ArchDB - Biological DataBase of Protein Loops

Grup de Recerca en Informàtica Biomèdica

Information on SUBCLASS 4.6.1

Subclass Accession number: 2382
Subclass: 4.6.1

PSSM

Type: HH alpha-alpha
DB: ArchDB40

Image coordinates:

Rasmol PDB

Jmol PDB

Consensus coordinates:

Rasmol PDB

Jmol PDB

Conserved Annotation
EC : 2.7.1 (>75 %)  2.7.1.112 (>75 %)
GO : GO:0004672 (>75 %)  GO:0016301 (>75 %)  GO:0016773 (>75 %)
SCOP : 56111 (>75 %)  56112 (>75 %)  88854 (>75 %)

Number of loops: 13

Average sequence ID (%) : 12.4 +/- 12.8
Average RMSD (Å) : 0.908 +/- 0.233

Consensus geometry

d (Å): 13

delta (°): 90-135

theta (°): 135-180

rho (°): 315-360

Consensus Sequence:	XXchppXX
(φψ)-conformation:	aalpapaa

Pattern:	x	x	x	x	x	[ailmt]	x	x	x	[DEGKQ]	x	[adknrst]	[DGKRS]	x	[egknqs]	x	[fhil]	x
Conservation:	-1.278	-0.256	-0.317	-0.335	-1.167	0.882	-0.829	-0.120	-1.418	2.168	0.062	1.007	1.482	-0.491	0.271	-0.857	1.125	0.072

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1bkp_A_65	1bkp	A	70	87	KELLWIWQLKSNDVNDLN	HHHHHHHTS---BHHHHH	aaaaaaaaalbaxaaaaa
1csh_*_209	1csh	-	209	226	WSHNFTNMLGYTDPQFTE	HHHHHHHHHT---HHHHH	aaaaaaaaavbapaaaaa
1e5k_A_142	1e5k	A	144	161	PLLLEYLQAGERRVMVFM	HHHHHHHHTT---HHHHH	aaaaaaaaavxaxaaaaa
1efu_B_86	1efu	B	94	111	KVLDAAVAGKITDVEVLK	HHHHHHHHTT---HHHHH	aaaaaaaaalxaxaaaaa
1is2_A_56	1is2	A	69	86	TMVKKMREYGISDPEEIM	HHHHHHHHHT--SHHHHH	aaaaaaaaavxapaaaaa
1izm_A_21	1izm	A	26	43	GFLSGLLCGGLKDQSWLP	HHHHHHHHTT--STTHHH	aaaaaaaaavxabaaaaa
1k6w_A_327	1k6w	A	330	347	VLHMGLHVCQLMGYGQIN	HHHHHHHHTT--SHHHHH	aaaaaaaaalxaxaaaaa
1kcx_A_202	1kcx	A	207	224	QEQKRILEMGITGPEGHA	HHHHHHHHTT--STHHHH	aaaaaaaaavxaxaaaaa
1kl9_A_91	1kl9	A	110	127	ILRHVAEVLEYTKDEQLE	HHHHHHHHTT--SHHHHH	aaaaaaaaalxabaaaaa
1p35_A_111	1p35	A	114	131	KFAKILKSHDYTDKKSIE	HHHHHHHHTT--SHHHHH	aaaaaaaaavxaxaaaaa
1qgi_A_149	1qgi	A	151	168	YSVEQARQRGFTSAVTIG	HHHHHHHHTT---HHHHH	aaaaaaaaavbaxaaaaa
1r9l_A_262	1r9l	A	266	283	NAQNAIMHDGKASEGDIQ	HHHHHHHHHT--SHHHHH	aaaaaaaaaNbaxaaaaa
1uby_*_221	1uby	-	223	240	PVAAAMYMVGIDSKEEHE	HHHHHHHHHT---HHHHH	aaaaaaaaagxapaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1izm_A_21	1izm	A	MSESELENOMETHIONINE	A - 21
1izm_A_21	1izm	A	MSESELENOMETHIONINE	L - 24
1izm_A_21	1izm	A	MSESELENOMETHIONINE	C - 33
1kl9_A_91	1kl9	A	MSESELENOMETHIONINE	A - 94
1kl9_A_91	1kl9	A	MSESELENOMETHIONINE	C - 97
1kl9_A_91	1kl9	A	MSESELENOMETHIONINE	E - 98
1kl9_A_91	1kl9	A	MSESELENOMETHIONINE	F - 101
1kl9_A_91	1kl9	A	ZNZINC ION	H - 113
1kl9_A_91	1kl9	A	ZNZINC ION	E - 116
1qgi_A_149	1qgi	A	GCSD-GLUCOSAMINE	L - 175
1qgi_A_149	1qgi	A	GCSD-GLUCOSAMINE	N - 176

PDB Site Annotated loops in this subclass

Loop	PDB	Chain	Site	Residue
1e5k_A_142	1e5k	A	CI1CITRIC ACID BINDING SITE FOR RESIDUE 302	R - 155
1e5k_A_142	1e5k	A	CI1CITRIC ACID BINDING SITE FOR RESIDUE 302	R - 156
1e5k_A_142	1e5k	A	CI1CITRIC ACID BINDING SITE FOR RESIDUE 302	M - 158

Clusters included in this Subclass

CLUSTER: HH.4.132

CLUSTER: HH.5.19

CLUSTER: HH.6.19