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Information on SUBCLASS 2.1.31
Subclass Accession number: 2190
Subclass: 2.1.31 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 2.3 (>75 %)  2.3.1 (>75 %)  3.1 (>75 %)  3.1.4 (>75 %)  3.1.4.17
GO : GO:0008081 (>75 %)  GO:0008415 (>75 %)  GO:0016746 (>75 %)  GO:0016747 (>75 %)  GO:0016788 (>75 %)  GO:0042578 (>75 %)  
SCOP : 48546 (>75 %)  48547 (>75 %)  48548 (>75 %)  51160 (>75 %)  51161 (>75 %)  51168 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 23.9 +/- 17.8
Average RMSD (Å) : 0.600 +/- 0.265

Consensus geometry
d (Å): 17 delta (°): 0-45 theta (°): 45-90 rho (°): 270-315
Consensus Sequence: hXKXXX
(φψ)-conformation: aappaa
Pattern: x[HNT][DQ][KR]xx[FV][CL][AQR]x[CLM][IMV][HKT][ACL][AC][D][IL][NS][AGN][IP][AT][K][PSV]x[DEP][IL][HQY]x[KQR][LW][AT][DE]x[IV][AMV][ENT][E][F][FY]
Conservation:-1.103-0.3640.4160.774-1.251-0.687-0.329-0.063-0.733-1.103-0.2900.079-0.881-0.6600.2562.3690.4300.293-0.733-0.3430.0951.704-1.251-1.177-0.2900.4190.005-1.0290.0791.0200.0620.881-1.6940.729-0.660-0.5861.7042.3691.539
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1f0j_A_3771f0j   A377415YTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFHHHHHHHHHHHHHHHHT-GGGS-HHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaaxpaaaaaaaaaaaaaaaa
1rkp_A_7491rkp   A749787PHQKELFLAMLMTACDLSAITKPWPIQQRLAELVATEFFHHHHHHHHHHHHHHHHTGGGGS-HHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaaxwaaaaaaaaaaaaaaaa
1so2_A_9221so2   A922960ENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYHHHHHHHHHHHHHHHHT-GGGS-HHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaabpaaaaaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1f0j_A_3771f0j   A     ZNZINC ION D - 392
1f0j_A_3771f0j   A     MGMAGNESIUM ION D - 392
1f0j_A_3771f0j   A     ARSARSENIC D - 392
1f0j_A_3771f0j   A     ARSARSENIC L - 393
1f0j_A_3771f0j   A     ARSARSENIC I - 410
1f0j_A_3771f0j   A     ARSARSENIC F - 414
1rkp_A_7491rkp   A     ZNZINC ION D - 764
1rkp_A_7491rkp   A     MGMAGNESIUM ION D - 764
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE D - 764
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE L - 765
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE S - 766
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE A - 767
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE I - 768
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE Q - 775
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE L - 778
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE A - 779
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE V - 782
1rkp_A_7491rkp   A     IBM3-ISOBUTYL-1-METHYLXANTHINE F - 786
1so2_A_9221so2   A     MGMAGNESIUM ION D - 937
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE D - 937
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE I - 938
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE N - 939
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE G - 940
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE P - 941
1so2_A_9221so2   A     HG91-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL R - 945
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE L - 947
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE H - 948
1so2_A_9221so2   A     HG91-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL L - 949
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE L - 949
1so2_A_9221so2   A     HG91-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL K - 950
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE W - 951
1so2_A_9221so2   A     HG91-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL T - 952
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE T - 952
1so2_A_9221so2   A     HG91-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL E - 953
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE I - 955
1so2_A_9221so2   A     HG91-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL V - 956
1so2_A_9221so2   A     HG91-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL N - 957
1so2_A_9221so2   A     6666-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO} PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE F - 959
1so2_A_9221so2   A     HG91-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL Y - 960
1so2_A_9221so2   A     MGMAGNESIUM ION D - 964
1so2_A_9221so2   A     MGMAGNESIUM ION A - 967
1so2_A_9221so2   A     MGMAGNESIUM ION N - 968

Clusters included in this Subclass
CLUSTER: HH.6.153