PDB: 7mdh Compound: malate dehydrogenase Classification: CHLOROPLASTIC MALATE DEHYDROGENASE Entry date in PDB: 1999-06-04 Resolution [Å]: 2.40 R-Factor: 0.221

CHAIN: A SWISS-PROT/TREMBL: P17606    KEYWORD: 3D-structure    Chloroplast    Multigene family    NADP    Oxidoreductase    Transit peptide    EC: 1.1.1.82 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Malate dehydrogenase    Sorghum (Sorghum vulgare), chloroplast SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Malate dehydrogenase    Sorghum (Sorghum vulgare), chloroplast GO:  malate dehydrogenase (NADP+) activity    malate dehydrogenase activity    oxidoreductase activity    malate metabolism    tricarboxylic acid cycle intermediate metabolism    CHAIN: B SWISS-PROT/TREMBL: P17606    KEYWORD: 3D-structure    Chloroplast    Multigene family    NADP    Oxidoreductase    Transit peptide    EC: 1.1.1.82 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Malate dehydrogenase    Sorghum (Sorghum vulgare), chloroplast SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Malate dehydrogenase    Sorghum (Sorghum vulgare), chloroplast GO:  malate dehydrogenase (NADP+) activity    malate dehydrogenase activity    oxidoreductase activity    malate metabolism    tricarboxylic acid cycle intermediate metabolism    CHAIN: C SWISS-PROT/TREMBL: P17606    KEYWORD: 3D-structure    Chloroplast    Multigene family    NADP    Oxidoreductase    Transit peptide    EC: 1.1.1.82 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Malate dehydrogenase    Sorghum (Sorghum vulgare), chloroplast SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Malate dehydrogenase    Sorghum (Sorghum vulgare), chloroplast GO:  malate dehydrogenase (NADP+) activity    malate dehydrogenase activity    oxidoreductase activity    malate metabolism    tricarboxylic acid cycle intermediate metabolism    CHAIN: D SWISS-PROT/TREMBL: P17606    KEYWORD: 3D-structure    Chloroplast    Multigene family    NADP    Oxidoreductase    Transit peptide    EC: 1.1.1.82 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Malate dehydrogenase    Sorghum (Sorghum vulgare), chloroplast SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Malate dehydrogenase    Sorghum (Sorghum vulgare), chloroplast GO:  malate dehydrogenase (NADP+) activity    malate dehydrogenase activity    oxidoreductase activity    malate metabolism    tricarboxylic acid cycle intermediate metabolism

Image Source: PDB

Loops in ArchDB40 clusters

7mdh_A_89 - HE => SUBCLASS : 4.9.2
7mdh_A_140 - HE => SUBCLASS : 5.1.2
7mdh_A_140 - HE => SUBCLASS : 5.11.1
7mdh_A_199 - HE => SUBCLASS : 6.1.1
7mdh_A_224 - HA => SUBCLASS : 7.17.1
7mdh_A_78 - EH => SUBCLASS : 1.1.10
7mdh_A_47 - EH => SUBCLASS : 4.14.1
7mdh_A_167 - EH => SUBCLASS : 4.28.1
7mdh_A_125 - EH => SUBCLASS : 11.4.1
7mdh_A_220 - AR => SUBCLASS : 1.2.1
7mdh_A_234 - AR => SUBCLASS : 4.2.4
7mdh_A_234 - AR => SUBCLASS : 4.2.6

Loops in ArchDB95 clusters

7mdh_A_78 - EH => SUBCLASS : 1.1.10
7mdh_A_47 - EH => SUBCLASS : 4.7.1
7mdh_A_167 - EH => SUBCLASS : 4.17.1
7mdh_A_125 - EH => SUBCLASS : 11.8.1
7mdh_A_220 - AR => SUBCLASS : 2.5.3
7mdh_A_234 - AR => SUBCLASS : 3.2.1
7mdh_A_89 - HE => SUBCLASS : 4.7.2
7mdh_A_116 - HE => SUBCLASS : 4.25.1
7mdh_A_140 - HE => SUBCLASS : 5.1.1
7mdh_A_199 - HE => SUBCLASS : 6.1.1
7mdh_A_175 - HE => SUBCLASS : 8.13.1
7mdh_A_57 - HE => SUBCLASS : 9.5.1
7mdh_A_323 - HA => SUBCLASS : 4.9.1
7mdh_A_224 - HA => SUBCLASS : 7.10.1

Loops in ArchDB-EC clusters

7mdh_A_57 - HE => SUBCLASS : 9.4.1

Loops not clustered in ArchDB

7mdh_A_234 - AR
7mdh_A_220 - AR
7mdh_A_107 - EH
7mdh_A_194 - EH
7mdh_A_245 - EH
7mdh_A_337 - EH
7mdh_A_305 - HA
7mdh_A_241 - HA
7mdh_A_224 - HA
7mdh_A_305 - HA
7mdh_A_241 - HA
7mdh_A_323 - HA
7mdh_A_281 - HE
7mdh_A_346 - HH
7mdh_A_268 - HH
7mdh_A_254 - HH

1civ A - percentage of sequence identity: 85
7mdh A - percentage of sequence identity: 100
7mdh B - percentage of sequence identity: 100
7mdh C - percentage of sequence identity: 100
7mdh D - percentage of sequence identity: 100