Information on SUBCLASS 8.12.1 |
Subclass Accession number: 9186
Subclass: 8.12.1 Type: HH alpha-alpha DB: ArchDB-EC Image coordinates: Consensus coordinates: |
Number of loops: 3 Average sequence ID (%) : 21.9 +/- 25.5 Average RMSD (Å) : 1.167 +/- 0.473 Consensus geometry
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Consensus Sequence: | XhcXXXXphSpX |
(φψ)-conformation: | aalbabbbppaa |
Pattern: | [CW] | [ILW] | [AF] | x | [ACS] | [ALT] | x | x | x | x | [EL] | [CNP] | x | [LMW] | x | [EKL] | [AL] | [GN] | [HIL] | [EKP] | [EL] | [FT] | [EN] | [FL] | [S] | [EQ] | [AQS] | [MY] | [L] | [FV] | x | [CWY] |
Conservation: | 2.333 | -0.330 | 0.032 | -0.820 | 0.062 | -0.722 | -0.390 | -1.507 | -0.722 | -0.711 | -0.893 | -1.017 | -1.311 | 0.160 | -1.115 | -1.017 | -0.187 | 1.155 | -0.820 | -0.134 | -0.711 | 0.171 | 0.834 | 0.546 | 1.925 | 1.540 | -0.330 | 0.915 | 1.925 | 0.455 | 0.032 | 0.650 |
Loops included in this Subclass |
Loop | PDB | Chain | Start | End | Sequence | Sec Struct | Ramachandran |
1me3_A_25 | 1me3 | A | 25 | 56 | CWAFSAIGNVECQWFLAGHPLTNLSEQMLVSC | HHHHHHHHHHHHHHHHTTS----B-HHHHHHH | aaaaaaaaaaaaaaaaavbxxbxbxaaaaaaa |
2cb5_A_73 | 2cb5 | A | 74 | 105 | WIFSCLNVMRLPFMKKLNIEEFEFSQSYLFFW | HHHHHHHHHHHHHHHHTT-S---B-HHHHHHH | aaaaaaaaaaaaaaaaalbabbbxxaaaaaaa |
3gcb_*_73 | 3gcb | - | 74 | 105 | WLFAATNQLRLNVLSELNLKEFELSQAYLFFY | HHHHHHHHHHHHHHHHTT-SS--B-HHHHHHH | aaaaaaaaaaaaaaaaalbabbbxxaaaaaaa |
PDB ligands within a cut-off distance of 6 Å in this subclass |
Loop | PDB | Chain | Ligands | Residue |
1me3_A_25 | 1me3 | A | P10[1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER | C - 25 |
1me3_A_25 | 1me3 | A | P10[1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER | W - 26 |
3gcb_*_73 | 3gcb | * | GOLGLYCEROL | Q - 81 |
3gcb_*_73 | 3gcb | * | GOLGLYCEROL | L - 82 |
3gcb_*_73 | 3gcb | * | GOLGLYCEROL | N - 85 |
PDB Site Annotated loops in this subclass |
Loop | PDB | Chain | Site | Residue |
3gcb_*_73 | 3gcb | * | A73NUCLEOPHILIC CYSTEINE MUTATED TO ALANINE. | A - 73 |
Clusters included in this Subclass |
CLUSTER: HH.8.34 |