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Information on SUBCLASS 3.27.1
Subclass Accession number: 1229
Subclass: 3.27.1 PSSM
Type: EH beta-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 1 (>75 %)  1.5 (>75 %)  1.5.1 (>75 %)  1.5.1.32.6 (>75 %)  2.6.1 (>75 %)  3.1 (>75 %)  3.1.1 (>75 %)  
GO : GO:0004091 (>75 %)  GO:0004104 (>75 %)  GO:0004146 (>75 %)  GO:0008483 (>75 %)  GO:0016645 (>75 %)  GO:0016646 (>75 %)  GO:0016769 (>75 %)  GO:0016788 (>75 %)  GO:0016789 (>75 %)  GO:0016829 (>75 %)  GO:0016846 (>75 %)  GO:0016847 (>75 %)  
SCOP : 53382 (>75 %)  53383 (>75 %)  53384 (>75 %)  53473 (>75 %)  53474 (>75 %)  53475 (>75 %)  53596 (>75 %)  53597 (>75 %)  53598 (>75 %)  
Number of loops: 5

Average sequence ID (%) : 37.5 +/- 23.7
Average RMSD (Å) : 0.200 +/- 0.071

Consensus geometry
d (Å): 11 delta (°): 0-45 theta (°): 135-180 rho (°): 90-135
Consensus Sequence: hhhGGhp
(φψ)-conformation: bpaewaa
Pattern: [ILV][FMVW][IV][AIV][G][G][AGS][EQRS][ILV][FY][EKNT][AEQ]
Conservation:-0.119-0.9090.287-0.5481.6691.669-0.629-0.762-0.1061.257-0.952-0.856
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1aoe_A_1061aoe   A109120VFIIGGAEIYNEEEE---HHHHHHbbxaewaaaaaa
1kmv_A_1091kmv   A112123VWIVGGSSVYKEEEE---HHHHHHbbxaewaaaaaa
1ra9_*_911ra9   -91102IMVIGGGRVYEQEEE---HHHHHHbbxaewaaaaaa
3dfr_*_943dfr   -94105LVIAGGAQIFTAEEE---HHHHHHxbxaewaaaaaa
4cd2_A_1154cd2   A120131IFVIGGAQLYKAEEE---HHHHHHbbxaewaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1aoe_A_1061aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE I - 111
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE I - 112
1aoe_A_1061aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE I - 112
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 113
1aoe_A_1061aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE G - 113
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 114
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 115
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE E - 116
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE I - 117
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Y - 118
1aoe_A_1061aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE Y - 118
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE E - 120
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 121
1kmv_A_1091kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE I - 114
1kmv_A_1091kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE V - 115
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE V - 115
1kmv_A_1091kmv   A     DMSDIMETHYL SULFOXIDE V - 115
1kmv_A_1091kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE G - 116
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 116
1kmv_A_1091kmv   A     DMSDIMETHYL SULFOXIDE G - 116
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 117
1kmv_A_1091kmv   A     DMSDIMETHYL SULFOXIDE G - 117
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE S - 118
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE S - 119
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE V - 120
1kmv_A_1091kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE Y - 121
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Y - 121
1kmv_A_1091kmv   A     DMSDIMETHYL SULFOXIDE Y - 121
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE E - 123
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 95
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 96
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 97
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE R - 98
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE V - 99
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Y - 100
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Q - 102
3dfr_*_943dfr   *     MTXMETHOTREXATE I - 96
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 97
3dfr_*_943dfr   *     MTXMETHOTREXATE A - 97
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 98
3dfr_*_943dfr   *     MTXMETHOTREXATE G - 98
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 99
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 100
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Q - 101
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE I - 102
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE F - 103
3dfr_*_943dfr   *     MTXMETHOTREXATE F - 103
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 105
4cd2_A_1154cd2   A     FOLFOLIC ACID V - 122
4cd2_A_1154cd2   A     FOLFOLIC ACID I - 123
4cd2_A_1154cd2   A     FOLFOLIC ACID G - 124
4cd2_A_1154cd2   A     FOLFOLIC ACID Y - 129
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
4cd2_A_1154cd2   A S1THE BINDING ORIENTATION OF THE PTERIDINE RING OF FOL IN THIS STRUCTURE IS SIMILAR TO THAT OBSERVED IN HDHFR FA BINARY COMPLEXES.I - 123

Clusters included in this Subclass
CLUSTER: EH.2.117