PDB: 1irk Compound: Insulin receptor (tyrosine kinase domain) mutant w Classification: TRANSFERASE (PHOSPHOTRANSFERASE) Entry date in PDB: 1995-02-27 Resolution [Å]: 2.10 R-Factor: 0.196

CHAIN: - SWISS-PROT/TREMBL: P06213    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Diabetes mellitus    Disease mutation    Glycoprotein    Phosphorylation    Polymorphism    Receptor    Repeat    Signal    Transferase    Transmembrane    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    Insulin receptor    Human (Homo sapiens) GO:  membrane    ATP binding    epidermal growth factor receptor activity    protein kinase activity    protein-tyrosine kinase activity    transmembrane receptor protein tyrosine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein tyrosine kinase signaling pathway

Image Source: PDB

Loops in ArchDB-KI clusters

1irk_*_1073 - EH => SUBCLASS : 6.3.1
1irk_*_1138 - HA => SUBCLASS : 4.1.1
1irk_*_1038 - HE => SUBCLASS : 8.1.1
1irk_*_1106 - HE => SUBCLASS : 11.1.1
1irk_*_1178 - HH => SUBCLASS : 4.2.1
1irk_*_1188 - HH => SUBCLASS : 10.1.1
1irk_*_1215 - HH => SUBCLASS : 11.1.1

Loops not clustered in ArchDB-KI

1irk_*_1146 - AR
1irk_*_1170 - EH
1irk_*_1022 - EH
1irk_*_1163 - HA
1irk_*_996 - HA
1irk_*_1062 - HA
1irk_*_1009 - HA
1irk_*_1256 - HH
1irk_*_1084 - HH
1irk_*_1236 - HH

1ir3 A - percentage of sequence identity: 100
1p4o A - percentage of sequence identity: 79