PDB: 1f42 Compound: interleukin-12 beta chain Classification: CYTOKINE Entry date in PDB: 2001-06-13 Resolution [Å]: 2.50 R-Factor: 0.227

CHAIN: A SWISS-PROT/TREMBL: P29460    KEYWORD: 3D-structure    Cytokine    Glycoprotein    Immunoglobulin domain    Signal    SCOP: b.1.1.4 All beta proteins    Immunoglobulin-like beta-sandwich    Immunoglobulin    I set domains    The p40 domain of interleukin-12 (IL-12 beta chain), N-terminal domain    Human (Homo sapiens) SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3    Human (Homo sapiens) SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3    Human (Homo sapiens) GO:  membrane    hematopoietin/interferon-class (D200-domain) cytokine receptor activity

Image Source: PDB

Loops in ArchDB40 clusters

1f42_A_152 - HA => SUBCLASS : 2.3.2
1f42_A_2 - HA => SUBCLASS : 2.5.1
1f42_A_186 - HA => SUBCLASS : 2.7.1
1f42_A_197 - EH => SUBCLASS : 1.1.1
1f42_A_273 - AR => SUBCLASS : 3.6.3
1f42_A_267 - AR => SUBCLASS : 3.8.1
1f42_A_273 - AR => SUBCLASS : 4.6.3
1f42_A_267 - AR => SUBCLASS : 5.1.1

Loops in ArchDB95 clusters

1f42_A_197 - EH => SUBCLASS : 1.1.1
1f42_A_267 - AR => SUBCLASS : 3.4.4
1f42_A_273 - AR => SUBCLASS : 3.6.3
1f42_A_273 - AR => SUBCLASS : 4.2.8
1f42_A_273 - AR => SUBCLASS : 4.5.1
1f42_A_152 - HA => SUBCLASS : 2.3.5
1f42_A_2 - HA => SUBCLASS : 2.4.1
1f42_A_2 - HA => SUBCLASS : 2.4.2
1f42_A_186 - HA => SUBCLASS : 2.6.1
1f42_A_152 - HA => SUBCLASS : 3.10.1

Loops not clustered in ArchDB

1f42_A_8 - AR
1f42_A_229 - AR
1f42_A_162 - AR
1f42_A_146 - AR
1f42_A_117 - AR
1f42_A_89 - AR
1f42_A_52 - AR
1f42_A_22 - AR
1f42_A_48 - AR
1f42_A_73 - HA
1f42_A_283 - HA
1f42_A_249 - HA
1f42_A_217 - HA
1f42_A_37 - HA
1f42_A_130 - HA
1f42_A_108 - HA
1f42_A_64 - HA
1f42_A_207 - HE

1f45 A - percentage of sequence identity: 100