PDB: 1me4 Compound: cruzipain Classification: HYDROLASE Entry date in PDB: 2002-12-18 Resolution [Å]: 1.20 R-Factor: 0.096

CHAIN: A SWISS-PROT/TREMBL: P25779    KEYWORD: 3D-structure    Autocatalytic cleavage    Glycoprotein    Hydrolase    Multigene family    Signal    Thiol protease    Zymogen    EC: 3.4.22.51 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cruzain    Trypanosoma cruzi GO:  cysteine-type endopeptidase activity    cysteine-type peptidase activity    proteolysis and peptidolysis

Image Source: PDB

Loops in ArchDB40 clusters

1me4_A_117 - HE => SUBCLASS : 2.9.3
1me4_A_170 - HA => SUBCLASS : 10.1.1
1me4_A_109 - EH => SUBCLASS : 4.13.4
1me4_A_109 - EH => SUBCLASS : 4.17.2
1me4_A_109 - EH => SUBCLASS : 4.58.1
1me4_A_25 - HH => SUBCLASS : 8.10.1

Loops in ArchDB95 clusters

1me4_A_109 - EH => SUBCLASS : 4.15.3
1me4_A_109 - EH => SUBCLASS : 4.34.1
1me4_A_4 - EH => SUBCLASS : 16.1.1
1me4_A_25 - HH => SUBCLASS : 8.25.1
1me4_A_50 - HH => SUBCLASS : 11.3.1
1me4_A_117 - HE => SUBCLASS : 2.8.1
1me4_A_170 - HA => SUBCLASS : 11.1.1

Loops not clustered in ArchDB

1me4_A_102 - AR
1me4_A_130 - AR
1me4_A_148 - AR
1me4_A_186 - AR
1me4_A_79 - HA
1me4_A_159 - HA
1me4_A_68 - HE

1aim - - percentage of sequence identity: 99
1ewl A - percentage of sequence identity: 100
1ewm A - percentage of sequence identity: 100
1ewo A - percentage of sequence identity: 100
1ewp A - percentage of sequence identity: 100
1f29 A - percentage of sequence identity: 100
1f29 B - percentage of sequence identity: 100
1f29 C - percentage of sequence identity: 100
1f2a A - percentage of sequence identity: 100
1f2b A - percentage of sequence identity: 100
1f2c A - percentage of sequence identity: 100
1u9q X - percentage of sequence identity: 100
2aim - - percentage of sequence identity: 100