PDB: 1ezf Compound: farnesyl-diphosphate farnesyltransferase Classification: TRANSFERASE Entry date in PDB: 2000-10-18 Resolution [Å]: 2.15 R-Factor: 0.213

CHAIN: A SWISS-PROT/TREMBL: P37268    KEYWORD: 3D-structure    Cholesterol biosynthesis    Endoplasmic reticulum    Isoprene biosynthesis    Magnesium    Multifunctional enzyme    NADP    Oxidoreductase    Polymorphism    Transferase    Transmembrane    EC: 2.5.1.21 SCOP: a.128.1.2 All alpha proteins    Terpenoid synthases    Terpenoid synthases    Squalene synthase    Squalene synthase    Human (Homo sapiens) GO:  integral to membrane    farnesyl-diphosphate farnesyltransferase activity    transferase activity    biosynthesis    lipid biosynthesis    CHAIN: B SWISS-PROT/TREMBL: P37268    KEYWORD: 3D-structure    Cholesterol biosynthesis    Endoplasmic reticulum    Isoprene biosynthesis    Magnesium    Multifunctional enzyme    NADP    Oxidoreductase    Polymorphism    Transferase    Transmembrane    EC: 2.5.1.21 SCOP: a.128.1.2 All alpha proteins    Terpenoid synthases    Terpenoid synthases    Squalene synthase    Squalene synthase    Human (Homo sapiens) GO:  integral to membrane    farnesyl-diphosphate farnesyltransferase activity    transferase activity    biosynthesis    lipid biosynthesis    CHAIN: C SWISS-PROT/TREMBL: P37268    KEYWORD: 3D-structure    Cholesterol biosynthesis    Endoplasmic reticulum    Isoprene biosynthesis    Magnesium    Multifunctional enzyme    NADP    Oxidoreductase    Polymorphism    Transferase    Transmembrane    EC: 2.5.1.21 SCOP: a.128.1.2 All alpha proteins    Terpenoid synthases    Terpenoid synthases    Squalene synthase    Squalene synthase    Human (Homo sapiens) GO:  integral to membrane    farnesyl-diphosphate farnesyltransferase activity    transferase activity    biosynthesis    lipid biosynthesis

Image Source: PDB

Loops in ArchDB40 clusters

1ezf_A_195 - HH => SUBCLASS : 1.2.32
1ezf_A_125 - HH => SUBCLASS : 2.1.1
1ezf_A_125 - HH => SUBCLASS : 2.1.4
1ezf_A_270 - HH => SUBCLASS : 3.4.5
1ezf_A_270 - HH => SUBCLASS : 3.6.3
1ezf_A_177 - HH => SUBCLASS : 4.1.3
1ezf_A_177 - HH => SUBCLASS : 4.1.7
1ezf_A_64 - HH => SUBCLASS : 5.4.1
1ezf_A_64 - HH => SUBCLASS : 5.4.2
1ezf_A_137 - HH => SUBCLASS : 5.20.1

Loops in ArchDB95 clusters

1ezf_A_195 - HH => SUBCLASS : 1.1.70
1ezf_A_125 - HH => SUBCLASS : 2.1.1
1ezf_A_270 - HH => SUBCLASS : 3.3.3
1ezf_A_270 - HH => SUBCLASS : 3.5.1
1ezf_A_177 - HH => SUBCLASS : 4.1.4
1ezf_A_64 - HH => SUBCLASS : 5.3.2
1ezf_A_64 - HH => SUBCLASS : 5.3.3
1ezf_A_137 - HH => SUBCLASS : 5.29.1

Loops in ArchDB-EC clusters

1ezf_A_64 - HH => SUBCLASS : 5.5.1

Loops not clustered in ArchDB

1ezf_A_39 - HH
1ezf_A_283 - HH
1ezf_A_252 - HH
1ezf_A_233 - HH
1ezf_A_220 - HH
1ezf_A_201 - HH
1ezf_A_165 - HH
1ezf_A_119 - HH
1ezf_A_90 - HH
1ezf_A_54 - HH
1ezf_A_331 - HH

1ezf A - percentage of sequence identity: 100
1ezf B - percentage of sequence identity: 100
1ezf C - percentage of sequence identity: 100