PDB: 1k9a Compound: carboxyl-terminal src kinase Classification: TRANSFERASE Entry date in PDB: 2002-03-20 Resolution [Å]: 2.50 R-Factor: 0.246

CHAIN: A SWISS-PROT/TREMBL: P32577    KEYWORD: 3D-structure    ATP-binding    Phosphorylation    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.34.2.1 All beta proteins    SH3-like barrel    SH3-domain    SH3-domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: B SWISS-PROT/TREMBL: P32577    KEYWORD: 3D-structure    ATP-binding    Phosphorylation    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.34.2.1 All beta proteins    SH3-like barrel    SH3-domain    SH3-domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: C SWISS-PROT/TREMBL: P32577    KEYWORD: 3D-structure    ATP-binding    Phosphorylation    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.34.2.1 All beta proteins    SH3-like barrel    SH3-domain    SH3-domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: D SWISS-PROT/TREMBL: P32577    KEYWORD: 3D-structure    ATP-binding    Phosphorylation    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.34.2.1 All beta proteins    SH3-like barrel    SH3-domain    SH3-domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: E SWISS-PROT/TREMBL: P32577    KEYWORD: 3D-structure    ATP-binding    Phosphorylation    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.34.2.1 All beta proteins    SH3-like barrel    SH3-domain    SH3-domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: F SWISS-PROT/TREMBL: P32577    KEYWORD: 3D-structure    ATP-binding    Phosphorylation    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.34.2.1 All beta proteins    SH3-like barrel    SH3-domain    SH3-domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    Carboxyl-terminal src kinase (csk)    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation

Image Source: PDB

Loops in ArchDB40 clusters

1k9a_A_126 - HA => SUBCLASS : 2.1.1
1k9a_A_195 - HA => SUBCLASS : 2.2.5
1k9a_A_320 - HA => SUBCLASS : 3.1.1
1k9a_A_251 - HA => SUBCLASS : 3.1.1
1k9a_A_47 - HA => SUBCLASS : 3.1.1
1k9a_A_116 - HA => SUBCLASS : 3.25.1
1k9a_A_35 - HA => SUBCLASS : 5.6.3
1k9a_A_103 - HA => SUBCLASS : 6.5.1
1k9a_A_262 - EH => SUBCLASS : 6.9.1
1k9a_A_328 - AR => SUBCLASS : 5.8.1
1k9a_A_310 - AR => SUBCLASS : 8.2.1
1k9a_A_413 - HH => SUBCLASS : 9.3.1
1k9a_A_395 - HH => SUBCLASS : 11.1.1

Loops in ArchDB95 clusters

1k9a_A_262 - EH => SUBCLASS : 6.7.1
1k9a_A_328 - AR => SUBCLASS : 5.7.1
1k9a_A_169 - AR => SUBCLASS : 5.14.1
1k9a_A_310 - AR => SUBCLASS : 8.5.1
1k9a_A_413 - HH => SUBCLASS : 9.1.1
1k9a_A_395 - HH => SUBCLASS : 11.1.1
1k9a_A_126 - HA => SUBCLASS : 2.1.1
1k9a_A_195 - HA => SUBCLASS : 2.2.5
1k9a_A_47 - HA => SUBCLASS : 3.1.1
1k9a_A_251 - HA => SUBCLASS : 3.1.1
1k9a_A_116 - HA => SUBCLASS : 3.18.1
1k9a_A_103 - HA => SUBCLASS : 7.1.1

Loops not clustered in ArchDB

1k9a_A_57 - AR
1k9a_A_65 - AR
1k9a_A_337 - EH
1k9a_A_77 - EH
1k9a_A_137 - EH
1k9a_A_177 - EH
1k9a_A_217 - EH
1k9a_A_13 - HA
1k9a_A_207 - HA
1k9a_A_89 - HE
1k9a_A_149 - HE
1k9a_A_179 - HE
1k9a_A_231 - HE
1k9a_A_288 - HE
1k9a_A_274 - HH
1k9a_A_355 - HH
1k9a_A_365 - HH

1byg A - percentage of sequence identity: 97
1csk A - percentage of sequence identity: 100
1csk B - percentage of sequence identity: 100
1csk C - percentage of sequence identity: 100
1csk D - percentage of sequence identity: 100
1jeg A - percentage of sequence identity: 98
1k9a A - percentage of sequence identity: 100
1k9a B - percentage of sequence identity: 100
1k9a C - percentage of sequence identity: 100
1k9a D - percentage of sequence identity: 100
1k9a E - percentage of sequence identity: 100
1k9a F - percentage of sequence identity: 100