PDB: 1ez4 Compound: lactate dehydrogenase Classification: OXIDOREDUCTASE Entry date in PDB: 2001-12-28 Resolution [Å]: 2.30 R-Factor: 0.205

CHAIN: A SWISS-PROT/TREMBL: P56511    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Lactobacillus pentosus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Lactobacillus pentosus GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: B SWISS-PROT/TREMBL: P56511    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Lactobacillus pentosus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Lactobacillus pentosus GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: C SWISS-PROT/TREMBL: P56511    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Lactobacillus pentosus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Lactobacillus pentosus GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: D SWISS-PROT/TREMBL: P56511    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Lactobacillus pentosus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Lactobacillus pentosus GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism

Image Source: PDB

Loops in ArchDB40 clusters

1ez4_A_110 - HE => SUBCLASS : 3.1.1
1ez4_A_164 - HE => SUBCLASS : 6.1.1
1ez4_A_140 - HE => SUBCLASS : 6.4.1
1ez4_A_283 - HA => SUBCLASS : 2.2.15
1ez4_A_268 - HA => SUBCLASS : 4.30.1
1ez4_A_47 - EH => SUBCLASS : 2.1.1
1ez4_A_47 - EH => SUBCLASS : 2.1.2
1ez4_A_158 - EH => SUBCLASS : 2.7.2
1ez4_A_22 - EH => SUBCLASS : 3.32.1
1ez4_A_132 - EH => SUBCLASS : 4.28.1
1ez4_A_297 - EH => SUBCLASS : 6.12.1
1ez4_A_198 - AR => SUBCLASS : 5.2.1
1ez4_A_77 - AR => SUBCLASS : 8.10.1
1ez4_A_211 - HH => SUBCLASS : 3.2.1

Loops in ArchDB95 clusters

1ez4_A_47 - EH => SUBCLASS : 2.1.1
1ez4_A_158 - EH => SUBCLASS : 2.7.2
1ez4_A_22 - EH => SUBCLASS : 3.39.1
1ez4_A_132 - EH => SUBCLASS : 4.17.1
1ez4_A_297 - EH => SUBCLASS : 6.8.1
1ez4_A_198 - AR => SUBCLASS : 3.2.1
1ez4_A_77 - AR => SUBCLASS : 8.26.1
1ez4_A_211 - HH => SUBCLASS : 3.1.4
1ez4_A_211 - HH => SUBCLASS : 3.1.7
1ez4_A_211 - HH => SUBCLASS : 3.2.1
1ez4_A_110 - HE => SUBCLASS : 3.1.1
1ez4_A_249 - HE => SUBCLASS : 3.17.1
1ez4_A_164 - HE => SUBCLASS : 6.1.1
1ez4_A_283 - HA => SUBCLASS : 2.2.22
1ez4_A_268 - HA => SUBCLASS : 4.35.1

Loops in ArchDB-EC clusters

1ez4_A_211 - HH => SUBCLASS : 3.3.1

Loops not clustered in ArchDB

1ez4_A_198 - AR
1ez4_A_185 - AR
1ez4_A_185 - AR
1ez4_A_77 - AR
1ez4_A_91 - EH
1ez4_A_209 - EH
1ez4_A_268 - HA
1ez4_A_205 - HA
1ez4_A_189 - HA
1ez4_A_205 - HA
1ez4_A_189 - HA
1ez4_A_283 - HA
1ez4_A_55 - HE
1ez4_A_30 - HE
1ez4_A_223 - HH

1ez4 A - percentage of sequence identity: 100
1ez4 B - percentage of sequence identity: 100
1ez4 C - percentage of sequence identity: 100
1ez4 D - percentage of sequence identity: 100
1llc - - percentage of sequence identity: 66