PDB: 1h2k Compound: factor inhibiting hif1 Classification: TRANSCRIPTION ACTIVATOR/INHIBITOR Entry date in PDB: 2002-11-28 Resolution [Å]: 2.15 R-Factor: 0.180

CHAIN: A SWISS-PROT/TREMBL: Q9NWT6    KEYWORD: 3D-structure    Dioxygenase    Iron    Nuclear protein    Oxidoreductase    Transcription regulation    EC: 1.14.11.16 SCOP: b.82.2.6 All beta proteins    Double-stranded beta-helix    Clavaminate synthase-like    Hypoxia-inducible factor HIF ihhibitor (FIH1)    Hypoxia-inducible factor HIF ihhibitor (FIH1)    Human (Homo sapiens) GO:   CHAIN: S SWISS-PROT/TREMBL: Q16665    KEYWORD: 3D-structure    Acetylation    Activator    Alternative splicing    DNA-binding    Hydroxylation    Nuclear protein    Phosphorylation    Polymorphism    Repeat    S-nitrosylation    Transcription regulation    SCOP: j.96.1.1 Peptides    Transactivation domain    Transactivation domain    Transactivation domain    C-terminal activation domain (CTAD) of HIF-1alpha    Human (Homo sapiens) GO:  nucleus    signal transducer activity    transcription factor activity    transcription regulator activity    regulation of transcription    regulation of transcription, DNA-dependent    signal transduction

Image Source: PDB

Loops in ArchDB40 clusters

1h2k_A_18 - HA => SUBCLASS : 4.11.1
1h2k_A_18 - HA => SUBCLASS : 4.13.1
1h2k_A_118 - EH => SUBCLASS : 1.1.1
1h2k_A_118 - EH => SUBCLASS : 1.1.2
1h2k_A_214 - EH => SUBCLASS : 1.1.16
1h2k_A_44 - EH => SUBCLASS : 3.1.1
1h2k_A_186 - AR => SUBCLASS : 1.2.1
1h2k_A_270 - AR => SUBCLASS : 3.1.1
1h2k_A_260 - AR => SUBCLASS : 3.3.1
1h2k_A_260 - AR => SUBCLASS : 3.3.2
1h2k_A_270 - AR => SUBCLASS : 3.5.1
1h2k_A_312 - HH => SUBCLASS : 2.4.6

Loops in ArchDB95 clusters

1h2k_A_118 - EH => SUBCLASS : 1.1.1
1h2k_A_214 - EH => SUBCLASS : 1.1.12
1h2k_A_214 - EH => SUBCLASS : 1.1.20
1h2k_A_44 - EH => SUBCLASS : 3.2.1
1h2k_A_270 - AR => SUBCLASS : 1.1.1
1h2k_A_203 - AR => SUBCLASS : 1.3.1
1h2k_A_260 - AR => SUBCLASS : 2.3.1
1h2k_A_270 - AR => SUBCLASS : 2.3.1
1h2k_A_260 - AR => SUBCLASS : 2.3.2
1h2k_A_39 - AR => SUBCLASS : 2.9.4
1h2k_A_186 - AR => SUBCLASS : 3.3.3
1h2k_A_312 - HH => SUBCLASS : 2.5.9
1h2k_A_312 - HH => SUBCLASS : 2.5.10
1h2k_A_18 - HA => SUBCLASS : 4.28.1

Loops in ArchDB-EC clusters

1h2k_A_312 - HH => SUBCLASS : 2.6.3

Loops not clustered in ArchDB

1h2k_A_278 - AR
1h2k_A_278 - AR
1h2k_A_24 - AR
1h2k_A_39 - AR
1h2k_A_182 - AR
1h2k_A_186 - AR
1h2k_A_195 - AR
1h2k_A_203 - AR
1h2k_A_260 - AR
1h2k_A_270 - AR
1h2k_A_195 - AR
1h2k_A_182 - AR
1h2k_A_24 - AR
1h2k_A_62 - EH
1h2k_A_143 - EH
1h2k_A_290 - EH
1h2k_A_90 - HA
1h2k_A_90 - HA
1h2k_A_18 - HA
1h2k_A_224 - HE
1h2k_A_125 - HE
1h2k_A_78 - HE
1h2k_A_50 - HE
1h2k_A_167 - HE
1h2k_A_156 - HH

1h2l A - percentage of sequence identity: 100
1h2m A - percentage of sequence identity: 100
1h2n A - percentage of sequence identity: 100
1iz3 A - percentage of sequence identity: 99
1mze A - percentage of sequence identity: 100
1mzf A - percentage of sequence identity: 100
1yci A - percentage of sequence identity: 100
null nu - percentage of sequence identity: 0