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Information on SUBCLASS 3.7.4
Subclass Accession number: 1181
Subclass: 3.7.4 PSSM
Type: EH beta-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 4.1 (>75 %)  4.1.3 (>75 %)  4.1.3.16
GO : GO:0004518 (>75 %)  GO:0004519 (>75 %)  GO:0004540 (>75 %)  GO:0008675 (>75 %)  GO:0008700 (>75 %)  GO:0016788 (>75 %)  GO:0016829 (>75 %)  GO:0016830 (>75 %)  GO:0016832 (>75 %)  GO:0016833 (>75 %)  
SCOP : 51569 (>75 %)  51570 (>75 %)  
 Number of loops: 4

Average sequence ID (%) : 11.1 +/- 15.5
Average RMSD (Å) : 0.800 +/- 0.216

Consensus geometry
d (Å): 13 delta (°): 45-90 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: XXhXXhX
(φψ)-conformation: bbpabaa
Pattern: [AIV][CLP][ATV]x[ANPV][ILV]xx[AFLP][ADEK]x[ACI][GLPV]xx[AIK][DEKY][AKT][ALW]x[AEGK]
Conservation:1.657-0.1710.8811.034-1.2462.538-0.303-0.414-1.4310.140-0.5070.776-1.8000.238-0.230-0.502-0.1370.473-0.220-0.362-0.414
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1fq0_A_171fq0   A1838VPVIVVKKLEHAVPMAKALVAEEEE---SGGGHHHHHHHHHHbxxxbxabaaaaaaaaaaaaa
1gca_*_621gca   -6282ALAINLVDPAAAGTVIEKARGEEEE--SSGGGHHHHHHHHHHbbbbbxabaaaaaaaaaaaaa
1q92_A_1241q92   A128148ICTSPIKMFKYCPYEKYAWVEEEE---S--SSHHHHHHHHHHxbbbxxaxaaaaaaaaaaaaa
1vhc_A_171vhc   A1838VPVIALDNADDILPLADTLAKEEEE--SSGGGHHHHHHHHHHbwbbbbabaaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1fq0_A_171fq0   A     CITCITRIC ACID V - 20
1gca_*_621gca   *     GALD-GALACTOSE N - 66
1gca_*_621gca   *     CACALCIUM ION N - 66
1gca_*_621gca   *     GALD-GALACTOSE L - 67
1gca_*_621gca   *     CACALCIUM ION L - 67
1q92_A_1241q92   A     DRM{[(1R,2S)-2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL) CYCLOPENTYL]OXY}METHYLPHOSPHONIC ACID C - 129
1q92_A_1241q92   A     DRM{[(1R,2S)-2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL) CYCLOPENTYL]OXY}METHYLPHOSPHONIC ACID T - 130
1q92_A_1241q92   A     DRM{[(1R,2S)-2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL) CYCLOPENTYL]OXY}METHYLPHOSPHONIC ACID S - 131
1q92_A_1241q92   A     DRM{[(1R,2S)-2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL) CYCLOPENTYL]OXY}METHYLPHOSPHONIC ACID P - 132
1q92_A_1241q92   A     DRM{[(1R,2S)-2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL) CYCLOPENTYL]OXY}METHYLPHOSPHONIC ACID I - 133
1q92_A_1241q92   A     DRM{[(1R,2S)-2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL) CYCLOPENTYL]OXY}METHYLPHOSPHONIC ACID C - 139
1q92_A_1241q92   A     DRM{[(1R,2S)-2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL) CYCLOPENTYL]OXY}METHYLPHOSPHONIC ACID K - 143

Clusters included in this Subclass
CLUSTER: EH.6.111
CLUSTER: EH.7.35