ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 3.23.1

Subclass Accession number: 1224
Subclass: 3.23.1

Type: EH beta-alpha
DB: ArchDB40

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 6.3 (>75 %)
GO : GO:0005524 (>75 %)  GO:0016614 (>75 %)  GO:0016874 (>75 %)  GO:0016879 (>75 %)  GO:0016884 (>75 %)
SCOP : 51734 (>75 %)  51735 (>75 %)  51800 (>75 %)  52373 (>75 %)  52402 (>75 %)  52403 (>75 %)

Number of loops: 8

Average sequence ID (%) : 29.4 +/- 22.5
Average RMSD (Å) : 0.613 +/- 0.280

Consensus geometry

d (Å): 9

delta (°): 45-90

theta (°): 135-180

rho (°): 90-135

Consensus Sequence:	hhGhGXh
(φψ)-conformation:	bblpbaa

Pattern:	x	[ivy]	[AGLV]	[HIV]	[ailv]	[G]	[lvy]	[GN]	x	[CFILPVY]	[agm]	x	x
Conservation:	-0.589	-0.064	-0.139	0.351	-0.254	2.588	-0.211	1.567	-0.865	-0.620	-0.364	-0.726	-0.672

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1b7g_O_2	1b7g	O	3	15	NVAVNGYGTIGKR	EEEEE--SHHHHH	xbxbxSxbaaaaa
1gr0_A_16	1gr0	A	17	29	RVAIVGVGNCASS	EEEEE--SHHHHH	xbbbbvxbaaaaa
1h2b_A_189	1h2b	A	189	201	YVAIVGVGGLGHI	EEEEE--SHHHHH	bbxbbSxbaaaaa
1h6d_A_84	1h6d	A	85	97	GYAIVGLGKYALN	EEEEE--SHHHHH	xbbxbvxbaaaaa
1hyh_A_23	1hyh	A	23	35	KIGIIGLGNVGAA	EEEEE--SHHHHH	bbbbbSxbaaaaa
1lj8_A_27	1lj8	A	28	40	GIAHIGVGGFHRA	EEEEE--SHHHHH	abbbxvxbaaaaa
1pdo_*_87	1pdo	-	87	99	YEVIAGVNIPMLV	EEEEES--HHHHH	bbbbxvpbaaaaa
1vjp_A_2	1vjp	A	3	15	KVLILGQGYVAST	EEEEE--SHHHHH	xbbbbvxbaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1gr0_A_16	1gr0	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	V - 21
1gr0_A_16	1gr0	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 22
1gr0_A_16	1gr0	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	V - 23
1gr0_A_16	1gr0	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 24
1gr0_A_16	1gr0	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	N - 25
1gr0_A_16	1gr0	A	ZNZINC ION	N - 25
1gr0_A_16	1gr0	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	C - 26
1gr0_A_16	1gr0	A	ZNZINC ION	C - 26
1gr0_A_16	1gr0	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	A - 27
1h2b_A_189	1h2b	A	NAJNICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM)	V - 193
1h2b_A_189	1h2b	A	NAJNICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM)	G - 194
1h2b_A_189	1h2b	A	NAJNICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM)	V - 195
1h2b_A_189	1h2b	A	NAJNICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM)	G - 196
1h2b_A_189	1h2b	A	NAJNICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM)	G - 197
1h2b_A_189	1h2b	A	NAJNICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM)	L - 198
1h2b_A_189	1h2b	A	ZNZINC ION	L - 198
1h2b_A_189	1h2b	A	NAJNICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM)	G - 199
1h6d_A_84	1h6d	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	V - 89
1h6d_A_84	1h6d	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	G - 90
1h6d_A_84	1h6d	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	L - 91
1h6d_A_84	1h6d	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	G - 92
1h6d_A_84	1h6d	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	K - 93
1h6d_A_84	1h6d	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	Y - 94
1h6d_A_84	1h6d	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	A - 95
1hyh_A_23	1hyh	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	I - 27
1hyh_A_23	1hyh	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 28
1hyh_A_23	1hyh	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	L - 29
1hyh_A_23	1hyh	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 30
1hyh_A_23	1hyh	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	N - 31
1hyh_A_23	1hyh	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	V - 32
1hyh_A_23	1hyh	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 33
1lj8_A_27	1lj8	A	MSESELENOMETHIONINE	I - 29
1lj8_A_27	1lj8	A	MSESELENOMETHIONINE	H - 31
1lj8_A_27	1lj8	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	I - 32
1lj8_A_27	1lj8	A	MSESELENOMETHIONINE	V - 34
1lj8_A_27	1lj8	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	V - 34
1lj8_A_27	1lj8	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 35
1lj8_A_27	1lj8	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 36
1lj8_A_27	1lj8	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	F - 37
1lj8_A_27	1lj8	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	H - 38
1vjp_A_2	1vjp	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	L - 7
1vjp_A_2	1vjp	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 8
1vjp_A_2	1vjp	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	Q - 9
1vjp_A_2	1vjp	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	G - 10
1vjp_A_2	1vjp	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	Y - 11
1vjp_A_2	1vjp	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	V - 12
1vjp_A_2	1vjp	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	A - 13

PDB Site Annotated loops in this subclass

Loop	PDB	Chain	Site	Residue
1h2b_A_189	1h2b	A	NJ1COFACTOR BINDING SITE FOR CHAIN A	G - 197
1h6d_A_84	1h6d	A	AC1NDP BINDING SITE FOR CHAIN A	G - 90
1h6d_A_84	1h6d	A	AC1NDP BINDING SITE FOR CHAIN A	L - 91
1h6d_A_84	1h6d	A	AC1NDP BINDING SITE FOR CHAIN A	G - 92
1h6d_A_84	1h6d	A	AC1NDP BINDING SITE FOR CHAIN A	K - 93
1h6d_A_84	1h6d	A	AC1NDP BINDING SITE FOR CHAIN A	Y - 94

Clusters included in this Subclass

CLUSTER: EH.2.107

CLUSTER: EH.3.171

CLUSTER: EH.4.116