PDB: 1i0z Compound: l-lactate dehydrogenase h chain Classification: OXIDOREDUCTASE Entry date in PDB: 2001-03-28 Resolution [Å]: 2.10 R-Factor: 0.179

CHAIN: A SWISS-PROT/TREMBL: P07195    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: B SWISS-PROT/TREMBL: P07195    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism

Image Source: PDB

Loops in ArchDB95 clusters

1i0z_A_47 - EH => SUBCLASS : 2.1.3
1i0z_A_22 - EH => SUBCLASS : 3.5.1
1i0z_A_299 - EH => SUBCLASS : 6.8.2
1i0z_A_91 - EH => SUBCLASS : 11.3.1
1i0z_A_198 - AR => SUBCLASS : 3.2.1
1i0z_A_76 - AR => SUBCLASS : 10.1.1
1i0z_A_228 - HH => SUBCLASS : 4.45.1
1i0z_A_250 - HE => SUBCLASS : 3.17.1
1i0z_A_110 - HE => SUBCLASS : 4.1.1
1i0z_A_110 - HE => SUBCLASS : 4.1.3
1i0z_A_30 - HE => SUBCLASS : 4.2.2
1i0z_A_55 - HE => SUBCLASS : 4.57.1
1i0z_A_164 - HE => SUBCLASS : 6.1.4
1i0z_A_140 - HE => SUBCLASS : 6.2.1
1i0z_A_164 - HE => SUBCLASS : 7.16.1

Loops in ArchDB-EC clusters

1i0z_A_140 - HE => SUBCLASS : 6.1.2

Loops not clustered in ArchDB

1i0z_A_198 - AR
1i0z_A_76 - AR
1i0z_A_132 - EH
1i0z_A_158 - EH
1i0z_A_209 - EH
1i0z_A_269 - HA
1i0z_A_205 - HA
1i0z_A_189 - HA
1i0z_A_288 - HA
1i0z_A_269 - HA
1i0z_A_205 - HA
1i0z_A_189 - HA
1i0z_A_288 - HA
1i0z_A_3 - HE
1i0z_A_211 - HH

1i0z A - percentage of sequence identity: 100
1i0z B - percentage of sequence identity: 100
1i10 A - percentage of sequence identity: 75
1i10 B - percentage of sequence identity: 75
1i10 C - percentage of sequence identity: 75
1i10 D - percentage of sequence identity: 75
1i10 E - percentage of sequence identity: 75
1i10 F - percentage of sequence identity: 75
1i10 G - percentage of sequence identity: 75
1i10 H - percentage of sequence identity: 75
1ldm - - percentage of sequence identity: 72
1t2f A - percentage of sequence identity: 99
1t2f B - percentage of sequence identity: 99
1t2f C - percentage of sequence identity: 99
1t2f D - percentage of sequence identity: 99
1v6a A - percentage of sequence identity: 76
1v6a B - percentage of sequence identity: 76
2ldx - - percentage of sequence identity: 64
5ldh - - percentage of sequence identity: 94
6ldh - - percentage of sequence identity: 72
8ldh - - percentage of sequence identity: 72
9ldb A - percentage of sequence identity: 76
9ldb B - percentage of sequence identity: 76
9ldt A - percentage of sequence identity: 76
9ldt B - percentage of sequence identity: 76