PDB: 1brm Compound: aspartate-semialdehyde dehydrogenase Classification: OXIDOREDUCTASE Entry date in PDB: 1999-06-22 Resolution [Å]: 2.50 R-Factor: 0.225

CHAIN: A SWISS-PROT/TREMBL: P00353    KEYWORD: 3D-structure    Complete proteome    Diaminopimelate biosynthesis    Lysine biosynthesis    NADP    Oxidoreductase    EC: 1.2.1.11 SCOP: c.2.1.3 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli SCOP: c.2.1.3 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli SCOP: d.81.1.1 Alpha and beta proteins (a+b)    Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain    Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain    GAPDH-like    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli GO:  cytoplasm    cytoplasm    cytoplasm    aspartate-semialdehyde dehydrogenase activity    aspartate-semialdehyde dehydrogenase activity    aspartate-semialdehyde dehydrogenase activity    NAD binding    NAD binding    NAD binding    NADP binding    NADP binding    NADP binding    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    protein dimerization activity    protein dimerization activity    protein dimerization activity    amino acid biosynthesis    amino acid biosynthesis    amino acid biosynthesis    amino acid metabolism    amino acid metabolism    amino acid metabolism    lysine biosynthesis via diaminopimelate    lysine biosynthesis via diaminopimelate    lysine biosynthesis via diaminopimelate    CHAIN: B SWISS-PROT/TREMBL: P00353    KEYWORD: 3D-structure    Complete proteome    Diaminopimelate biosynthesis    Lysine biosynthesis    NADP    Oxidoreductase    EC: 1.2.1.11 SCOP: c.2.1.3 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli SCOP: c.2.1.3 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli SCOP: d.81.1.1 Alpha and beta proteins (a+b)    Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain    Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain    GAPDH-like    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli GO:  cytoplasm    cytoplasm    cytoplasm    aspartate-semialdehyde dehydrogenase activity    aspartate-semialdehyde dehydrogenase activity    aspartate-semialdehyde dehydrogenase activity    NAD binding    NAD binding    NAD binding    NADP binding    NADP binding    NADP binding    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    protein dimerization activity    protein dimerization activity    protein dimerization activity    amino acid biosynthesis    amino acid biosynthesis    amino acid biosynthesis    amino acid metabolism    amino acid metabolism    amino acid metabolism    lysine biosynthesis via diaminopimelate    lysine biosynthesis via diaminopimelate    lysine biosynthesis via diaminopimelate    CHAIN: C SWISS-PROT/TREMBL: P00353    KEYWORD: 3D-structure    Complete proteome    Diaminopimelate biosynthesis    Lysine biosynthesis    NADP    Oxidoreductase    EC: 1.2.1.11 SCOP: c.2.1.3 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli SCOP: c.2.1.3 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli SCOP: d.81.1.1 Alpha and beta proteins (a+b)    Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain    Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain    GAPDH-like    Aspartate beta-semialdehyde dehydrogenase    Escherichia coli GO:  cytoplasm    cytoplasm    cytoplasm    aspartate-semialdehyde dehydrogenase activity    aspartate-semialdehyde dehydrogenase activity    aspartate-semialdehyde dehydrogenase activity    NAD binding    NAD binding    NAD binding    NADP binding    NADP binding    NADP binding    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor    protein dimerization activity    protein dimerization activity    protein dimerization activity    amino acid biosynthesis    amino acid biosynthesis    amino acid biosynthesis    amino acid metabolism    amino acid metabolism    amino acid metabolism    lysine biosynthesis via diaminopimelate    lysine biosynthesis via diaminopimelate    lysine biosynthesis via diaminopimelate

Image Source: PDB

Loops in ArchDB95 clusters

1brm_A_107 - EH => SUBCLASS : 0.1.28
1brm_A_2 - EH => SUBCLASS : 4.7.1
1brm_A_273 - EH => SUBCLASS : 5.10.1
1brm_A_93 - AR => SUBCLASS : 10.11.1
1brm_A_187 - HH => SUBCLASS : 5.3.1
1brm_A_60 - HE => SUBCLASS : 2.2.3
1brm_A_60 - HE => SUBCLASS : 2.2.4
1brm_A_60 - HE => SUBCLASS : 2.2.5
1brm_A_135 - HE => SUBCLASS : 2.4.4
1brm_A_135 - HE => SUBCLASS : 2.4.5
1brm_A_112 - HE => SUBCLASS : 3.1.1
1brm_A_75 - HE => SUBCLASS : 3.1.3
1brm_A_12 - HE => SUBCLASS : 5.7.2

Loops in ArchDB-EC clusters

1brm_A_187 - HH => SUBCLASS : 5.5.3

Loops not clustered in ArchDB

1brm_A_261 - AR
1brm_A_93 - AR
1brm_A_261 - AR
1brm_A_30 - EH
1brm_A_68 - EH
1brm_A_129 - EH
1brm_A_153 - EH
1brm_A_341 - EH
1brm_A_329 - HA
1brm_A_329 - HA
1brm_A_318 - HE
1brm_A_246 - HE
1brm_A_288 - HH
1brm_A_309 - HH
1brm_A_169 - HH
1brm_A_197 - HH

1brm A - percentage of sequence identity: 100
1brm B - percentage of sequence identity: 100
1brm C - percentage of sequence identity: 100
1gl3 A - percentage of sequence identity: 100
1gl3 B - percentage of sequence identity: 100
1mb4 A - percentage of sequence identity: 66
1mb4 B - percentage of sequence identity: 66
1mc4 A - percentage of sequence identity: 66
1nwc A - percentage of sequence identity: 72
1nwc B - percentage of sequence identity: 72
1nwh A - percentage of sequence identity: 72
1nwh B - percentage of sequence identity: 72
1nx6 A - percentage of sequence identity: 72
1oza A - percentage of sequence identity: 71
1pqp A - percentage of sequence identity: 71
1pqu A - percentage of sequence identity: 71
1pqu B - percentage of sequence identity: 71
1pqu C - percentage of sequence identity: 71
1pqu D - percentage of sequence identity: 71
1pr3 A - percentage of sequence identity: 71
1ps8 A - percentage of sequence identity: 71
1pu2 A - percentage of sequence identity: 71
1q2x A - percentage of sequence identity: 71
1q2x B - percentage of sequence identity: 71
1t4b A - percentage of sequence identity: 99
1t4b B - percentage of sequence identity: 99
1t4d A - percentage of sequence identity: 99
1t4d B - percentage of sequence identity: 99
1t4d C - percentage of sequence identity: 99
1ta4 A - percentage of sequence identity: 72
1tb4 A - percentage of sequence identity: 72