   A     GOLGLYCEROL K - 224
1f6k_A_2091f6k   A     GOLGLYCEROL A - 225
1f6k_A_2091f6k   A     GOLGLYCEROL G - 226
1f6k_A_2091f6k   A     GOLGLYCEROL K - 227
1f6k_A_2091f6k   A     GOLGLYCEROL L - 228
1f6k_A_2091f6k   A     GOLGLYCEROL K - 229
1f6k_A_2091f6k   A     GOLGLYCEROL E - 230
1f6k_A_2091f6k   A     GOLGLYCEROL A - 231
1fo3_A_3281fo3   A     KIFKIFUNENSINE F - 329
1fo3_A_3281fo3   A     KIFKIFUNENSINE E - 330
1fo3_A_3281fo3   A     KIFKIFUNENSINE I - 333
1fo3_A_3281fo3   A     KIFKIFUNENSINE R - 334
1g99_A_2841g99   A     ADPADENOSINE-5'-DIPHOSPHATE F - 284
1g99_A_2841g99   A     ADPADENOSINE-5'-DIPHOSPHATE R - 285
1g99_A_2841g99   A     ADPADENOSINE-5'-DIPHOSPHATE D - 286
1g99_A_2841g99   A     ADPADENOSINE-5'-DIPHOSPHATE D - 288
1hkx_A_3411hkx   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE D - 342
1hkx_A_3411hkx   A     TBRHEXATANTALUM DODECABROMIDE D - 342
1hkx_A_3411hkx   A     TBRHEXATANTALUM DODECABROMIDE T - 343
1hkx_A_3411hkx   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE R - 346
1hkx_A_3411hkx   A     TBRHEXATANTALUM DODECABROMIDE R - 346
1hzo_A_1191hzo   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID Y - 129
1hzo_A_1191hzo   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID S - 130
1i5n_A_371i5n   A     MSESELENOMETHIONINE I - 43
1i5n_A_371i5n   A     MSESELENOMETHIONINE A - 46
1i5n_A_371i5n   A     MSESELENOMETHIONINE A - 47
1i5n_A_371i5n   A     MSESELENOMETHIONINE I - 50
1i5n_A_371i5n   A     MSESELENOMETHIONINE L - 62
1i5n_A_371i5n   A     MSESELENOMETHIONINE E - 64
1i5n_A_371i5n   A     MSESELENOMETHIONINE T - 65
1i5n_A_371i5n   A     MSESELENOMETHIONINE T - 66
1i5n_A_371i5n   A     MSESELENOMETHIONINE H - 67
1ihg_A_2161ihg   A     GOLGLYCEROL R - 251
1ihg_A_2161ihg   A     GOLGLYCEROL E - 254
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE Y - 130
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE V - 131
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE R - 132
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 134
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE G - 135
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE D - 136
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE S - 138
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE G - 139
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE G - 140
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE V - 142
1iw0_A_1041iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE I - 143
1j5w_A_2061j5w   A     MSESELENOMETHIONINE F - 213
1j5w_A_2061j5w   A     MSESELENOMETHIONINE Y - 216
1j5w_A_2061j5w   A     MSESELENOMETHIONINE E - 217
1j5w_A_2061j5w   A     MSESELENOMETHIONINE F - 220
1j5w_A_2061j5w   A     MSESELENOMETHIONINE Y - 221
1j5w_A_2061j5w   A     MSESELENOMETHIONINE V - 224
1j5w_A_2061j5w   A     MSESELENOMETHIONINE D - 234
1j5w_A_2061j5w   A     MSESELENOMETHIONINE Y - 235
1j5w_A_2061j5w   A     MSESELENOMETHIONINE I - 236
1j5w_A_2061j5w   A     MSESELENOMETHIONINE L - 237
1j5w_A_2061j5w   A     MSESELENOMETHIONINE K - 238
1j5w_A_2061j5w   A     MSESELENOMETHIONINE C - 239
1k4g_A_3281k4g   A     ZNZINC ION H - 349
1k4g_A_3281k4g   A     ZNZINC ION N - 350
1k4g_A_3281k4g   A     ZNZINC ION A - 352
1k4g_A_3281k4g   A     ZNZINC ION F - 353
1k4g_A_3281k4g   A     ZNZINC ION Q - 356
1kho_A_941kho   A     ZNZINC ION Y - 127
1kkt_A_3331kkt   A     CACALCIUM ION F - 333
1kkt_A_3331kkt   A     MANALPHA-D-MANNOSE Q - 348
1kkt_A_3331kkt   A     MANALPHA-D-MANNOSE I - 351
1kkt_A_3331kkt   A     MANALPHA-D-MANNOSE D - 352
1kkt_A_3331kkt   A     MANALPHA-D-MANNOSE L - 355
1kkt_A_3331kkt   A     NAGN-ACETYL-D-GLUCOSAMINE V - 358
1kkt_A_3331kkt   A     NAGN-ACETYL-D-GLUCOSAMINE D - 359
1kkt_A_3331kkt   A     MANALPHA-D-MANNOSE D - 359
1kkt_A_3331kkt   A     NAGN-ACETYL-D-GLUCOSAMINE G - 360
1kkt_A_3331kkt   A     NAGN-ACETYL-D-GLUCOSAMINE E - 362
1kkt_A_3331kkt   A     NAGN-ACETYL-D-GLUCOSAMINE A - 363
1kkt_A_3331kkt   A     NAGN-ACETYL-D-GLUCOSAMINE N - 366
1kkt_A_4091kkt   A     CACALCIUM ION E - 409
1kkt_A_4091kkt   A     CACALCIUM ION E - 412
1kkt_A_4091kkt   A     MANALPHA-D-MANNOSE T - 421
1kkt_A_4091kkt   A     MANALPHA-D-MANNOSE K - 423
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE I - 425
1kkt_A_4091kkt   A     MANALPHA-D-MANNOSE I - 425
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE Y - 426
1kkt_A_4091kkt   A     MANALPHA-D-MANNOSE Y - 426
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE W - 429
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE W - 431
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE N - 432
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE F - 434
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE V - 435
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE N - 438
1kkt_A_4091kkt   A     NAGN-ACETYL-D-GLUCOSAMINE S - 439
1oh0_A_61oh0   A     EQUEQUILENIN Y - 16
1oh0_A_61oh0   A     EQUEQUILENIN I - 17
1oh0_A_61oh0   A     EQUEQUILENIN V - 20
1pb1_A_3541pb1   A     GOLGLYCEROL H - 366
1qsa_A_31qsa   A     ACTACETATE ION Y - 10
1qsa_A_31qsa   A     GOLGLYCEROL Y - 10
1qsa_A_31qsa   A     ACTACETATE ION K - 14
1qsa_A_31qsa   A     GOLGLYCEROL K - 14
1qsa_A_31qsa   A     GOLGLYCEROL W - 17
1qsa_A_31qsa   A     GOLGLYCEROL D - 18
1qsa_A_1541qsa   A     GOLGLYCEROL L - 155
1qsa_A_1541qsa   A     GOLGLYCEROL L - 158
1qsa_A_2851qsa   A     GOLGLYCEROL R - 301
1qsa_A_3191qsa   A     GOLGLYCEROL Y - 323
1qsa_A_3191qsa   A     GOLGLYCEROL W - 324
1qsa_A_3191qsa   A     GOLGLYCEROL D - 327
1qsa_A_3191qsa   A     GOLGLYCEROL E - 331
1qsa_A_3831qsa   A     ACTACETATE ION L - 391
1qsa_A_3831qsa   A     ACTACETATE ION W - 394
1qsa_A_3831qsa   A     ACTACETATE ION L - 396
1qsa_A_3831qsa   A     ACTACETATE ION T - 399
2a0b_*_7072a0b   *     ZNZINC ION H - 728
2a0b_*_7072a0b   *     ZNZINC ION L - 729
2a0b_*_7072a0b   *     ZNZINC ION L - 732
2kfn_A_7092kfn   A     ZNZINC ION I - 709
2kfn_A_7092kfn   A     ZNZINC ION E - 710
2kfn_A_7092kfn   A     MGMAGNESIUM ION L - 711
2kfn_A_7092kfn   A     MGMAGNESIUM ION M - 714
2kfn_A_7092kfn   A     MGMAGNESIUM ION L - 723
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1ah7_*_861ah7   * CATCATALYTIC SITE, SUBSTRATE BINDING.D - 122
1ca1_*_941ca1   * CD33ND ZINC BINDING SITE, CONTAINING CD FROM CRYSTALLISATION BUFFER.H - 126
1ca1_*_941ca1   * ZN1ZINC BINDING SITE AT ACTIVE SITE.D - 130
1hkx_A_3411hkx   A AC1DTT BINDING SITE FOR CHAIN AD - 342
1hkx_A_3411hkx   A AC1DTT BINDING SITE FOR CHAIN AR - 346
1hkx_A_3411hkx   A AC2CL BINDING SITE FOR CHAIN AI - 361
1hkx_A_3411hkx   A AC2CL BINDING SITE FOR CHAIN AY - 369
1oh0_A_61oh0   A AC1EQU BINDING SITE FOR CHAIN AY - 16
2a0b_*_7072a0b   * PHBPHOSPHORYLATION SITE.H - 715
2a0b_*_7072a0b   * ZNBZN BINDING SITE.H - 728

Clusters included in this Subclass
CLUSTER: HH.1.22
CLUSTER: HH.3.1
CLUSTER: HH.4.8