PDB: 1pkl Compound: pyruvate kinase Classification: TRANSFERASE Entry date in PDB: 1998-09-23 Resolution [Å]: 2.35 R-Factor: 0.209

CHAIN: A SWISS-PROT/TREMBL: Q27686    KEYWORD: 3D-structure    Allosteric enzyme    Glycolysis    Kinase    Magnesium    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Leishmania mexicana GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: B SWISS-PROT/TREMBL: Q27686    KEYWORD: 3D-structure    Allosteric enzyme    Glycolysis    Kinase    Magnesium    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Leishmania mexicana GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: C SWISS-PROT/TREMBL: Q27686    KEYWORD: 3D-structure    Allosteric enzyme    Glycolysis    Kinase    Magnesium    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Leishmania mexicana GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: D SWISS-PROT/TREMBL: Q27686    KEYWORD: 3D-structure    Allosteric enzyme    Glycolysis    Kinase    Magnesium    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Leishmania mexicana GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: E SWISS-PROT/TREMBL: Q27686    KEYWORD: 3D-structure    Allosteric enzyme    Glycolysis    Kinase    Magnesium    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Leishmania mexicana GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: F SWISS-PROT/TREMBL: Q27686    KEYWORD: 3D-structure    Allosteric enzyme    Glycolysis    Kinase    Magnesium    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Leishmania mexicana GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: G SWISS-PROT/TREMBL: Q27686    KEYWORD: 3D-structure    Allosteric enzyme    Glycolysis    Kinase    Magnesium    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Leishmania mexicana GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: H SWISS-PROT/TREMBL: Q27686    KEYWORD: 3D-structure    Allosteric enzyme    Glycolysis    Kinase    Magnesium    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Leishmania mexicana SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Leishmania mexicana GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis

Image Source: PDB

Loops in ArchDB40 clusters

1pkl_A_140 - HA => SUBCLASS : 4.6.1
1pkl_A_418 - EH => SUBCLASS : 2.1.1
1pkl_A_437 - EH => SUBCLASS : 2.2.1
1pkl_A_123 - EH => SUBCLASS : 2.4.8
1pkl_A_396 - EH => SUBCLASS : 3.13.1
1pkl_A_207 - EH => SUBCLASS : 5.8.1
1pkl_A_22 - EH => SUBCLASS : 7.24.1
1pkl_A_160 - AR => SUBCLASS : 1.1.8
1pkl_A_160 - AR => SUBCLASS : 3.2.8
1pkl_A_98 - AR => SUBCLASS : 4.4.1
1pkl_A_339 - HH => SUBCLASS : 2.1.5
1pkl_A_339 - HH => SUBCLASS : 2.1.42

Loops in ArchDB95 clusters

1pkl_A_257 - EH => SUBCLASS : 0.1.16
1pkl_A_123 - EH => SUBCLASS : 0.1.57
1pkl_A_418 - EH => SUBCLASS : 2.1.1
1pkl_A_396 - EH => SUBCLASS : 3.18.1
1pkl_A_207 - EH => SUBCLASS : 5.13.1
1pkl_A_22 - EH => SUBCLASS : 6.6.1
1pkl_A_160 - AR => SUBCLASS : 1.2.4
1pkl_A_98 - AR => SUBCLASS : 2.3.1
1pkl_A_160 - AR => SUBCLASS : 3.1.1
1pkl_A_262 - HH => SUBCLASS : 2.3.8
1pkl_A_140 - HA => SUBCLASS : 4.6.1

Loops in ArchDB-EC clusters

1pkl_A_262 - HH => SUBCLASS : 2.3.9

Loops not clustered in ArchDB

1pkl_A_79 - AR
1pkl_A_89 - AR
1pkl_A_169 - AR
1pkl_A_79 - AR
1pkl_A_89 - AR
1pkl_A_169 - AR
1pkl_A_160 - AR
1pkl_A_98 - AR
1pkl_A_45 - EH
1pkl_A_234 - EH
1pkl_A_176 - EH
1pkl_A_326 - EH
1pkl_A_292 - EH
1pkl_A_106 - HA
1pkl_A_148 - HA
1pkl_A_140 - HA
1pkl_A_475 - HA
1pkl_A_148 - HA
1pkl_A_106 - HA
1pkl_A_475 - HA
1pkl_A_271 - HE
1pkl_A_191 - HE
1pkl_A_216 - HE
1pkl_A_248 - HE
1pkl_A_57 - HE
1pkl_A_310 - HE
1pkl_A_376 - HE
1pkl_A_404 - HE
1pkl_A_425 - HE
1pkl_A_454 - HE
1pkl_A_34 - HE
1pkl_A_2 - HE
1pkl_A_131 - HE
1pkl_A_331 - HH
1pkl_A_444 - HH
1pkl_A_359 - HH
1pkl_A_242 - HH

1pkl A - percentage of sequence identity: 100
1pkl B - percentage of sequence identity: 100
1pkl C - percentage of sequence identity: 100
1pkl D - percentage of sequence identity: 100
1pkl E - percentage of sequence identity: 100
1pkl F - percentage of sequence identity: 100
1pkl G - percentage of sequence identity: 100
1pkl H - percentage of sequence identity: 100