PDB: 1k4t Compound: DNA topoisomerase i Classification: ISOMERASE/DNA Entry date in PDB: 2002-12-04 Resolution [Å]: 2.10 R-Factor: 0.229

CHAIN: A SWISS-PROT/TREMBL: P11387    KEYWORD: 3D-structure    Chromosomal translocation    DNA-binding    Isomerase    Polymorphism    Proto-oncogene    Topoisomerase    EC: 5.99.1.2 SCOP: a.2.8.1 All alpha proteins    Long alpha-hairpin    Eukaryotic DNA topoisomerase I, dispensable insert domain    Eukaryotic DNA topoisomerase I, dispensable insert domain    Eukaryotic DNA topoisomerase I, dispensable insert domain    Human (Homo sapiens) SCOP: d.163.1.2 Alpha and beta proteins (a+b)    DNA breaking-rejoining enzymes    DNA breaking-rejoining enzymes    Eukaryotic DNA topoisomerase I, catalytic core    Eukaryotic DNA topoisomerase I, catalytic core    Human (Homo sapiens) SCOP: d.163.1.2 Alpha and beta proteins (a+b)    DNA breaking-rejoining enzymes    DNA breaking-rejoining enzymes    Eukaryotic DNA topoisomerase I, catalytic core    Eukaryotic DNA topoisomerase I, catalytic core    Human (Homo sapiens) SCOP: e.15.1.1 Multi-domain proteins (alpha and beta)    Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment    Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment    Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment    Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment    Human (Homo sapiens) GO:  DNA binding    DNA topoisomerase type I activity    DNA topological change    DNA unwinding

Image Source: PDB

Loops in ArchDB40 clusters

1k4t_A_321 - HE => SUBCLASS : 0.1.22
1k4t_A_340 - HA => SUBCLASS : 2.1.1
1k4t_A_414 - HA => SUBCLASS : 4.1.2
1k4t_A_521 - HA => SUBCLASS : 4.5.1
1k4t_A_414 - HA => SUBCLASS : 6.1.1
1k4t_A_536 - EH => SUBCLASS : 1.1.6
1k4t_A_424 - EH => SUBCLASS : 4.3.1
1k4t_A_403 - AR => SUBCLASS : 7.6.1
1k4t_A_373 - AR => SUBCLASS : 8.14.1
1k4t_A_434 - HH => SUBCLASS : 1.9.2
1k4t_A_272 - HH => SUBCLASS : 2.1.1
1k4t_A_272 - HH => SUBCLASS : 2.1.3
1k4t_A_303 - HH => SUBCLASS : 2.1.37
1k4t_A_454 - HH => SUBCLASS : 3.4.1
1k4t_A_588 - HH => SUBCLASS : 6.3.1

Loops in ArchDB95 clusters

1k4t_A_536 - EH => SUBCLASS : 1.1.6
1k4t_A_245 - EH => SUBCLASS : 3.1.5
1k4t_A_424 - EH => SUBCLASS : 4.1.3
1k4t_A_373 - AR => SUBCLASS : 6.33.1
1k4t_A_403 - AR => SUBCLASS : 7.26.1
1k4t_A_434 - HH => SUBCLASS : 1.5.4
1k4t_A_272 - HH => SUBCLASS : 2.1.1
1k4t_A_303 - HH => SUBCLASS : 2.1.1
1k4t_A_272 - HH => SUBCLASS : 2.3.1
1k4t_A_454 - HH => SUBCLASS : 3.3.1
1k4t_A_588 - HH => SUBCLASS : 6.15.1
1k4t_A_321 - HE => SUBCLASS : 0.1.13
1k4t_A_340 - HA => SUBCLASS : 2.1.1
1k4t_A_521 - HA => SUBCLASS : 3.2.1
1k4t_A_414 - HA => SUBCLASS : 4.1.1

Loops in ArchDB-EC clusters

1k4t_A_588 - HH => SUBCLASS : 6.1.1

Loops not clustered in ArchDB

1k4t_A_346 - AR
1k4t_A_403 - AR
1k4t_A_373 - AR
1k4t_A_346 - AR
1k4t_A_220 - AR
1k4t_A_220 - AR
1k4t_A_300 - EH
1k4t_A_521 - HA
1k4t_A_241 - HA
1k4t_A_512 - HA
1k4t_A_383 - HA
1k4t_A_359 - HA
1k4t_A_359 - HA
1k4t_A_241 - HA
1k4t_A_383 - HA
1k4t_A_414 - HA
1k4t_A_512 - HA
1k4t_A_340 - HA
1k4t_A_470 - HE
1k4t_A_288 - HE
1k4t_A_251 - HH
1k4t_A_545 - HH
1k4t_A_570 - HH
1k4t_A_612 - HH
1k4t_A_746 - HH
1k4t_A_726 - HH
1k4t_A_717 - HH
1k4t_A_678 - HH
1k4t_A_644 - HH

1a35 A - percentage of sequence identity: 99
1a36 A - percentage of sequence identity: 99
1ej9 A - percentage of sequence identity: 99
1k4s A - percentage of sequence identity: 100
1lpq A - percentage of sequence identity: 99
1nh3 A - percentage of sequence identity: 100
1r49 A - percentage of sequence identity: 99
1rr8 C - percentage of sequence identity: 99
1rrj A - percentage of sequence identity: 99
1sc7 A - percentage of sequence identity: 100
1seu A - percentage of sequence identity: 99
1t8i A - percentage of sequence identity: 100
1tl8 A - percentage of sequence identity: 100