PDB: 1t2f Compound: l-lactate dehydrogenase b chain Classification: OXIDOREDUCTASE Entry date in PDB: 2004-05-11 Resolution [Å]: 3.00 R-Factor: 0.221

CHAIN: A SWISS-PROT/TREMBL: P07195    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: B SWISS-PROT/TREMBL: P07195    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: C SWISS-PROT/TREMBL: P07195    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: D SWISS-PROT/TREMBL: P07195    KEYWORD: 3D-structure    Disease mutation    Glycolysis    Multigene family    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Human (Homo sapiens), heart isoform (H chain) GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism

Image Source: PDB

1i0z A - percentage of sequence identity: 99
1i10 A - percentage of sequence identity: 75
6ldh - - percentage of sequence identity: 72
9ldt A - percentage of sequence identity: 76