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Information on SUBCLASS 8.12.1
Subclass Accession number: 9186
Subclass: 8.12.1 PSSM
Type: HH alpha-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 3

Average sequence ID (%) : 21.9 +/- 25.5
Average RMSD (Å) : 1.167 +/- 0.473

Consensus geometry
d (Å): 19 delta (°): 135-180 theta (°): 90-135 rho (°): 0-45
Consensus Sequence: XhcXXXXphSpX
(φψ)-conformation: aalbabbbppaa
Pattern: [CW][ILW][AF]x[ACS][ALT]xxxx[EL][CNP]x[LMW]x[EKL][AL][GN][HIL][EKP][EL][FT][EN][FL][S][EQ][AQS][MY][L][FV]x[CWY]
Conservation:2.333-0.3300.032-0.8200.062-0.722-0.390-1.507-0.722-0.711-0.893-1.017-1.3110.160-1.115-1.017-0.1871.155-0.820-0.134-0.7110.1710.8340.5461.9251.540-0.3300.9151.9250.4550.0320.650
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1me3_A_251me3   A2556CWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCHHHHHHHHHHHHHHHHTTS----B-HHHHHHHaaaaaaaaaaaaaaaaavbxxbxbxaaaaaaa
2cb5_A_732cb5   A74105WIFSCLNVMRLPFMKKLNIEEFEFSQSYLFFWHHHHHHHHHHHHHHHHTT-S---B-HHHHHHHaaaaaaaaaaaaaaaaalbabbbxxaaaaaaa
3gcb_*_733gcb   -74105WLFAATNQLRLNVLSELNLKEFELSQAYLFFYHHHHHHHHHHHHHHHHTT-SS--B-HHHHHHHaaaaaaaaaaaaaaaaalbabbbxxaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1me3_A_251me3   A     P10[1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER C - 25
1me3_A_251me3   A     P10[1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER W - 26
3gcb_*_733gcb   *     GOLGLYCEROL Q - 81
3gcb_*_733gcb   *     GOLGLYCEROL L - 82
3gcb_*_733gcb   *     GOLGLYCEROL N - 85
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
3gcb_*_733gcb   * A73NUCLEOPHILIC CYSTEINE MUTATED TO ALANINE.A - 73

Clusters included in this Subclass
CLUSTER: HH.8.34