ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 11.1.1

Subclass Accession number: 195
Subclass: 11.1.1
Type: HH alpha-alpha
DB: ArchDB-KI

Number of loops: 11

Average sequence ID (%) : 34.0 +/- 6.8
Average RMSD (Å) : 1.29 +/- 0.70

Consensus geometry

d (Å): 23

delta (°): 45-90

theta (°): 45-90

rho (°): 225-270

Consensus Sequence:	XXXhphXXPpphXpp
(φψ)-conformation:	aagpbppppplppaa

Pattern:	{LV}	[FILV]	{DKRY}	x	{LV}	{EKM}	{DEKR}	{G}	{GY}	[KRY]	[LMV]	{DP}	x	[P]	{DPS}	{EHN}	[CF]	[PST]	{ENS}	{DERS}	[LV]	[HKTY]	{DEN}	[ILMV]	[LM]	x	{DNQR}	[CL]
Conservation:	-0.396	0.035	-1.027	-1.302	-0.472	-0.846	-0.910	1.051	-0.245	-0.016	0.551	-0.361	-1.285	3.057	-0.368	-0.161	1.707	0.198	-0.446	-0.673	0.424	-0.369	-0.262	0.296	1.152	-0.545	-0.646	1.857

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1ad5_A_469	1ad5	A	471	498	VIRALERGYRMPRPENCPEELYNIMMRC	HHHHHHTT------TTS-HHHHHHHHHH	aaaaaaavxbxxxpaaxxaaaaaaaaaa
1apm_E_243	1apm	E	245	272	QIYEKIVSGKVRFPSHFSSDLKDLLRNL	HHHHHHHHT-----TTS-HHHHHHHHHH	aaaaaaaavbbbbxaaxxaaaaaaaaaa
1byg_A_395	1byg	A	395	422	VVPRVEKGYKMDAPDGCPPAVYEVMKNC	HHHHHTTT------TT--HHHHHHHHHH	aaaaaaagpbxxxppvpxaaaaaaaaaa
1cdk_A_243	1cdk	A	245	272	QIYEKIVSGKVRFPSHFSSDLKDLLRNL	HHHHHHHH------TTS-HHHHHHHHHH	aaaaaaaavxbbxxaaxxaaaaaaaaaa
1fgk_A_706	1fgk	A	709	736	LFKLLKEGHRMDKPSNCTNELYMMMRDC	HHHHHHTT------SS--HHHHHHHHHH	aaaaaaavxbpxxxxvbxaaaaaaaaaa
1ir3_A_1215	1ir3	A	1218	1245	VLKFVMDGGYLDQPDNCPERVTDLMRMC	HHHHHHTT------TT--HHHHHHHHHH	aaaaaaagxbxxxxplxpaaaaaaaaaa
1irk_*_1215	1irk	-	1218	1245	VLKFVMDGGYLDQPDNCPERVTDLMRMC	HHHHHHTT------SS--HHHHHHHHHH	aaaaaaagxbxxpxxlb-aaaaaaaaaa
1ydr_E_243	1ydr	E	245	272	QIYEKIVSGKVRFPSHFSSDLKDLLRNL	HHHHHHHTT-----TTS-HHHHHHHHHH	aaaaaaaavbbbbpaaxxaaaaaaaaaa
2fgi_A_706	2fgi	A	709	736	LFKLLKEGHRMDKPSNCTNELYMMMRDC	HHHHHHHT------SS--HHHHHHHHHH	aaaaaaavxbpxxxxlbxaaaaaaaaaa
2ptk_*_468	2ptk	-	471	498	VLDQVERGYRMPCPPECPESLHDLMCQC	HHHHHHTT------TTS-HHHHHHHHHH	aaaaaaagxbpxxppUxpaaaaaaaaaa
2src_*_468	2src	-	471	498	VLDQVERGYRMPCPPECPESLHDLMCQC	HHHHHHTT------TT--HHHHHHHHHH	aaaaaaagxbxxpxpvxxaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Bibliographic annotations

Loop	PDB	Chain	Annotation	Residue
1fgk_A_706	1fgk RefM.MOHAMMADI, J.SCHLESSINGER, S.R.HUBBARD. STRUCTURE OF THE FGF RECEPTOR TYROSINE KINASE DOMAIN REVEALS A NOVEL AUTOINHIBITORY MECHANISM CELL v.86;577,1996	A	PHOSPHORYLATION SITE	Y - 730
1ir3_A_1215	1ir3 RefS.R.HUBBARD. CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. v.16;5572,1997	A	SUBSTRATE BINDING RESIDUE	N - 1215
1ir3_A_1215	1ir3 RefS.R.HUBBARD. CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. v.16;5572,1997	A	SUBSTRATE BINDING RESIDUE	E - 1216
1ir3_A_1215	1ir3 RefS.R.HUBBARD. CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. v.16;5572,1997	A	SUBSTRATE BINDING RESIDUE	L - 1219

Clusters included in this Subclass