PDB: 8dfr Compound: Dihydrofolate reductase Classification: OXIDOREDUCTASE(CHNH(D)-NAD+ OR NADP+(A)) Entry date in PDB: 1989-10-15 Resolution [Å]: 1.70 R-Factor: 0.188

CHAIN: - SWISS-PROT/TREMBL: P00378    KEYWORD: 3D-structure    NADP    One-carbon metabolism    Oxidoreductase    EC: 1.5.1.3 SCOP: c.71.1.1 Alpha and beta proteins (a/b)    Dihydrofolate reductases    Dihydrofolate reductases    Dihydrofolate reductases    Dihydrofolate reductases, eukaryotic type    Chicken (Gallus gallus) GO:  dihydrofolate reductase activity    glycine biosynthesis    nucleotide biosynthesis

Image Source: PDB

Loops in ArchDB95 clusters

8dfr_*_88 - EH => SUBCLASS : 2.1.1
8dfr_*_109 - EH => SUBCLASS : 3.40.1
8dfr_*_3 - AR => SUBCLASS : 4.13.4
8dfr_*_130 - AR => SUBCLASS : 7.42.1
8dfr_*_93 - HH => SUBCLASS : 1.1.3
8dfr_*_103 - HE => SUBCLASS : 0.1.42
8dfr_*_103 - HE => SUBCLASS : 0.1.45
8dfr_*_118 - HE => SUBCLASS : 3.7.3
8dfr_*_54 - HE => SUBCLASS : 10.5.1

Loops in ArchDB-EC clusters

8dfr_*_93 - HH => SUBCLASS : 1.1.34

Loops not clustered in ArchDB

8dfr_*_157 - AR
8dfr_*_146 - AR
8dfr_*_146 - AR
8dfr_*_157 - AR
8dfr_*_130 - AR
8dfr_*_3 - AR
8dfr_*_15 - EH
8dfr_*_47 - EH
8dfr_*_70 - HA
8dfr_*_170 - HA
8dfr_*_70 - HA
8dfr_*_170 - HA
8dfr_*_28 - HE

1boz A - percentage of sequence identity: 75
1dhf A - percentage of sequence identity: 75
1dhf B - percentage of sequence identity: 75
1dlr - - percentage of sequence identity: 74
1dls - - percentage of sequence identity: 74
1dr1 - - percentage of sequence identity: 100
1dr2 - - percentage of sequence identity: 100
1dr3 - - percentage of sequence identity: 100
1dr4 - - percentage of sequence identity: 100
1dr5 - - percentage of sequence identity: 100
1dr6 - - percentage of sequence identity: 100
1dr7 - - percentage of sequence identity: 100
1drf - - percentage of sequence identity: 75
1hfp - - percentage of sequence identity: 75
1hfq - - percentage of sequence identity: 75
1hfr - - percentage of sequence identity: 75
1kms A - percentage of sequence identity: 75
1mvs A - percentage of sequence identity: 75
1mvt A - percentage of sequence identity: 75
1ohj - - percentage of sequence identity: 75
1ohk - - percentage of sequence identity: 75
1pd8 A - percentage of sequence identity: 75
1pd9 A - percentage of sequence identity: 75
1pdb A - percentage of sequence identity: 75
1s3u A - percentage of sequence identity: 75
1s3v A - percentage of sequence identity: 75
1s3w A - percentage of sequence identity: 75
1u70 A - percentage of sequence identity: 76
1u71 A - percentage of sequence identity: 74
1u72 A - percentage of sequence identity: 75
1yho A - percentage of sequence identity: 75
2dhf A - percentage of sequence identity: 75
2dhf B - percentage of sequence identity: 75