ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 5.25.1

Subclass Accession number: 1419
Subclass: 5.25.1

Type: EH beta-alpha
DB: ArchDB40

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 1.2 (>50 %)  1.2.1 (>50 %)  1.2.1.3
GO : GO:0004028 (>75 %)  GO:0004872 (>50 %)  GO:0004888 (>50 %)  GO:0004930 (>50 %)  GO:0016620 (>50 %)  GO:0016903 (>50 %)  GO:0030151 (>75 %)  GO:0046914 (>75 %)
SCOP : 53705 (>75 %)  53706 (>75 %)  53707 (>75 %)  53719 (>50 %)  53720 (>50 %)  53721 (>50 %)  53821 (>50 %)  53822 (>50 %)  53823 (>50 %)

Number of loops: 5

Average sequence ID (%) : 29.1 +/- 21.2
Average RMSD (Å) : 0.500 +/- 0.122

Consensus geometry

d (Å): 13

delta (°): 0-45

theta (°): 90-135

rho (°): 45-90

Consensus Sequence:	phAhpXGTD
(φψ)-conformation:	bbpppplaa

Pattern:	[ILM]	[HWY]	[AILV]	[AP]	[FILP]	[EKR]	[NPQS]	[G]	[ST]	[DN]	[AILT]	[AT]	[FLM]	[AFLM]	x	[AGS]	[LMV]	[AFGL]	[HRTW]	[VY]	[ILMV]	[ILV]	[ENR]
Conservation:	0.374	0.972	-0.467	0.058	-1.259	0.261	-0.832	2.898	0.961	1.482	-0.922	0.247	-0.050	-0.804	-1.023	-0.220	0.387	-1.608	-1.038	-0.044	0.162	0.570	-0.105

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1aa6_*_214	1aa6	-	214	236	MHIALKNGSNIALLNAMGHVIIE	EEE---TT-HHHHHHHHHHHHHH	bbxxxxpvaaaaaaaaaaaaaaa
1g8k_A_296	1g8k	A	297	319	LHLAIEPGTDTALFNGLFTYVVE	EEE---TT-HHHHHHHHHHHHHH	bbxxxxpvaaaaaaaaaaaaaaa
1kqf_A_271	1kqf	A	271	293	IYAPIRSGTDITFLSGVLRYLIE	EEE---TT-HHHHHHHHHHHHHH	bbbwbxpvaaaaaaaaaaaaaaa
1q16_A_293	1q16	A	293	315	LWLAPKQGTDAAMALAMGHVMLR	EEE---TT-HHHHHHHHHHHHHH	bbbbxppvaaaaaaaaaaaaaaa
2nap_A_216	2nap	A	216	238	MHVAFRPGTDLAFMHSMAWVIIN	EEE---TTTHHHHHHHHHHHHHH	bbxxxxpvaaaaaaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1aa6_*_214	1aa6	*	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	L - 218
1aa6_*_214	1aa6	*	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	K - 219
1aa6_*_214	1aa6	*	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	N - 220
1aa6_*_214	1aa6	*	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	G - 221
1aa6_*_214	1aa6	*	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	S - 222
1aa6_*_214	1aa6	*	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	N - 223
1g8k_A_296	1g8k	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	I - 301
1g8k_A_296	1g8k	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	E - 302
1g8k_A_296	1g8k	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	P - 303
1g8k_A_296	1g8k	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	G - 304
1g8k_A_296	1g8k	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	T - 305
1g8k_A_296	1g8k	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	D - 306
1kqf_A_271	1kqf	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	I - 275
1kqf_A_271	1kqf	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	R - 276
1kqf_A_271	1kqf	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	S - 277
1kqf_A_271	1kqf	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	G - 278
1kqf_A_271	1kqf	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	T - 279
1kqf_A_271	1kqf	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	D - 280
2nap_A_216	2nap	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	F - 220
2nap_A_216	2nap	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	R - 221
2nap_A_216	2nap	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	P - 222
2nap_A_216	2nap	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	G - 223
2nap_A_216	2nap	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	T - 224
2nap_A_216	2nap	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	D - 225

Clusters included in this Subclass

CLUSTER: EH.5.97