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Information on SUBCLASS 1.2.5
Subclass Accession number: 1003
Subclass: 1.2.5 PSSM
Type: EH beta-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 1 (>75 %)  
SCOP : 53473 (>75 %)  53473 (>75 %)  53474 (>75 %)  53474 (>75 %)  
 Number of loops: 14

Average sequence ID (%) : 23.5 +/- 21.7
Average RMSD (Å) : 0.557 +/- 0.128

Consensus geometry
d (Å): 5 delta (°): 45-90 theta (°): 135-180 rho (°): 225-270
Consensus Sequence: GpXph
(φψ)-conformation: bbeaa
Pattern: [AILVY]x[AFILV][GIKLMTV][AG][dehqrst][GS]x[aegq][gilt]xx[ailv]xx[agltv][asv]
Conservation:0.610-0.5200.881-0.5442.709-0.5891.515-0.642-0.144-0.584-0.988-0.8860.238-0.361-1.010-0.3490.663
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a8q_*_881a8q   -88104VTLVAHSMGGGELARYVEEEEEETTHHHHHHHHHxbxbbbeaaaaaaaaaa
1brt_*_921brt   -92108AVLVGFSTGTGEVARYVEEEEEEGGGHHHHHHHHxbxbbbeaaaaaaaaaa
1cvl_*_811cvl   -8197VNLIGHSQGGLTSRYVAEEEEEETTHHHHHHHHHbbbbbbeaaaaaaaaaa
1ei9_A_1091ei9   A109125YNAMGFSQGGQFLRAVAEEEEEETTHHHHHHHHHbxbbbbeaaaaaaaaaa
1fj2_A_1081fj2   A108124IILGGFSQGGALSLYTAEEEEEETHHHHHHHHHHbbbbbbeaaaaaaaaaa
1itz_A_5651itz   A565581LIVMGTGSELEIAAKAAEEEEE-GGGHHHHHHHHbbbbbbeaaaaaaaaaa
1ivy_A_1441ivy   A144160LFLTGESYAGIYIPTLAEEEEEETTHHHHHHHHHbbbbbbeaaaaaaaaaa
1l8a_A_7241l8a   A726742VQLLGSGSILRHVREAAEEEEE-GGGHHHHHHHHbbbbbbeaaaaaaaaaa
1lzl_A_1491lzl   A154170IAVGGQSAGGGLAAGTVEEEEEETHHHHHHHHHHbbbbbbeaaaaaaaaaa
1moq_*_4661moq   -467483ALFLGRGDQYPIALEGAEEEEE-GGGHHHHHHHHbbbbbbeaaaaaaaaaa
1nh9_A_281nh9   A2945VIIKARGKAINKAVDVAEEEEEEGGGHHHHHHHHbbbbbbeaaaaaaaaaa
1qj4_A_741qj4   A7490VILVGESCGGLNIAIAAEEEEEETTHHHHHHHHHbbxbbxeaaaaaaaaaa
1qz3_A_1441qz3   A149165IAVGGDSAGGNLAAVTSEEEEEETHHHHHHHHHHbbbbebeaaaaaaaaaa
1udv_A_331udv   A3450VILKGTGREISKAVDVYEEEEEETTHHHHHHHHHbbxbbbeaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ei9_A_1091ei9   A     NAGN-ACETYL-D-GLUCOSAMINE Q - 126
1ei9_A_1091ei9   A     NAGN-ACETYL-D-GLUCOSAMINE R - 127
1moq_*_4661moq   *     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID R - 472
1moq_*_4661moq   *     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID D - 474
1moq_*_4661moq   *     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID Q - 475
1moq_*_4661moq   *     MPD2-METHYL-2,4-PENTANEDIOL Y - 476
1moq_*_4661moq   *     MPD2-METHYL-2,4-PENTANEDIOL L - 480
1moq_*_4661moq   *     GLPGLUCOSAMINE 6-PHOSPHATE L - 484
1moq_*_4661moq   *     GLPGLUCOSAMINE 6-PHOSPHATE K - 485
1moq_*_4661moq   *     GLPGLUCOSAMINE 6-PHOSPHATE E - 488
1qj4_A_741qj4   A     GOLGLYCEROL E - 79
1qj4_A_741qj4   A     GOLGLYCEROL S - 80
1qj4_A_741qj4   A     GOLGLYCEROL C - 81
1qj4_A_741qj4   A     GOLGLYCEROL G - 82
1qz3_A_1441qz3   A     HDS1-HEXADECANOSULFONIC ACID D - 154
1qz3_A_1441qz3   A     HDS1-HEXADECANOSULFONIC ACID S - 155
1qz3_A_1441qz3   A     HDS1-HEXADECANOSULFONIC ACID A - 156
1qz3_A_1441qz3   A     HDS1-HEXADECANOSULFONIC ACID G - 157
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1a8q_*_881a8q   * NULCATALYTIC TRIAD.S - 94
1brt_*_921brt   * NULCATALYTIC TRIAD.S - 98
1cvl_*_811cvl   * ACTTHE CATALYTIC TRIAD OF THE ACTIVE CENTER CONSISTS OF THE RESIDUES SER 87 - HIS 285 - ASP 263, ALTHOUGH THEY ARE NOT EXPOSED TO THE SOLVENT, BUT A NARROW CHANNEL CONNECTS THEM WITH THE SURFACE.S - 87
1cvl_*_811cvl   * OXYPERFORMED OXYANION, STABILIZED BY THE AMIDE NITROGEN ATOMS OF LEU 17 AND GLN 88, ALREADY PRESENT IN CLOSED CONFORMATION OF THE LIPASE.Q - 88
1fj2_A_1081fj2   A ACAACTIVE SITE IN CHAIN AS - 114
1ivy_A_1441ivy   A CATCATALYTIC TRIAD SERINE CARBOXYPEPTIDASE.S - 150
1qj4_A_741qj4   A CATCATALYTIC TRIADS - 80

Clusters included in this Subclass
CLUSTER: EH.1.62
CLUSTER: EH.2.52
CLUSTER: EH.3.34