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Information on SUBCLASS 4.33.2
Subclass Accession number: 1327
Subclass: 4.33.2 PSSM
Type: EH beta-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 1.1 (>75 %)  1.1.1 (>75 %)  
GO : GO:0004420 (>50 %)  GO:0016614 (>75 %)  GO:0016616 (>75 %)  
SCOP : 56541 (>50 %)  56542 (>50 %)  56543 (>50 %)  
 Number of loops: 3

Average sequence ID (%) : 14.0 +/- 16.0
Average RMSD (Å) : 0.700 +/- 0.300

Consensus geometry
d (Å): 9 delta (°): 45-90 theta (°): 135-180 rho (°): 0-45
Consensus Sequence: hXXXXXhh
(φψ)-conformation: bbappgaa
Pattern: [V][PV][LM][AFV][DTV]xxx[CNS][ILM][PV]x[AGS][AKT][ANS]xx[ACT][KRS]
Conservation:2.5370.8961.705-0.773-0.891-1.2460.027-0.773-0.1821.0000.0080.1470.173-0.536-0.064-1.009-1.3640.1730.173
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1hwl_A_5491hwl   A553571VPMATTEGCLVASTNRGCREEEE--STTHHHHHHHHHHxwbxbaxxvaaaaaaaaaa
1r7i_A_771r7i   A7795VPLVVEEPSIVAAASYMAKEEEE-S-TTHHHHHHHHHHbwbbbaxxgaaaaaaaaaa
1t2d_A_291t2d   A3048VVLFDIVKNMPHGKALDTSEEEE-SSSSHHHHHHHHHHbbxxbaxxgaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1hwl_A_5491hwl   A     FBI7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID E - 559
1hwl_A_5491hwl   A     FBI7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID G - 560
1hwl_A_5491hwl   A     FBI7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID C - 561
1hwl_A_5491hwl   A     FBI7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID L - 562
1hwl_A_5491hwl   A     ADPADENOSINE-5'-DIPHOSPHATE V - 563
1hwl_A_5491hwl   A     ADPADENOSINE-5'-DIPHOSPHATE A - 564
1hwl_A_5491hwl   A     FBI7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID A - 564
1hwl_A_5491hwl   A     ADPADENOSINE-5'-DIPHOSPHATE S - 565
1hwl_A_5491hwl   A     FBI7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID S - 565
1hwl_A_5491hwl   A     ADPADENOSINE-5'-DIPHOSPHATE N - 567
1hwl_A_5491hwl   A     ADPADENOSINE-5'-DIPHOSPHATE R - 568
1hwl_A_5491hwl   A     FBI7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID R - 568
1hwl_A_5491hwl   A     ADPADENOSINE-5'-DIPHOSPHATE G - 569
1hwl_A_5491hwl   A     ADPADENOSINE-5'-DIPHOSPHATE R - 571
1t2d_A_291t2d   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE F - 33
1t2d_A_291t2d   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE D - 34
1t2d_A_291t2d   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE I - 35
1t2d_A_291t2d   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE V - 36
1t2d_A_291t2d   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE M - 39

Clusters included in this Subclass
CLUSTER: EH.6.129