ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 8.21.1

Subclass Accession number: 5050
Subclass: 8.21.1

Type: HH alpha-alpha
DB: ArchDB95

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 4.1 (>50 %)  4.1.99 (>50 %)
GO : GO:0016829 (>75 %)  GO:0016830 (>75 %)  GO:0050371 (>50 %)
SCOP : 53382 (>75 %)  53383 (>75 %)  53397 (>75 %)

Number of loops: 3

Average sequence ID (%) : 72.0 +/- -27.1
Average RMSD (Å) : 0.300 +/- 0.100

Consensus geometry

d (Å): 11

delta (°): 45-90

theta (°): 90-135

rho (°): 90-135

Consensus Sequence:	hXGDEAYAGSpN
(φψ)-conformation:	aappapablpaa

Pattern:	[D]	[HK]	[Q]	[W]	[A]	[AG]	[M]	[IM]	[IMT]	[G]	[D]	[E]	[A]	[Y]	[A]	[G]	[S]	[ER]	[N]	[FY]	[Y]	[DH]	[L]	[EK]	[DKR]	[KT]	[AV]	[KQ]	[E]	[L]	[F]
Conservation:	0.795	-0.847	0.300	3.274	-0.196	-0.913	0.300	-0.802	-1.518	0.795	0.795	0.300	-0.196	1.291	-0.196	0.795	-0.196	-0.937	0.795	0.166	1.291	-0.664	-0.196	-0.690	-1.408	-1.184	-1.185	-0.668	0.300	-0.196	0.795

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1ax4_A_59	1ax4	A	59	89	DHQWAAMITGDEAYAGSRNYYDLKDKAKELF	HHHHHHHHT----SSS-HHHHHHHHHHHHHH	aaaaaaaaaxxapabvpaaaaaaaaaaaaaa
1c7g_A_58	1c7g	A	58	88	DKQWAGMMIGDEAYAGSENFYHLEKTVKELF	HHHHHHTTS----SSS-HHHHHHHHHHHHHH	aaaaaaaaaxxaxabvxaaaaaaaaaaaaaa
1tpl_A_58	1tpl	A	58	88	DKQWAGMMMGDEAYAGSENFYHLERTVQELF	HHHHHHHTT----SSS-HHHHHHHHHHHHHH	aaaaaaaaaxbaxabvpaaaaaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1ax4_A_59	1ax4	A	LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)	Y - 72
1c7g_A_58	1c7g	A	PLPPYRIDOXAL-5'-PHOSPHATE	Y - 71

PDB Site Annotated loops in this subclass

Loop	PDB	Chain	Site	Residue
1ax4_A_59	1ax4	A	POAPOTASSIUM BINDING SITE.	E - 70
1ax4_A_59	1ax4	A	LPBPYRIDOXAL 5-PHOSPHATE BINDING SITE.	Y - 72

Clusters included in this Subclass

CLUSTER: HH.10.49