PDB: 1i10 Compound: l-lactate dehydrogenase m chain Classification: OXIDOREDUCTASE Entry date in PDB: 2001-03-28 Resolution [Å]: 2.30 R-Factor: 0.200

CHAIN: A SWISS-PROT/TREMBL: P00338    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    Polymorphism    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: B SWISS-PROT/TREMBL: P00338    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    Polymorphism    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: C SWISS-PROT/TREMBL: P00338    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    Polymorphism    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: D SWISS-PROT/TREMBL: P00338    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    Polymorphism    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: E SWISS-PROT/TREMBL: P00338    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    Polymorphism    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: F SWISS-PROT/TREMBL: P00338    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    Polymorphism    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: G SWISS-PROT/TREMBL: P00338    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    Polymorphism    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: H SWISS-PROT/TREMBL: P00338    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    Polymorphism    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), muscle isoform (M chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism

Image Source: PDB

Loops in ArchDB95 clusters

1i10_A_46 - EH => SUBCLASS : 2.1.3
1i10_A_131 - EH => SUBCLASS : 4.17.1
1i10_A_298 - EH => SUBCLASS : 6.8.2
1i10_A_197 - AR => SUBCLASS : 3.2.1
1i10_A_29 - HE => SUBCLASS : 4.2.2
1i10_A_54 - HE => SUBCLASS : 4.57.1
1i10_A_139 - HE => SUBCLASS : 6.2.1
1i10_A_163 - HE => SUBCLASS : 7.16.1

Loops not clustered in ArchDB

1i10_A_75 - AR
1i10_A_208 - EH
1i10_A_157 - EH
1i10_A_90 - EH
1i10_A_21 - EH
1i10_A_287 - HA
1i10_A_268 - HA
1i10_A_204 - HA
1i10_A_188 - HA
1i10_A_3 - HE
1i10_A_109 - HE
1i10_A_249 - HE
1i10_A_210 - HH
1i10_A_227 - HH

1i0z A - percentage of sequence identity: 75
1i0z B - percentage of sequence identity: 75
1i10 A - percentage of sequence identity: 100
1i10 B - percentage of sequence identity: 100
1i10 C - percentage of sequence identity: 100
1i10 D - percentage of sequence identity: 100
1i10 E - percentage of sequence identity: 100
1i10 F - percentage of sequence identity: 100
1i10 G - percentage of sequence identity: 100
1i10 H - percentage of sequence identity: 100
1ldm - - percentage of sequence identity: 76
1t2f A - percentage of sequence identity: 75
1t2f B - percentage of sequence identity: 75
1t2f C - percentage of sequence identity: 75
1t2f D - percentage of sequence identity: 75
1v6a A - percentage of sequence identity: 75
1v6a B - percentage of sequence identity: 75
2ldx - - percentage of sequence identity: 71
3ldh - - percentage of sequence identity: 62
5ldh - - percentage of sequence identity: 75
6ldh - - percentage of sequence identity: 76
8ldh - - percentage of sequence identity: 76
9ldb A - percentage of sequence identity: 92
9ldb B - percentage of sequence identity: 92
9ldt A - percentage of sequence identity: 92
9ldt B - percentage of sequence identity: 92