Logo
Information on SUBCLASS 3.1.1
Subclass Accession number: 1134
Subclass: 3.1.1 PSSM
Type: EH beta-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
SCOP : 51904 (>75 %)  51905 (>75 %)  
 Number of loops: 72

Average sequence ID (%) : 9.6 +/- 14.0
Average RMSD (Å) : 0.678 +/- 0.264

Consensus geometry
d (Å): 9 delta (°): 45-90 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: XXXXpXX
(φψ)-conformation: bbaapaa
Pattern: xxxxx[cdehknqrst]xxxx
Conservation:0.374-0.1890.265-1.059-0.6212.521-0.118-0.8460.072-0.400
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a8l_*_551a8l   -5968IVDFDTPEGKEEETTSHHHHxbxaaxaaaa
1aa6_*_3551aa6   -355363.QYVKDPANR.EETT-HHHH.bpaaxaaaa
1aiu_*_221aiu   -2736FSATWCGPCKEE-TT-HHHHxbbaaxaaaa
1bed_*_211bed   -2534FFSFYCPHCNEE-TT-HHHHbbbaaxaaaa
1bu8_A_451bu8   A5160KISATEPDTIEE-SSSTHHHxbbaabaaaa
1cs1_A_1181cs1   A121130FVDQGDEQALEE-TT-HHHHxbxaaxaaaa
1ctq_A_771ctq   A8190VFAINNTKSFEEETT-HHHHbbbaabaaaa
1dc1_A_3031dc1   A304313SANLTKTEQVEEETT-HHHHbbxaabaaaa
1e6b_A_101e6b   A1221YSYWRSSCAHEE-TT-HHHHxbbaaxaaaa
1e8c_A_2351e8c   A237246IINADDEVGREEETTSHHHHbbxaaxaaaa
1eej_A_881eej   A93102FTDITCGYCHEE-TT-HHHHxbbaabaaaa
1eem_A_241eem   A2736YSMRFCPFAEEE-TT-HHHHxbbaaxaaaa
1eje_A_581eje   A6271ASAPDHHTAREE-TTSHHHHbbpaapaaaa
1f8r_A_911f8r   A9199.LPEKHRIVR.EETT-HHHH.bxaaxaaaa
1fvk_A_221fvk   A2534FFSFFCPHCYEE-TT-HHHHbbbaaxaaaa
1g5a_A_1871g5a   A187196HTSNEHEWAQEEETTSHHHHbbxaaxaaaa
1gnw_A_31gnw   A615FGHPASIATREE-TT-HHHHbbbaaxaaaa
1gwc_A_71gwc   A1019LGAWPSPFVTEE-TT-HHHHxbbaaxaaaa
1h2k_A_441h2k   A4453RLSQSDPRAEEE-TT-HHHHbbxaaxaaaa
1i0r_A_411i0r   A4554CLNKENDTHNEEETTSHHHHbbxaaxaaaa
1imj_A_1541imj   A157166VYGDQDPMGQEEETT-HHHHbbxaaxaaaa
1jdw_*_3691jdw   -371380MVDANEVPIQEEETT-HHHHxbxaaxaaaa
1jfu_A_621jfu   A6776LWATWCVPCREE-TT-HHHHbbbaaxaaaa
1jlv_A_21jlv   A413YYLPGSAPCREE-TT-HHHHxbbaaxaaaa
1jva_A_5081jva   A510519SVDSRDTSLMEEESS-HHHHbbxaaxaaaa
1k0d_A_1141k0d   A117126FSHRSAPNGFEE-TT-HHHHxbbaabaaaa
1k87_A_3991k87   A402411VIQAYQKRCPEEETTBTTHHxbxaaxaaaa
1kng_A_831kng   A8796VWASWCVPCHEE-TT-HHHHbbbaaxaaaa
1ky3_A_841ky3   A8897VYDVTNASSFEEETT-HHHHbbbaabaaaa
1l1l_A_3221l1l   A325334LGSNDDQDFIEEETT-HHHHbbxaaxaaaa
1l1l_A_5701l1l   A576585RFQDSDPLLPEEETT-THHHxbxaapaaaa
1lst_*_1981lst   -198207GLRKDDTELKEE-TT-HHHHxbxaaxaaaa
1lu4_A_10271lu4   A10311040FWTPWCPFCNEE-TT-HHHHxbbaaxaaaa
1mk4_A_1031mk4   A107116VTSPVNKVSIEE-TT-HHHHbbxaaxaaaa
1np6_A_1521np6   A153162LLDINDVEGLEEETT-HHHHbbxaabaaaa
1nwc_A_561nwc   A5664.KSAFDIEEL.EETT-HHHH.xxaaxaaaa
1o8x_A_301o8x   A3544FSASWCPPAREE-TT-HHHHxbbaaxaaaa
1ols_A_2491ols   A252261RVDGNDVFAVEEETT-HHHHbbxaabaaaa
1opd_*_401opd   -4150SASAKDLFKLEEETT-HHHHbbxaabaaaa
1oyj_A_71oyj   A1019LDFWVSPFGQEE-TT-HHHHxbbaaxaaaa
1p0h_A_2781p0h   A282291YVESDNVAAVEEETT-HHHHbbxaaxaaaa
1pda_*_2011pda   -204213ECRLDDSRTREEETT-HHHHbbxaaxaaaa
1ptf_*_401ptf   -4150SVNLKSIMGVEEETT-HHHHbbxaabaaaa
1q5y_A_511q5y   A5968VYEHEKRDLAEEETT-HHHHbbxaaxaaaa
1qgv_A_251qgv   A3039FGHDWDPTCMEE-TTSHHHHbexaaxaaaa
1qlt_A_4651qlt   A472481VFNKKDLIQKEEETT-HHHHbbxaabaaaa
1qs0_A_2701qs0   A273282RVDGNDFVAVEEETT-HHHHbbxaabaaaa
1r26_A_211r26   A2534FTAVWCGPCKEE-TT-HHHHxbbaabaaaa
1r2q_A_951r2q   A99108VYDITNEESFEEETT-HHHHbbbaabaaaa
1r4w_A_61r4w   A1120FYDVLSPYSWEE-TT-HHHHxbbaaxaaaa
1r5a_A_31r5a   A615YYLPASPPCREE-TT-HHHHxbbaapaaaa
1riq_A_1251riq   A128137SVYKDDEEAYEEETT-HHHHbbxaaxaaaa
1rxx_A_3681rxx   A370379VGYDRNTYTNEEETT-HHHHbbbaaxaaaa
1s68_A_91s68   A917.ENHYNSKFI.EETT-HHHH.xxaaxaaaa
1s9r_A_3601s9r   A362371IGYSRNEKTNEEETT-HHHHbbxaaxaaaa
1sqh_A_2721sqh   A272280.IVATNWRSE.EETT-HHHH.bxaaxaaaa
1st0_A_3171st0   A320329ALRADDPLLKEEETT-HHHHbbxaapaaaa
1st9_A_631st9   A6877FWGTWCEPCKEE-TT-HHHHxbbaaxaaaa
1uc7_A_311uc7   A3544LYADWCVACKEE-TT-HHHHbbbaaxaaaa
1uiu_A_3411uiu   A345354SFIGTDALSKEEETT-HHHHbbxaaxaaaa
1umd_A_2321umd   A234243LVDGMDVLASEEETT-HHHHbbxaabaaaa
1uqt_A_3981uqt   A399408IVNPYDRDEVEE-TT-HHHHxbbaabaaaa
1usc_A_491usc   A5362SISPKRFTHGEE-TTSHHHHbbxaaxaaaa
1uuf_A_2211uuf   A222231VVNSRNADEMEEETT-HHHHbbxaabaaaa
1uuq_A_4111uuq   A411419.VFDTDTSTI.EETT-HHHH.xxaaxaaaa
1v2a_A_21v2a   A413YYSLISPPCQEE-TT-HHHHxbbaaxaaaa
1vhc_A_431vhc   A4554EITFRSEAAAEEETTSTTHHbxxaabaaaa
1vhs_A_1191vhs   A119128FIFGHNKPSLEEETT-HHHHbbpaaxaaaa
1vi2_A_1781vi2   A181190VTDLADQQAFEEETT-HHHHbbxaaxaaaa
1ycq_A_861ycq   A8695EFSVKEPRRLEEETT-HHHHbbbaabaaaa
2nap_A_3672nap   A367375.RAIPNAKHR.EETT-HHHH.bbaaxaaaa
2trx_A_222trx   A2736FWAEWCGPCKEE-TT-HHHHxbbaaxaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1e8c_A_2351e8c   A     MSESELENOMETHIONINE N - 239
1e8c_A_2351e8c   A     MSESELENOMETHIONINE D - 241
1e8c_A_2351e8c   A     KCXLYSINE NZ-CARBOXYLIC ACID W - 248
1eem_A_241eem   A     GSHGLUTHATHIONE M - 29
1eem_A_241eem   A     GSHGLUTHATHIONE F - 31
1eem_A_241eem   A     GSHGLUTHATHIONE C - 32
1eem_A_241eem   A     GSHGLUTHATHIONE P - 33
1eem_A_241eem   A     GSHGLUTHATHIONE F - 34
1eem_A_241eem   A     GSHGLUTHATHIONE A - 35
1eem_A_241eem   A     GSHGLUTHATHIONE R - 37
1eje_A_581eje   A     FMNFLAVIN MONONUCLEOTIDE A - 62
1eje_A_581eje   A     FMNFLAVIN MONONUCLEOTIDE S - 63
1eje_A_581eje   A     FMNFLAVIN MONONUCLEOTIDE A - 64
1eje_A_581eje   A     FMNFLAVIN MONONUCLEOTIDE D - 66
1eje_A_581eje   A     FMNFLAVIN MONONUCLEOTIDE H - 67
1eje_A_581eje   A     NINICKEL (II) ION H - 68
1eje_A_581eje   A     FMNFLAVIN MONONUCLEOTIDE H - 68
1eje_A_581eje   A     NINICKEL (II) ION T - 69
1eje_A_581eje   A     FMNFLAVIN MONONUCLEOTIDE T - 69
1eje_A_581eje   A     FMNFLAVIN MONONUCLEOTIDE A - 70
1eje_A_581eje   A     NINICKEL (II) ION S - 75
1eje_A_581eje   A     NINICKEL (II) ION T - 76
1f8r_A_911f8r   A     FADFLAVIN-ADENINE DINUCLEOTIDE L - 91
1f8r_A_911f8r   A     FADFLAVIN-ADENINE DINUCLEOTIDE P - 92
1f8r_A_911f8r   A     FADFLAVIN-ADENINE DINUCLEOTIDE H - 95
1g5a_A_1871g5a   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL H - 187
1gnw_A_31gnw   A     GTXS-HEXYLGLUTATHIONE H - 8
1gnw_A_31gnw   A     GTXS-HEXYLGLUTATHIONE A - 10
1gnw_A_31gnw   A     GTXS-HEXYLGLUTATHIONE S - 11
1gnw_A_31gnw   A     GTXS-HEXYLGLUTATHIONE I - 12
1gnw_A_31gnw   A     GTXS-HEXYLGLUTATHIONE A - 13
1gnw_A_31gnw   A     GTXS-HEXYLGLUTATHIONE T - 14
1gnw_A_31gnw   A     GTXS-HEXYLGLUTATHIONE R - 16
1gwc_A_71gwc   A     GTXS-HEXYLGLUTATHIONE A - 12
1gwc_A_71gwc   A     GTXS-HEXYLGLUTATHIONE P - 14
1gwc_A_71gwc   A     GTXS-HEXYLGLUTATHIONE S - 15
1gwc_A_71gwc   A     GTXS-HEXYLGLUTATHIONE P - 16
1gwc_A_71gwc   A     GTXS-HEXYLGLUTATHIONE F - 17
1gwc_A_71gwc   A     GTXS-HEXYLGLUTATHIONE R - 20
1i0r_A_411i0r   A     FMNFLAVIN MONONUCLEOTIDE C - 45
1i0r_A_411i0r   A     FMNFLAVIN MONONUCLEOTIDE L - 46
1i0r_A_411i0r   A     FMNFLAVIN MONONUCLEOTIDE N - 47
1i0r_A_411i0r   A     FMNFLAVIN MONONUCLEOTIDE E - 49
1i0r_A_411i0r   A     FMNFLAVIN MONONUCLEOTIDE N - 50
1i0r_A_411i0r   A     FMNFLAVIN MONONUCLEOTIDE D - 51
1i0r_A_411i0r   A     FMNFLAVIN MONONUCLEOTIDE T - 52
1i0r_A_411i0r   A     FMNFLAVIN MONONUCLEOTIDE H - 53
1jlv_A_21jlv   A     GSHGLUTHATHIONE S - 9
1jlv_A_21jlv   A     GSHGLUTHATHIONE A - 10
1jlv_A_21jlv   A     GSHGLUTHATHIONE P - 11
1k0d_A_1141k0d   A     GTTGLUTATHIONE H - 119
1k0d_A_1141k0d   A     GTTGLUTATHIONE S - 121
1k0d_A_1141k0d   A     GTTGLUTATHIONE A - 122
1k0d_A_1141k0d   A     GTTGLUTATHIONE P - 123
1k0d_A_1141k0d   A     GTTGLUTATHIONE N - 124
1k0d_A_1141k0d   A     GTTGLUTATHIONE G - 125
1k0d_A_1141k0d   A     GTTGLUTATHIONE K - 127
1k87_A_3991k87   A     FADFLAVIN-ADENINE DINUCLEOTIDE V - 402
1k87_A_3991k87   A     FADFLAVIN-ADENINE DINUCLEOTIDE Q - 404
1k87_A_3991k87   A     FADFLAVIN-ADENINE DINUCLEOTIDE Y - 406
1oyj_A_71oyj   A     GTTGLUTATHIONE F - 12
1oyj_A_71oyj   A     GTTGLUTATHIONE S - 15
1oyj_A_71oyj   A     GTTGLUTATHIONE P - 16
1oyj_A_71oyj   A     GTTGLUTATHIONE F - 17
1oyj_A_71oyj   A     GTTGLUTATHIONE G - 18
1oyj_A_71oyj   A     GTTGLUTATHIONE R - 20
1p0h_A_2781p0h   A     COACOENZYME A Y - 282
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A Y - 282
1p0h_A_2781p0h   A     COACOENZYME A V - 283
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A V - 283
1p0h_A_2781p0h   A     COACOENZYME A E - 284
1p0h_A_2781p0h   A     COACOENZYME A N - 287
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A N - 287
1p0h_A_2781p0h   A     COACOENZYME A V - 288
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A V - 288
1p0h_A_2781p0h   A     COACOENZYME A A - 289
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A A - 289
1p0h_A_2781p0h   A     COACOENZYME A A - 290
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A A - 290
1p0h_A_2781p0h   A     COACOENZYME A R - 292
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A R - 292
1p0h_A_2781p0h   A     COACOENZYME A T - 293
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A T - 293
1p0h_A_2781p0h   A     COACOENZYME A Y - 294
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A Y - 294
1p0h_A_2781p0h   A     COACOENZYME A S - 296
1p0h_A_2781p0h   A     ACOACETYL COENZYME *A S - 296
1q5y_A_511q5y   A     NINICKEL (II) ION Y - 60
1q5y_A_511q5y   A     NINICKEL (II) ION H - 62
1q5y_A_511q5y   A     EGLETHYLENE GLYCOL R - 65
1q5y_A_511q5y   A     NINICKEL (II) ION V - 72
1q5y_A_511q5y   A     NINICKEL (II) ION H - 76
1qlt_A_4651qlt   A     ACTACETATE ION I - 468
1qs0_A_2701qs0   A     MSESELENOMETHIONINE F - 279
1r2q_A_951r2q   A     GOLGLYCEROL D - 101
1r2q_A_951r2q   A     GOLGLYCEROL I - 102
1r2q_A_951r2q   A     GOLGLYCEROL T - 103
1r2q_A_951r2q   A     GOLGLYCEROL N - 104
1r2q_A_951r2q   A     GOLGLYCEROL E - 105
1r2q_A_951r2q   A     GOLGLYCEROL E - 106
1r2q_A_951r2q   A     GOLGLYCEROL S - 107
1r2q_A_951r2q   A     GOLGLYCEROL A - 109
1r2q_A_951r2q   A     GOLGLYCEROL R - 110
1r2q_A_951r2q   A     GOLGLYCEROL N - 113
1r2q_A_951r2q   A     GOLGLYCEROL V - 115
1r2q_A_951r2q   A     GOLGLYCEROL Q - 119
1r2q_A_951r2q   A     GOLGLYCEROL R - 120
1r2q_A_951r2q   A     GOLGLYCEROL Q - 121
1r4w_A_61r4w   A     GSHGLUTHATHIONE L - 15
1r4w_A_61r4w   A     GSHGLUTHATHIONE S - 16
1r4w_A_61r4w   A     GSHGLUTHATHIONE P - 17
1r4w_A_61r4w   A     GSHGLUTHATHIONE Y - 18
1r4w_A_61r4w   A     GSHGLUTHATHIONE S - 19
1r4w_A_61r4w   A     GSHGLUTHATHIONE L - 21
1r5a_A_31r5a   A     CUCOPPER (II) ION T - 3
1r5a_A_31r5a   A     GTSGLUTATHIONE SULFONIC ACID L - 8
1r5a_A_31r5a   A     GTSGLUTATHIONE SULFONIC ACID A - 10
1r5a_A_31r5a   A     GTSGLUTATHIONE SULFONIC ACID S - 11
1r5a_A_31r5a   A     GTSGLUTATHIONE SULFONIC ACID P - 12
1r5a_A_31r5a   A     GTSGLUTATHIONE SULFONIC ACID P - 13
1r5a_A_31r5a   A     GTSGLUTATHIONE SULFONIC ACID C - 14
1rxx_A_3681rxx   A     MSESELENOMETHIONINE V - 370
1rxx_A_3681rxx   A     MSESELENOMETHIONINE Y - 372
1s9r_A_3601s9r   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL R - 366
1s9r_A_3601s9r   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL N - 367
1s9r_A_3601s9r   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL E - 368
1sqh_A_2721sqh   A     MSESELENOMETHIONINE I - 272
1sqh_A_2721sqh   A     MSESELENOMETHIONINE E - 280
1sqh_A_2721sqh   A     MSESELENOMETHIONINE L - 283
1sqh_A_2721sqh   A     MSESELENOMETHIONINE K - 284
1usc_A_491usc   A     FMNFLAVIN MONONUCLEOTIDE S - 53
1usc_A_491usc   A     ACTACETATE ION S - 53
1usc_A_491usc   A     FMNFLAVIN MONONUCLEOTIDE I - 54
1usc_A_491usc   A     FMNFLAVIN MONONUCLEOTIDE S - 55
1usc_A_491usc   A     ACTACETATE ION S - 55
1usc_A_491usc   A     FMNFLAVIN MONONUCLEOTIDE K - 57
1usc_A_491usc   A     FMNFLAVIN MONONUCLEOTIDE R - 58
1usc_A_491usc   A     ACTACETATE ION R - 58
1usc_A_491usc   A     FMNFLAVIN MONONUCLEOTIDE F - 59
1usc_A_491usc   A     FMNFLAVIN MONONUCLEOTIDE T - 60
1usc_A_491usc   A     FMNFLAVIN MONONUCLEOTIDE H - 61
1v2a_A_21v2a   A     GTSGLUTATHIONE SULFONIC ACID S - 6
1v2a_A_21v2a   A     GTSGLUTATHIONE SULFONIC ACID I - 8
1v2a_A_21v2a   A     GTSGLUTATHIONE SULFONIC ACID S - 9
1v2a_A_21v2a   A     GTSGLUTATHIONE SULFONIC ACID P - 10
1v2a_A_21v2a   A     GTSGLUTATHIONE SULFONIC ACID P - 11
1v2a_A_21v2a   A     GTSGLUTATHIONE SULFONIC ACID C - 12
1vhs_A_1191vhs   A     MSESELENOMETHIONINE F - 119
1vhs_A_1191vhs   A     MSESELENOMETHIONINE I - 120
1vhs_A_1191vhs   A     MSESELENOMETHIONINE F - 121
1vhs_A_1191vhs   A     MSESELENOMETHIONINE H - 123
1vhs_A_1191vhs   A     MSESELENOMETHIONINE N - 124
1vhs_A_1191vhs   A     MSESELENOMETHIONINE K - 125
1vhs_A_1191vhs   A     MSESELENOMETHIONINE P - 126
1vi2_A_1781vi2   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE L - 184
2trx_A_222trx   A     MPD2-METHYL-2,4-PENTANEDIOL W - 31
2trx_A_222trx   A     MPD2-METHYL-2,4-PENTANEDIOL P - 34
2trx_A_222trx   A     MPD2-METHYL-2,4-PENTANEDIOL M - 37
2trx_A_222trx   A     MPD2-METHYL-2,4-PENTANEDIOL I - 38
2trx_A_222trx   A     MPD2-METHYL-2,4-PENTANEDIOL I - 41
2trx_A_222trx   A     CUCOPPER (II) ION D - 43
2trx_A_222trx   A     CUCOPPER (II) ION D - 47
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1fvk_A_221fvk   A CAATHE ACTIVE SITE.C - 30
1fvk_A_221fvk   A CAATHE ACTIVE SITE.P - 31
1fvk_A_221fvk   A CAATHE ACTIVE SITE.H - 32
1fvk_A_221fvk   A CAATHE ACTIVE SITE.C - 33
1gwc_A_71gwc   A AC1GTX BINDING SITE FOR CHAIN AS - 15
1gwc_A_71gwc   A AC1GTX BINDING SITE FOR CHAIN AF - 17
1opd_*_401opd   * AS6IN GRAM-POSITIVE HPR HPRS PHOSPHOTRANSFER ABILITY CAN BE INHIBITED THROUGH PHOSPHORYLATION OF SER 46. WHILE SER 46 IS PRESENT IN GRAM-NEGATIVE HPRS THIS TYPE OF REGULATION IS NOT OF PHYSIOLOGICAL IMPORTANCE AS THE BACTERIA LACKS THE NECESSARY KINASE. IT IS POSSIBLE HOWEVER TO MIMIC THE REGULATORY PHOSPHORYLATION THROUGH THE MUTANT SER46ASP.D - 46
1usc_A_491usc   A AC1FMN BINDING SITE FOR CHAIN AS - 53
1usc_A_491usc   A AC1FMN BINDING SITE FOR CHAIN AI - 54
1usc_A_491usc   A AC1FMN BINDING SITE FOR CHAIN AR - 58
1usc_A_491usc   A AC1FMN BINDING SITE FOR CHAIN AF - 59
1usc_A_491usc   A AC1FMN BINDING SITE FOR CHAIN AT - 60

Clusters included in this Subclass
CLUSTER: EH.2.27
CLUSTER: EH.2.85
CLUSTER: EH.3.242
CLUSTER: EH.3.42
CLUSTER: EH.3.59
CLUSTER: EH.3.71
CLUSTER: EH.3.8
CLUSTER: EH.4.15
CLUSTER: EH.4.20
CLUSTER: EH.4.3
CLUSTER: EH.4.99
CLUSTER: EH.5.121
CLUSTER: EH.5.7