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Information on 1ols
PDB: 1ols
Compound: 2-oxoisovalerate dehydrogenase alpha subunit
Classification: OXIDOREDUCTASE
Entry date in PDB: 2003-08-15
Resolution [Å]: 1.85
R-Factor: 0.172


CHAIN: A
SWISS-PROT/TREMBL: P12694
   KEYWORD: 3D-structure    Disease mutation    Flavoprotein    Maple syrup urine disease    Mitochondrion    Oxidoreductase    Phosphorylation    Thiamine pyrophosphate    Transit peptide   
EC: 1.2.4.4
SCOP: c.36.1.11 Alpha and beta proteins (a/b)    Thiamin diphosphate-binding fold (THDP-binding)    Thiamin diphosphate-binding fold (THDP-binding)    Branched-chain alpha-keto acid dehydrogenase PP module    Branched-chain alpha-keto acid dehydrogenase, PP module    Human (Homo sapiens)
GO:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor    metabolism   


CHAIN: B
1ols Image
Image Source: PDB

Stored Loops of 1ols

Loops in ArchDB40 clusters

1ols_A_224 - HA => SUBCLASS : 2.3.1
1ols_B_18 - EH => SUBCLASS : 1.1.2
1ols_A_108 - EH => SUBCLASS : 1.1.34
1ols_B_222 - EH => SUBCLASS : 1.2.6
1ols_A_249 - EH => SUBCLASS : 3.1.1
1ols_A_187 - EH => SUBCLASS : 6.3.2
1ols_A_215 - AR => SUBCLASS : 1.2.4
1ols_B_214 - AR => SUBCLASS : 4.15.1
1ols_A_116 - HH => SUBCLASS : 3.2.1
1ols_A_315 - HH => SUBCLASS : 4.1.1
1ols_A_315 - HH => SUBCLASS : 4.1.2

Loops in ArchDB95 clusters

1ols_B_18 - EH => SUBCLASS : 1.1.1
1ols_B_222 - EH => SUBCLASS : 1.3.5
1ols_A_249 - EH => SUBCLASS : 3.2.1
1ols_B_69 - EH => SUBCLASS : 3.8.4
1ols_A_249 - EH => SUBCLASS : 3.9.1
1ols_B_256 - EH => SUBCLASS : 3.26.2
1ols_B_161 - EH => SUBCLASS : 4.5.1
1ols_B_275 - EH => SUBCLASS : 4.43.2
1ols_A_187 - EH => SUBCLASS : 6.3.2
1ols_B_308 - EH => SUBCLASS : 6.49.1
1ols_A_215 - AR => SUBCLASS : 2.8.1
1ols_B_249 - AR => SUBCLASS : 2.11.2
1ols_A_116 - HH => SUBCLASS : 3.1.7
1ols_A_116 - HH => SUBCLASS : 3.2.2
1ols_A_315 - HH => SUBCLASS : 4.1.1
1ols_B_76 - HE => SUBCLASS : 1.1.1
1ols_B_262 - HE => SUBCLASS : 1.2.4
1ols_B_76 - HE => SUBCLASS : 2.1.1
1ols_A_199 - HE => SUBCLASS : 2.1.1
1ols_A_258 - HE => SUBCLASS : 2.1.2
1ols_A_199 - HE => SUBCLASS : 2.1.3
1ols_B_168 - HE => SUBCLASS : 2.2.2
1ols_B_230 - HE => SUBCLASS : 3.2.1
1ols_B_230 - HE => SUBCLASS : 3.2.2
1ols_A_258 - HE => SUBCLASS : 3.5.4
1ols_B_151 - HE => SUBCLASS : 3.7.1
1ols_B_23 - HE => SUBCLASS : 4.1.2
1ols_B_60 - HE => SUBCLASS : 4.10.1
1ols_A_93 - HE => SUBCLASS : 5.1.1
1ols_A_224 - HA => SUBCLASS : 2.3.1

Loops in ArchDB-EC clusters

1ols_A_315 - HH => SUBCLASS : 4.1.1

Loops not clustered in ArchDB

1ols_B_249 - AR
1ols_B_185 - AR
1ols_B_199 - AR
1ols_A_228 - AR
1ols_A_215 - AR
1ols_A_228 - AR
1ols_B_185 - AR
1ols_B_199 - AR
1ols_B_214 - AR
1ols_A_279 - EH
1ols_B_42 - EH
1ols_B_93 - EH
1ols_B_130 - EH
1ols_A_224 - HA
1ols_B_287 - HE
1ols_B_117 - HE
1ols_A_167 - HE
1ols_B_107 - HH
1ols_A_54 - HH
1ols_A_126 - HH
1ols_A_331 - HH
1ols_B_322 - HH

Homologous structures to 1ols classified in ArchDB

1dtw A - percentage of sequence identity: 100
1olu A - percentage of sequence identity: 99
1olx A - percentage of sequence identity: 100
1u5b A - percentage of sequence identity: 100
1v11 A - percentage of sequence identity: 99
1v16 A - percentage of sequence identity: 99
1v1m A - percentage of sequence identity: 99
1v1r A - percentage of sequence identity: 99
1wci A - percentage of sequence identity: 100
1x7w A - percentage of sequence identity: 99
1x7x A - percentage of sequence identity: 99
1x7y A - percentage of sequence identity: 99
1x7z A - percentage of sequence identity: 99
1x80 A - percentage of sequence identity: 100
2beu A - percentage of sequence identity: 100
2bev A - percentage of sequence identity: 100
2bew A - percentage of sequence identity: 100
2bfb A - percentage of sequence identity: 99
2bfc A - percentage of sequence identity: 99
2bfd A - percentage of sequence identity: 99
2bfe A - percentage of sequence identity: 98
2bff A - percentage of sequence identity: 99