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Information on SUBCLASS 8.1.1
Subclass Accession number: 143
Subclass: 8.1.1
Type: HE alpha-beta
DB: ArchDB-KI
Number of loops: 22

Average sequence ID (%) : 35.1 +/- 4.4
Average RMSD (Å) : 0.85 +/- 0.42

Consensus geometry
d (Å): 7 delta (°): 90-135 theta (°): 90-135 rho (°): 135-180
Consensus Sequence: pXhpHXphhpLX
(φψ)-conformation: aapbbaabppba
Pattern: {ILMV}{KLM}{HKNQS}x{AFGILV}{HKNQRT}{H}x{HKNRT}[ILV][ILV]{HKNQRS}[IL]xxx
Conservation:0.4740.262-0.566-1.406-0.873-0.3811.747-0.379-0.2441.1631.349-0.5341.664-1.015-0.945-0.317
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a06_*_651a06   -6984VLHKIKHPNIVALDDIHHHT---TTB--EEEEaaaaxbbaabxxbabb
1ad5_A_3041ad5   A313328VMKTLQHDKLVKLHAVHHTT---TTB--EEEEaaaaxxbaabxxxabb
1apm_E_851apm   E94109ILQAVNFPFLVKLEFSHHHH---TTB--EEEEaaaaxbbaabxxxabb
1aq1_*_461aq1   -5469LLKELNHPNIVKLLDVHHTT---TTB--EEEEaaaaxbbaabpxxabb
1b38_A_461b38   A5469LLKELNHPNIVKLLDVHHTT---TTB--EEEEaaaaxbbaabpxxabb
1cdk_A_851cdk   A94109ILQAVNFPFLVKLEYSHHHH---TTB--EEEEaaaaxbbaabxxxabb
1ckp_*_461ckp   -5469LLKELNHPNIVKLLDVHHTT---TTB--EEEEaaaaxbbaabpxxabb
1erk_*_601erk   -7287ILLRFRHENIIGINDIHHHH---TTB--EEEEaaaaxbbaabpbxabb
1fgk_A_5221fgk   A535550MKMIGKHKNIINLLGAHHHH---TTB--EEEEaaaaexbaabxxxaeb
1hcl_*_461hcl   -5469LLKELNHPNIVKLLDVHHTT---TTB--EEEEaaaaxbbaabxxxabb
1ir3_A_10381ir3   A10501065VMKGFTCHHVVRLLGVHHHT---TTB--EEEEaaaabbbaabpxxaeb
1irk_*_10381irk   -10501065VMKGFTCHHVVRLLGVHHTT---TTB--EEEEaaaabbbaabpbxaeb
1jnk_*_1021jnk   -114129LMKCVNHKNIISLLNVHHHH---TTB--EEEEaaaaxbbaabpxxabb
1jsu_A_461jsu   A5469LLKELNHPNIVKLLDVHHTT---TTB--EEEEaaaabxbaabpxxabb
1koa_*_59781koa   -59906005TMSVLRHPTLVNLHDAHHHHT--TTB--EEEEaaaaapbaabpxxabb
1kob_A_891kob   A101116IMNQLHHPKLINLHDAHHTT--STTB--EEEEaaaaaxbaabpxxabb
1phk_*_601phk   -7792LRKVSGHPNIIQLKDTHHHHTT-TTB--EEEEaaaapgxaabxbxabb
1tki_A_601tki   A7186ILNIARHRNILHLHESHHHHS--TTB--EEEEaaaaxxbaabpxxabb
1ydr_E_851ydr   E94109ILQAVNFPFLVKLEFSHHHH---TTB--EEEEaaaaxbbaabxxxabb
2ptk_*_3132ptk   -313328VMKKLRHEKLVQLYAVHHHH---TTB--EEEEaaaapbbaabpxxabb
2src_*_3042src   -313328VMKKLRHEKLVQLYAVHHHT---TTB--EEEEaaaaxbbaabxxxabb
3lck_*_2823lck   -291306LMKQLQHQRLVRLYAVHHHT---TTB--EEEEaaaabxbaabpxxabF
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ad5_A_3041ad5   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER V - 323
1apm_E_851apm   E     PHOPHEOPHYTIN A H - 87
1apm_E_851apm   E     PHOPHEOPHYTIN A N - 90
1apm_E_851apm   E     OCTN-OCTANE F - 100
1aq1_*_461aq1   *     STUSTAUROSPORINE V - 64
1b38_A_461b38   A     ATPADENOSINE-5'-TRIPHOSPHATE V - 64
1jsu_A_461jsu   A     TPOPHOSPHOTHREONINE R - 50
1phk_*_601phk   *     ATPADENOSINE-5'-TRIPHOSPHATE E - 73
1phk_*_601phk   *     MNMANGANESE (II) ION E - 73
1phk_*_601phk   *     ATPADENOSINE-5'-TRIPHOSPHATE I - 87
1ydr_E_851ydr   E     TPOPHOSPHOTHREONINE H - 87
1ydr_E_851ydr   E     TPOPHOSPHOTHREONINE N - 90
1ydr_E_851ydr   E     IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE V - 104
Bibliographic annotations
LoopPDBChainAnnotationResidue
1ad5_A_3041ad5   RefF.SICHERI,I.MOAREFI,J.KURIYAN. CRYSTAL STRUCTURE OF THE SRC FAMILY TYROSINE KINASE HCK  NATURE v.385;602,1997ACATALYTIC RESIDUE(SALT-INT-K295)E - 310
1apm_E_851apm   RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN *EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT  ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993EP-ATP BINDING RESIDUEE - 91
1fgk_A_5221fgk   RefM.MOHAMMADI, J.SCHLESSINGER, S.R.HUBBARD. STRUCTURE OF THE FGF RECEPTOR TYROSINE KINASE DOMAIN REVEALS A NOVEL AUTOINHIBITORY MECHANISM  CELL v.86;577,1996ACATALYTIC RESIDUE(SALT-IO-514Y)E - 531
1jsu_A_461jsu   RefA.A.RUSSO,P.D.JEFFREY,A.K.PATTEN,J.MASSAGUE,N.P.PAVLETICH. CRYSTAL STRUCTURE OF THE P27KIP1 CYCLIN-DEPENDENT-KINASE INHIBITOR BOUND TO THE CYCLIN A-CDK2 COMPLEX  NATURE v.382;325,1996AP27 PROTEIN BINDING RESIDUEL - 67
1jsu_A_461jsu   RefA.A.RUSSO,P.D.JEFFREY,A.K.PATTEN,J.MASSAGUE,N.P.PAVLETICH. CRYSTAL STRUCTURE OF THE P27KIP1 CYCLIN-DEPENDENT-KINASE INHIBITOR BOUND TO THE CYCLIN A-CDK2 COMPLEX  NATURE v.382;325,1996AP27 PROTEIN BINDING RESIDUEI - 70
1kob_A_891kob   RefB.KOBE,J.HEIERHORST,S.C.FEIL,M.W.PARKER,G.M.BENIAN,K.R.WEISS,B.E.KEMP. GIANT PROTEIN KINASES: DOMAIN INTERACTIONS AND STRUCTURAL BASIS OF AUTOREGULATION  EMBO J. v.15;6810,1996ACATALYTIC RESIDUEE - 98

Clusters included in this Subclass
CLUSTER: HE.7.0
CLUSTER: HE.8.0
CLUSTER: HE.9.0
CLUSTER: HE.9.1
CLUSTER: HE.9.5