Logo
Information on SUBCLASS 2.2.4
Subclass Accession number: 6049
Subclass: 2.2.4 PSSM
Type: HA beta-beta hairpin
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 45

Average sequence ID (%) : 7.4 +/- 11.8
Average RMSD (Å) : 0.400 +/- 0.210

Consensus geometry
d (Å): 5 delta (°): 90-135 theta (°): 135-180 rho (°): 180-225
Consensus Sequence: XXXpXX
(φψ)-conformation: bbaabb
Pattern: xx[adegnst]xxxxx
Conservation:-0.499-0.4142.3930.133-0.126-0.674-0.271-0.541
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a1v_A_2511a1v   A252259IRTGVRTIEE-SS-EEbbbaabbb
1ava_A_3521ava   A356363EADADLYLEEETTEEEbbbaabbb
1axt_H_881axt   H94101IYFYSFSYEEETTEEEbbbaabbb
1b56_*_511b56   -5663TESTLKTTEE-SS-EEbbbaabbb
1cbk_A_1061cbk   A106113IQNERLTIEESSS-EEbbbaabbb
1ccz_A_1501ccz   A154161AVNRVSQEEEETTEEEbbbaabbb
1d2s_A_751d2s   A8087LHNHWAQLEESSS-EEbbbaabbb
1d7p_M_21961d7p   M21962203FTNMFATWEEETTEEExbbaabbx
1ex2_A_1001ex2   A109116IQAENHSEEEETTEEEbbbaabbb
1ezv_A_911ezv   A95102NISRDFQSEE-SS-EEbxbaabbb
1f94_A_461f94   A4653IDTWNVYNEESSSEEEbbbaabbb
1f9y_A_1061f9y   A106113INTERLTVEE-SS-EEbbbaabbb
1gkp_A_91gkp   A1017IITADSRYEEETTEEExbbaabbb
1gpi_A_2071gpi   A212219EANNDAAAEEETTEEEbbbaabbb
1gpj_A_411gpj   A4552LQTSNRVEEEETTEEEbbbaabbb
1h5w_A_921h5w   A95102AASPVYQKEE-SS-EEpbbaabbb
1is3_A_291is3   A3542GESTDSIAEEETTEEEbabaabba
1iwm_A_301iwm   A3946YISDQQKVEE-SS-EEbbbaabbb
1jni_A_511jni   A5156.VTKNVN..EETTEE..bbaabb.
1jov_A_971jov   A102109YISVHKVREEETTEEEbbbaabbb
1jp4_A_381jp4   A4047KTSATDLQEEETTEEEFabaabbb
1k32_A_1261k32   A127133KSTGRRM.EEETTEE.xbbaabx.
1k55_A_1931k55   A195202EAAPEYLVEEETTEEEbbbaabbb
1luc_A_1431luc   A146153ADNEHIKFEESSS-EEbbbaabbb
1lur_A_11041lur   A11071114RHAPESVSEEETTEEEbbbaabbb
1mbm_A_1001mbm   A105112LLSGEVCLEE-SS-EExbbaabbb
1nbc_A_741nbc   A8390SSTNNADTEEETTEEEbbbaabab
1nc7_A_931nc7   A97104DVGKNHYTEEETTEEEbbbaabbb
1nqk_A_1481nqk   A150157FNGKHIHVEE-SS-EEbbbaaxbb
1oi2_A_3591oi2   A359366VHTPALNWEESSS-EEbbbaabbb
1ori_A_3291ori   A337344FKGQLCELEE-SS-EEbbbaabbb
1pp7_U_1101pp7   U110115.FTRNSV..EETTEE..bbaabb.
1qft_A_1071qft   A114121YSDDNCDVEEETTEEEbbbaabbb
1qwr_A_2371qwr   A243250VQGEYFSVEE-SS-EEbbbaabbb
1r6t_A_841r6t   A8491FVDPWTVQEESSS-EEbbbaabbb
1rhc_A_1461rhc   A148155FKGDYFTLEE-SS-EEbbxaabbb
1svb_*_3631svb   -363369TIENNGG.EEETTEE.bbxaabe.
1uhv_A_3601uhv   A363370YRDEHMLVEEETTEEEbbbaabbb
1uu3_A_821uu3   A8996GEGSFSTVEE-SS-EEbbbaabbb
1ux6_A_10041ux6   A10111018YQSSSRFYEEETTEEExabaabbx
1wej_L_1911wej   L196203ATHKTSTSEEETTEEEbbbaabax
1xaa_*_1451xaa   -145152GMSEAEAWEE-SS-EEebbaabbb
2igd_*_62igd   -1219INGKTLKGEE-SS-EEbbxaabbe
2ncd_A_4462ncd   A446451.GVPESV..EETTEE..ebaabx.
2pva_A_2882pva   A291298FKLYDNSREEETTEEEbbbaabax
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1b56_*_511b56   *     PLMPALMITIC ACID T - 56
1b56_*_511b56   *     PLMPALMITIC ACID S - 58
1b56_*_511b56   *     PLMPALMITIC ACID K - 61
1b56_*_511b56   *     PLMPALMITIC ACID T - 63
1d2s_A_751d2s   A     DHTDIHYDROTESTOSTERONE L - 80
1d2s_A_751d2s   A     DHTDIHYDROTESTOSTERONE H - 81
1d2s_A_751d2s   A     DHTDIHYDROTESTOSTERONE N - 82
1d2s_A_751d2s   A     CACALCIUM ION H - 83
1d2s_A_751d2s   A     DHTDIHYDROTESTOSTERONE H - 83
1d2s_A_751d2s   A     DHTDIHYDROTESTOSTERONE W - 84
1d7p_M_21961d7p   M     GOLGLYCEROL F - 2196
1d7p_M_21961d7p   M     GOLGLYCEROL N - 2198
1d7p_M_21961d7p   M     GOLGLYCEROL F - 2200
1d7p_M_21961d7p   M     GOLGLYCEROL A - 2201
1d7p_M_21961d7p   M     GOLGLYCEROL W - 2203
1ex2_A_1001ex2   A     PO4PHOSPHATE ION Q - 110
1ex2_A_1001ex2   A     PO4PHOSPHATE ION S - 115
1ex2_A_1001ex2   A     PO4PHOSPHATE ION T - 117
1f9y_A_1061f9y   A     APCDIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER E - 109
1f9y_A_1061f9y   A     APCDIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER R - 110
1f9y_A_1061f9y   A     APCDIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER L - 111
1f9y_A_1061f9y   A     ACTACETATE ION T - 112
1f9y_A_1061f9y   A     APCDIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER T - 112
1f9y_A_1061f9y   A     APCDIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER V - 113
1gpj_A_411gpj   A     GMC(2R,3R,4S,5S)-4-AMINO-2-[6-(DIMETHYLAMINO)-9H-PURIN-9-YL]-5-(HYDROXYMETHYL)TETRAHYDRO-3-FURANOL T - 47
1gpj_A_411gpj   A     GLUGLUTAMIC ACID T - 47
1gpj_A_411gpj   A     GMC(2R,3R,4S,5S)-4-AMINO-2-[6-(DIMETHYLAMINO)-9H-PURIN-9-YL]-5-(HYDROXYMETHYL)TETRAHYDRO-3-FURANOL S - 48
1gpj_A_411gpj   A     GLUGLUTAMIC ACID S - 48
1gpj_A_411gpj   A     GMC(2R,3R,4S,5S)-4-AMINO-2-[6-(DIMETHYLAMINO)-9H-PURIN-9-YL]-5-(HYDROXYMETHYL)TETRAHYDRO-3-FURANOL N - 49
1gpj_A_411gpj   A     GLUGLUTAMIC ACID N - 49
1gpj_A_411gpj   A     GLUGLUTAMIC ACID R - 50
1is3_A_291is3   A     LATLACTOSE R - 29
1is3_A_291is3   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID S - 31
1is3_A_291is3   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID N - 33
1is3_A_291is3   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID T - 38
1is3_A_291is3   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID D - 39
1is3_A_291is3   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID I - 41
1is3_A_291is3   A     LATLACTOSE H - 44
1is3_A_291is3   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID H - 44
1is3_A_291is3   A     LATLACTOSE D - 46
1is3_A_291is3   A     LATLACTOSE R - 48
1jni_A_511jni   A     HEMPROTOPORPHYRIN IX CONTAINING FE V - 51
1jni_A_511jni   A     HEMPROTOPORPHYRIN IX CONTAINING FE N - 56
1jp4_A_381jp4   A     PO4PHOSPHATE ION K - 40
1jp4_A_381jp4   A     MGMAGNESIUM ION K - 40
1jp4_A_381jp4   A     AMPADENOSINE MONOPHOSPHATE T - 41
1jp4_A_381jp4   A     AMPADENOSINE MONOPHOSPHATE T - 44
1jp4_A_381jp4   A     PO4PHOSPHATE ION D - 45
1jp4_A_381jp4   A     MGMAGNESIUM ION D - 45
1jp4_A_381jp4   A     AMPADENOSINE MONOPHOSPHATE D - 45
1jp4_A_381jp4   A     PO4PHOSPHATE ION L - 46
1jp4_A_381jp4   A     MGMAGNESIUM ION L - 46
1k55_A_1931k55   A     EDO1,2-ETHANEDIOL E - 195
1k55_A_1931k55   A     EDO1,2-ETHANEDIOL A - 197
1k55_A_1931k55   A     EDO1,2-ETHANEDIOL P - 198
1k55_A_1931k55   A     EDO1,2-ETHANEDIOL E - 199
1k55_A_1931k55   A     EDO1,2-ETHANEDIOL Y - 200
1k55_A_1931k55   A     EDO1,2-ETHANEDIOL L - 201
1k55_A_1931k55   A     EDO1,2-ETHANEDIOL V - 202
1k55_A_1931k55   A     KCXLYSINE NZ-CARBOXYLIC ACID K - 205
1k55_A_1931k55   A     SULSULFATE ANION K - 205
1k55_A_1931k55   A     SULSULFATE ANION T - 206
1k55_A_1931k55   A     SULSULFATE ANION G - 207
1k55_A_1931k55   A     SULSULFATE ANION F - 208
1luc_A_1431luc   A     EDO1,2-ETHANEDIOL I - 151
1luc_A_1431luc   A     EDO1,2-ETHANEDIOL K - 152
1luc_A_1431luc   A     EDO1,2-ETHANEDIOL F - 153
1luc_A_1431luc   A     EDO1,2-ETHANEDIOL P - 154
1luc_A_1431luc   A     EDO1,2-ETHANEDIOL K - 155
1luc_A_1431luc   A     EDO1,2-ETHANEDIOL I - 156
1nc7_A_931nc7   A     MSESELENOMETHIONINE L - 93
1nc7_A_931nc7   A     MSESELENOMETHIONINE S - 94
1nc7_A_931nc7   A     EDO1,2-ETHANEDIOL S - 94
1nc7_A_931nc7   A     MSESELENOMETHIONINE R - 95
1nc7_A_931nc7   A     EDO1,2-ETHANEDIOL R - 95
1nc7_A_931nc7   A     MSESELENOMETHIONINE L - 96
1nc7_A_931nc7   A     EDO1,2-ETHANEDIOL L - 96
1nc7_A_931nc7   A     FMTFORMIC ACID N - 101
1nc7_A_931nc7   A     FMTFORMIC ACID H - 102
1nc7_A_931nc7   A     MGMAGNESIUM ION Y - 103
1nc7_A_931nc7   A     FMTFORMIC ACID Y - 103
1nc7_A_931nc7   A     MSESELENOMETHIONINE T - 104
1nc7_A_931nc7   A     MGMAGNESIUM ION T - 104
1pp7_U_1101pp7   U     ZNZINC ION V - 115
1qft_A_1071qft   A     HSMHISTAMINE F - 108
1qft_A_1071qft   A     HSMHISTAMINE D - 110
1qft_A_1071qft   A     HSMHISTAMINE D - 120
1qft_A_1071qft   A     HSMHISTAMINE I - 122
1qft_A_1071qft   A     HSMHISTAMINE V - 124
1qwr_A_2371qwr   A     MSESELENOMETHIONINE I - 237
1qwr_A_2371qwr   A     MSESELENOMETHIONINE I - 239
1qwr_A_2371qwr   A     MSESELENOMETHIONINE W - 253
1qwr_A_2371qwr   A     MSESELENOMETHIONINE I - 255
1qwr_A_2371qwr   A     MSESELENOMETHIONINE A - 259
1r6t_A_841r6t   A     TYMTRYPTOPHANYL-5'AMP P - 87
1uu3_A_821uu3   A     GOLGLYCEROL F - 82
1uu3_A_821uu3   A     GOLGLYCEROL K - 83
1uu3_A_821uu3   A     GOLGLYCEROL F - 84
1uu3_A_821uu3   A     GOLGLYCEROL G - 85
1uu3_A_821uu3   A     GOLGLYCEROL L - 88
1uu3_A_821uu3   A     LY4(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H] [1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE L - 88
1uu3_A_821uu3   A     GOLGLYCEROL G - 89
1uu3_A_821uu3   A     LY4(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H] [1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE G - 89
1uu3_A_821uu3   A     GOLGLYCEROL E - 90
1uu3_A_821uu3   A     LY4(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H] [1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE E - 90
1uu3_A_821uu3   A     GOLGLYCEROL G - 91
1uu3_A_821uu3   A     LY4(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H] [1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE G - 91
1uu3_A_821uu3   A     LY4(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H] [1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE S - 92
1uu3_A_821uu3   A     GOLGLYCEROL F - 93
1uu3_A_821uu3   A     GOLGLYCEROL S - 94
1uu3_A_821uu3   A     LY4(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H] [1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE S - 94
1uu3_A_821uu3   A     LY4(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H] [1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE T - 95
1uu3_A_821uu3   A     LY4(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H] [1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE V - 96
1ux6_A_10041ux6   A     CACALCIUM ION S - 1013
1ux6_A_10041ux6   A     CACALCIUM ION K - 1023
2ncd_A_4462ncd   A     ADPADENOSINE-5'-DIPHOSPHATE V - 447
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1gpi_A_2071gpi   A CATCATALYTIC RESIDUES, GLU A 207 NUCLEOPHILE, GLU A 212 ACID/BE - 207
1gpi_A_2071gpi   A CATCATALYTIC RESIDUES, GLU A 207 NUCLEOPHILE, GLU A 212 ACID/BD - 209
1gpi_A_2071gpi   A CATCATALYTIC RESIDUES, GLU A 207 NUCLEOPHILE, GLU A 212 ACID/BE - 212
1gpj_A_411gpj   A ACTRECOGNITION AND ACTIVE SITE, HERE OCCUPIED BY THE INHIBITOR GLUTAMYCINT - 47
1gpj_A_411gpj   A ACTRECOGNITION AND ACTIVE SITE, HERE OCCUPIED BY THE INHIBITOR GLUTAMYCINS - 48
1gpj_A_411gpj   A AC2GLU BINDING SITE FOR CHAIN AN - 49
1gpj_A_411gpj   A ACTRECOGNITION AND ACTIVE SITE, HERE OCCUPIED BY THE INHIBITOR GLUTAMYCINR - 50
1gpj_A_411gpj   A ACTRECOGNITION AND ACTIVE SITE, HERE OCCUPIED BY THE INHIBITOR GLUTAMYCINE - 52
1uu3_A_821uu3   A AC1LY4 BINDING SITE FOR CHAIN AL - 88
1uu3_A_821uu3   A AC1LY4 BINDING SITE FOR CHAIN AG - 89

Clusters included in this Subclass
CLUSTER: HA.1.18
CLUSTER: HA.1.59
CLUSTER: HA.3.191
CLUSTER: HA.3.23
CLUSTER: HA.4.38
CLUSTER: HA.5.91