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Information on SUBCLASS 25.1.1
Subclass Accession number: 9265
Subclass: 25.1.1 PSSM
Type: HH alpha-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 4

Average sequence ID (%) : 62.8 +/- 14.1
Average RMSD (Å) : 0.575 +/- 0.150

Consensus geometry
d (Å): 17 delta (°): 90-135 theta (°): 0-45 rho (°): 270-315
Consensus Sequence: hhGLpHppXhXALMXPhYphppXhXLpXD
(φψ)-conformation: aagpbpbapaapaapabpbpbbppbppaa
Pattern: [L][FL]x[V][A][A][H][EQ][F][G][H][AV][LM][G][L][DEQ][H][ST][QST][ADV][AP][EGK][A][L][M]x[P][FIM][Y][RT][FY][RT][EKY][GNP][FLP][PRS][L][HS][KPQ][D][D]x[KNR][G][I][QR][EH][L]
Conservation:0.195-0.392-1.0960.1950.1950.1952.0810.0201.1381.1382.081-0.719-0.1821.1380.195-0.4342.081-0.411-0.957-1.483-0.456-1.1660.1950.1950.666-1.2201.609-0.8001.609-0.7010.534-0.704-1.114-1.114-1.536-1.2690.195-0.630-0.9051.1381.138-1.321-0.6451.1380.195-0.2460.0430.195
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1gkd_A_3951gkd   A395442LFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLHHHHHHHHHHHHTT----S-TTSTTSSS-----S----HHHHHHHHHHaaaaaaaaaaaaagxbxxaxaaxaaxabxbxbbepaxxaaaaaaaaaa
1hv5_A_2131hv5   A213260LLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLHHHHHHHHHHHHTT----S-TTSTT-SS----SS----HHHHHHHHHHaaaaaaaaaaaaagxbxbaxaabaaxabxbpbbwxbxxaaaaaaaaaa
1l6j_A_3951l6j   A395442LFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLHHHHHHHHHHHHTT------TTSTT-SB----SS----HHHHHHHHHHaaaaaaaaaaaaagxbxxaxaaxaaxaxxbxbaxxaxbaaaaaaaaaa
1qib_A_1951qib   A195242LFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELHHHHHHHHHHHHHT----S-TTSTTSSS----SS----HHHHHHHHHHaaaaaaaaaaaaagxbxbaxaaxaaxaxxbxbabxbxxaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID L - 397
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID V - 398
1gkd_A_3951gkd   A     CACALCIUM ION H - 401
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID H - 401
1gkd_A_3951gkd   A     ZNZINC ION H - 401
1gkd_A_3951gkd   A     CACALCIUM ION Q - 402
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID Q - 402
1gkd_A_3951gkd   A     ZNZINC ION Q - 402
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID H - 405
1gkd_A_3951gkd   A     ZNZINC ION H - 405
1gkd_A_3951gkd   A     CACALCIUM ION H - 411
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID H - 411
1gkd_A_3951gkd   A     ZNZINC ION H - 411
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID L - 418
1gkd_A_3951gkd   A     ZNZINC ION M - 419
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID Y - 420
1gkd_A_3951gkd   A     ZNZINC ION Y - 420
1gkd_A_3951gkd   A     CACALCIUM ION P - 421
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID P - 421
1gkd_A_3951gkd   A     BUM2-AMINO-N,3,3-TRIMETHYLBUTANAMIDE P - 421
1gkd_A_3951gkd   A     ZNZINC ION P - 421
1gkd_A_3951gkd   A     CACALCIUM ION M - 422
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID M - 422
1gkd_A_3951gkd   A     BUM2-AMINO-N,3,3-TRIMETHYLBUTANAMIDE M - 422
1gkd_A_3951gkd   A     CACALCIUM ION Y - 423
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID Y - 423
1gkd_A_3951gkd   A     BUM2-AMINO-N,3,3-TRIMETHYLBUTANAMIDE Y - 423
1gkd_A_3951gkd   A     STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID R - 424
1gkd_A_3951gkd   A     BUM2-AMINO-N,3,3-TRIMETHYLBUTANAMIDE R - 424
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID Q - 215
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID V - 216
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID A - 217
1hv5_A_2131hv5   A     ZNZINC ION H - 219
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID H - 219
1hv5_A_2131hv5   A     ZNZINC ION E - 220
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID E - 220
1hv5_A_2131hv5   A     ZNZINC ION H - 223
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE H - 223
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID H - 223
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE V - 224
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE L - 225
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE G - 226
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE L - 227
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE Q - 228
1hv5_A_2131hv5   A     ZNZINC ION H - 229
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE H - 229
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID H - 229
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE T - 230
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID A - 235
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID L - 236
1hv5_A_2131hv5   A     ZNZINC ION M - 237
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE M - 237
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID M - 237
1hv5_A_2131hv5   A     ZNZINC ION S - 238
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID S - 238
1hv5_A_2131hv5   A     ZNZINC ION P - 239
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE P - 239
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID P - 239
1hv5_A_2131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE F - 240
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID F - 240
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID Y - 241
1hv5_A_2131hv5   A     RXP1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID T - 242
1l6j_A_3951l6j   A     ZNZINC ION E - 402
1qib_A_1951qib   A     ZNZINC ION H - 201
1qib_A_1951qib   A     ZNZINC ION E - 202
1qib_A_1951qib   A     ZNZINC ION H - 205
1qib_A_1951qib   A     ZNZINC ION H - 211
1qib_A_1951qib   A     ZNZINC ION M - 219
1qib_A_1951qib   A     ZNZINC ION A - 220
1qib_A_1951qib   A     ZNZINC ION P - 221
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1gkd_A_3951gkd   A ZNAZN BINDING SITE FOR CHAIN AH - 401
1gkd_A_3951gkd   A ZNAZN BINDING SITE FOR CHAIN AH - 405
1gkd_A_3951gkd   A ZNAZN BINDING SITE FOR CHAIN AH - 411
1gkd_A_3951gkd   A BUABUM BINDING SITE FOR CHAIN AP - 421
1gkd_A_3951gkd   A BUABUM BINDING SITE FOR CHAIN AY - 423

Clusters included in this Subclass
CLUSTER: HH.25.0