PDB: 1ir3 Compound: insulin receptor Classification: COMPLEX (TRANSFERASE/SUBSTRATE) Entry date in PDB: 1998-01-07 Resolution [Å]: 1.90 R-Factor: 0.194

CHAIN: A SWISS-PROT/TREMBL: P06213    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Diabetes mellitus    Disease mutation    Glycoprotein    Phosphorylation    Polymorphism    Receptor    Repeat    Signal    Transferase    Transmembrane    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    Insulin receptor    Human (Homo sapiens) GO:  membrane    ATP binding    epidermal growth factor receptor activity    protein kinase activity    protein-tyrosine kinase activity    transmembrane receptor protein tyrosine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein tyrosine kinase signaling pathway

Image Source: PDB

Loops in ArchDB95 clusters

1ir3_A_1022 - EH => SUBCLASS : 5.1.2
1ir3_A_1073 - EH => SUBCLASS : 6.7.1
1ir3_A_1146 - AR => SUBCLASS : 5.7.1
1ir3_A_1128 - AR => SUBCLASS : 8.5.1
1ir3_A_1256 - HH => SUBCLASS : 2.1.45
1ir3_A_1236 - HH => SUBCLASS : 9.1.2
1ir3_A_1188 - HH => SUBCLASS : 10.1.1
1ir3_A_1215 - HH => SUBCLASS : 11.1.1
1ir3_A_1106 - HE => SUBCLASS : 1.2.1
1ir3_A_1038 - HE => SUBCLASS : 8.2.1
1ir3_A_1138 - HA => SUBCLASS : 3.1.1
1ir3_A_1062 - HA => SUBCLASS : 6.17.1

Loops in ArchDB-EC clusters

1ir3_A_1215 - HH => SUBCLASS : 11.1.1

Loops in ArchDB-KI clusters

1ir3_A_1146 - AR => SUBCLASS : 5.1.1
1ir3_A_1128 - AR => SUBCLASS : 8.1.1
1ir3_A_1073 - EH => SUBCLASS : 6.3.1
1ir3_A_1022 - EH => SUBCLASS : 6.4.1
1ir3_A_1138 - HA => SUBCLASS : 4.1.1
1ir3_A_1106 - HE => SUBCLASS : 1.1.3
1ir3_A_1038 - HE => SUBCLASS : 8.1.1
1ir3_A_1178 - HH => SUBCLASS : 4.2.1
1ir3_A_1236 - HH => SUBCLASS : 9.1.1
1ir3_A_1188 - HH => SUBCLASS : 10.1.1
1ir3_A_1215 - HH => SUBCLASS : 11.1.1

Loops not clustered in ArchDB

1ir3_A_1146 - AR
1ir3_A_1128 - AR
1ir3_A_1155 - EH
1ir3_A_996 - HA
1ir3_A_1009 - HA
1ir3_A_1009 - HA
1ir3_A_1062 - HA
1ir3_A_1138 - HA
1ir3_A_996 - HA
1ir3_A_1178 - HH
1ir3_A_1084 - HH

Loops not clustered in ArchDB-KI

1ir3_A_1155 - EH
1ir3_A_1170 - EH
1ir3_A_996 - HA
1ir3_A_1009 - HA
1ir3_A_1062 - HA
1ir3_A_1256 - HH
1ir3_A_1084 - HH

1gag A - percentage of sequence identity: 100
1i44 A - percentage of sequence identity: 99
1irk - - percentage of sequence identity: 100
1jqh A - percentage of sequence identity: 80
1jqh B - percentage of sequence identity: 80
1jqh C - percentage of sequence identity: 80
1k3a A - percentage of sequence identity: 80
1m7n A - percentage of sequence identity: 80
1m7n B - percentage of sequence identity: 80
1p14 A - percentage of sequence identity: 99
1p4o B - percentage of sequence identity: 79
1rqq A - percentage of sequence identity: 99
1rqq B - percentage of sequence identity: 99
2auh A - percentage of sequence identity: 99
2b4s B - percentage of sequence identity: 99
2b4s D - percentage of sequence identity: 99