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Information on SUBCLASS 5.2.1
Subclass Accession number: 2438
Subclass: 5.2.1 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 31

Average sequence ID (%) : 12.4 +/- 13.8
Average RMSD (Å) : 0.855 +/- 0.296

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 90-135 rho (°): 315-360
Consensus Sequence: pXXhphpXX
(φψ)-conformation: aabaappaa
Pattern: [acfilmvy]xx[afilvy]x[adekqrst]xx[aimpv][dehknqrstw][AGILMVWY][degnpst]x[adegkqrs][adegqrst][afiklv]x[adegknqrst]x[afgilmvwy]
Conservation:0.274-0.749-1.3501.004-0.1830.384-0.396-0.5622.7930.2440.1091.303-1.490-0.1200.2330.764-1.1040.230-1.013-0.372
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
153l_*_110153l   -124143IKTIQKKFPSWTKDQQLKGGHHHHHHH-TTS-HHHHHHHHaaaaaaabaaxxaaaaaaaa
1bja_A_341bja   A3453AAEVREVHPDLGNAVVNSNIHHHHHHT-TTS-HHHHHHHHaaaaaaabaabxaaaaaaaa
1dj8_A_521dj8   A6281IVQACTQDKQANFKDKVKGEHHHHHHTTTTSBHHHHHHHHaaaaaaabaapxaaaaaaaa
1dnp_A_3591dnp   A363382ERYFMSQLIDGDLAANNGGWHHHHHTT-TT--HHHHHHHHaaaaaaaxaapbaaaaaaaa
1ea5_A_3491ea5   A353372MSGVKLSVPHANDLGLDAVTHHHHHHHSTT--HHHHHHHHaaaaaaabaaxxaaaaaaaa
1fcq_A_1271fcq   A134153VEVVRREHPFWDDQRVEQEAHHHHHHH-TTS-HHHHHHHHaaaaaaabaaxxaaaaaaaa
1fpz_A_1461fpz   A152171ACLLLYLSDTISPEQAIDSLHHHHHHH-SS--HHHHHHHHaaaaaaabaaxxaaaaaaaa
1gci_*_2201gci   -231250AALVKQKNPSWSNVQIRNHLHHHHHHH-TT--HHHHHHHHaaaaaaabaaxxaaaaaaaa
1gqi_A_4591gqi   A465484AFGRMAWDHQISAATAADEWHHHHHHH-TT--HHHHHHHHaaaaaaabaaxxaaaaaaaa
1i1i_P_5481i1i   P561580VDQSLHTNATLDAASEYAKYHHHHTTT-SS--HHHHHHHHaaaaaaabNaxxaaaaaaaa
1jdr_A_861jdr   A92111LEPIHKEFPWISSGDLFSLGHHHHHHH-TTS-HHHHHHHHaaaaaaabaaxxaaaaaaaa
1kjw_A_6551kjw   A655674LENVLEINKRITEEQARKAFHHHHHHH-TTS-HHHHHHHHaaaaaaabaabxaaaaaaaa
1kk8_A_5291kk8   A532551ILEEECMFPKADDKSFQDKLHHHHHTT-TT--HHHHHHHHaaaaaaabaaxbaaaaaaaa
1kxp_D_2281kxp   D236255LIKLAQKVPTADLEDVLPLAHHHHHHH-TTS-HHHHHHHHaaaaaaabaaxxaaaaaaaa
1kxp_D_371kxp   D4564LVLYSRKFPSGTFEQVSQLVHHHHHHH-TT--HHHHHHHHaaaaaaabaaxxaaaaaaaa
1kxp_D_4151kxp   D423442AERLKAKLPDATPKELAKLVHHHHHHH-TTS-HHHHHHHHaaaaaaabaapxaaaaaaaa
1llf_A_3551llf   A359378RAYFKQSFIHASDAEIDTLMHHHHHHH-TT--HHHHHHHHaaaaaaabaaxxaaaaaaaa
1n3l_A_751n3l   A7594DLHAYLDNMKAPWELLELRVHHHHHHTTTTS-HHHHHHHHaaaaaaabaappaaaaaaaa
1n5u_A_2081n5u   A216235VARLSQRFPKAEFAEVSKLVHHHHHHH-TTS-HHHHHHHHaaaaaaabaaxxaaaaaaaa
1n5u_A_3231n5u   A331350LYEYARRHPDYSVVLLLRLAHHHHHHT-TTS-HHHHHHHHaaaaaaabaabxaaaaaaaa
1n5u_A_4001n5u   A408427LVRYTKKVPQVSTPTLVEVSHHHHHHH-TTS-HHHHHHHHaaaaaaabaaxpaaaaaaaa
1n5u_A_5181n5u   A529548LVELVKHKPKATKEQLKAVMHHHHHHH-TT--HHHHHHHHaaaaaaabaaxxaaaaaaaa
1np7_A_3731np7   A377396AEWFESCLIDYDVCSNWGNWHHHHHHH-TT--HHHHHHHHaaaaaaaxaapbaaaaaaaa
1nrw_A_1151nrw   A123142LDRFRSANPEADLSVLKQAAHHHHHHH-TTS-HHHHHHHHgaaaaaabaaxxaaaaaaaa
1oaf_A_741oaf   A81100LEPLKAEFPILSYADFYQLAHHHHHHT-TTS-HHHHHHHHaaaaaaabaaxxaaaaaaaa
1owl_A_3681owl   A371390EQFFMQHLVDGDLAANNGGWHHHHHTT-TT--HHHHHHHHaaaaaaaxaapbaaaaaaaa
1q4g_A_2961q4g   A313332CDLLKAEHPTWGDEQLFQTAHHHHHHH-TT--HHHHHHHHaaaaaaabaaxxaaaaaaaa
1qst_A_601qst   A7089KNIFSRQLPKMPKEYIVKLVHHHHHHH-TTS-HHHHHHHHaaaaaaabaaxpaaaaaaaa
1r64_A_3841r64   A395414YTLLLEANPNLTWRDVQYLSHHHHHHH-TT--HHHHHHHHaaaaaaabaapxaaaaaaaa
1ucr_A_241ucr   A2443FNDFTDLFPDMKQREVKKILHHHHHHH-TTS-HHHHHHHHaaaaaaabaabxaaaaaaaa
6pax_A_786pax   A84103IAQYKQECPSIFAWEIRDRLHHHHHHH-TT--HHHHHHHHaaaaaaabaaxxaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE F - 366
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE M - 367
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE L - 370
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE D - 372
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE G - 373
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE D - 374
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE L - 375
1dnp_A_3591dnp   A     MHF5,10-METHENYL-6,7,8-TRIHYDROFOLIC ACID L - 375
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE A - 377
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE N - 378
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE N - 379
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE G - 380
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE G - 381
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE W - 382
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE W - 384
1dnp_A_3591dnp   A     FADFLAVIN-ADENINE DINUCLEOTIDE A - 385
1gci_*_2201gci   *     CACALCIUM ION R - 247
1gqi_A_4591gqi   A     COCOBALT (II) ION Q - 460
1gqi_A_4591gqi   A     EDO1,2-ETHANEDIOL R - 468
1gqi_A_4591gqi   A     EDO1,2-ETHANEDIOL W - 471
1gqi_A_4591gqi   A     EDO1,2-ETHANEDIOL D - 472
1gqi_A_4591gqi   A     EDO1,2-ETHANEDIOL I - 475
1gqi_A_4591gqi   A     EDO1,2-ETHANEDIOL E - 483
1llf_A_3551llf   A     NAGN-ACETYL-D-GLUCOSAMINE Q - 357
1llf_A_3551llf   A     NAGN-ACETYL-D-GLUCOSAMINE A - 358
1llf_A_3551llf   A     NAGN-ACETYL-D-GLUCOSAMINE A - 360
1llf_A_3551llf   A     NAGN-ACETYL-D-GLUCOSAMINE Y - 361
1llf_A_3551llf   A     F23TRICOSANOIC ACID Y - 361
1llf_A_3551llf   A     F23TRICOSANOIC ACID F - 362
1llf_A_3551llf   A     NAGN-ACETYL-D-GLUCOSAMINE Q - 364
1llf_A_3551llf   A     F23TRICOSANOIC ACID S - 365
1llf_A_3551llf   A     F23TRICOSANOIC ACID F - 366
1llf_A_3551llf   A     F23TRICOSANOIC ACID L - 377
1n5u_A_2081n5u   A     MYRMYRISTIC ACID R - 209
1n5u_A_2081n5u   A     MYRMYRISTIC ACID A - 210
1n5u_A_2081n5u   A     MYRMYRISTIC ACID F - 211
1n5u_A_2081n5u   A     MYRMYRISTIC ACID K - 212
1n5u_A_2081n5u   A     MYRMYRISTIC ACID A - 213
1n5u_A_2081n5u   A     MYRMYRISTIC ACID V - 216
1n5u_A_2081n5u   A     MYRMYRISTIC ACID F - 228
1n5u_A_2081n5u   A     MYRMYRISTIC ACID V - 231
1n5u_A_2081n5u   A     MYRMYRISTIC ACID S - 232
1n5u_A_2081n5u   A     MYRMYRISTIC ACID V - 235
1n5u_A_2081n5u   A     MYRMYRISTIC ACID T - 236
1n5u_A_3231n5u   A     MYRMYRISTIC ACID D - 324
1n5u_A_3231n5u   A     MYRMYRISTIC ACID V - 325
1n5u_A_3231n5u   A     MYRMYRISTIC ACID L - 327
1n5u_A_3231n5u   A     MYRMYRISTIC ACID G - 328
1n5u_A_3231n5u   A     MYRMYRISTIC ACID M - 329
1n5u_A_3231n5u   A     MYRMYRISTIC ACID L - 331
1n5u_A_3231n5u   A     MYRMYRISTIC ACID S - 342
1n5u_A_3231n5u   A     MYRMYRISTIC ACID V - 344
1n5u_A_3231n5u   A     MYRMYRISTIC ACID L - 345
1n5u_A_3231n5u   A     MYRMYRISTIC ACID L - 347
1n5u_A_3231n5u   A     MYRMYRISTIC ACID R - 348
1n5u_A_3231n5u   A     MYRMYRISTIC ACID A - 350
1n5u_A_3231n5u   A     MYRMYRISTIC ACID K - 351
1n5u_A_3231n5u   A     MYRMYRISTIC ACID E - 354
1n5u_A_4001n5u   A     MYRMYRISTIC ACID Y - 401
1n5u_A_4001n5u   A     MYRMYRISTIC ACID F - 403
1n5u_A_4001n5u   A     MYRMYRISTIC ACID N - 405
1n5u_A_4001n5u   A     MYRMYRISTIC ACID L - 407
1n5u_A_4001n5u   A     MYRMYRISTIC ACID R - 410
1n5u_A_4001n5u   A     MYRMYRISTIC ACID Y - 411
1n5u_A_4001n5u   A     MYRMYRISTIC ACID K - 414
1n5u_A_4001n5u   A     MYRMYRISTIC ACID V - 415
1n5u_A_4001n5u   A     MYRMYRISTIC ACID V - 418
1n5u_A_4001n5u   A     MYRMYRISTIC ACID S - 419
1n5u_A_4001n5u   A     MYRMYRISTIC ACID T - 422
1n5u_A_4001n5u   A     MYRMYRISTIC ACID L - 423
1n5u_A_4001n5u   A     MYRMYRISTIC ACID V - 426
1n5u_A_4001n5u   A     MYRMYRISTIC ACID L - 430
1n5u_A_4001n5u   A     MYRMYRISTIC ACID G - 431
1n5u_A_4001n5u   A     MYRMYRISTIC ACID V - 433
1n5u_A_4001n5u   A     MYRMYRISTIC ACID G - 434
1n5u_A_4001n5u   A     MYRMYRISTIC ACID C - 437
1n5u_A_5181n5u   A     MYRMYRISTIC ACID K - 525
1n5u_A_5181n5u   A     MYRMYRISTIC ACID Q - 526
1n5u_A_5181n5u   A     MYRMYRISTIC ACID A - 528
1n5u_A_5181n5u   A     MYRMYRISTIC ACID L - 529
1n5u_A_5181n5u   A     MYRMYRISTIC ACID L - 532
1n5u_A_5181n5u   A     MYRMYRISTIC ACID H - 535
1n5u_A_5181n5u   A     MYRMYRISTIC ACID V - 547
1n5u_A_5181n5u   A     MYRMYRISTIC ACID M - 548
1n5u_A_5181n5u   A     MYRMYRISTIC ACID D - 549
1n5u_A_5181n5u   A     MYRMYRISTIC ACID F - 551
1n5u_A_5181n5u   A     MYRMYRISTIC ACID A - 552
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE F - 380
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE L - 384
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE D - 386
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE Y - 387
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE D - 388
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE V - 389
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE S - 391
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE N - 392
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE W - 393
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE N - 395
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE W - 396
1np7_A_3731np7   A     FADFLAVIN-ADENINE DINUCLEOTIDE T - 399
1nrw_A_1151nrw   A     PO4PHOSPHATE ION R - 125
1nrw_A_1151nrw   A     CACALCIUM ION A - 129
1oaf_A_741oaf   A     ASCASCORBIC ACID I - 76
1oaf_A_741oaf   A     ASCASCORBIC ACID L - 80
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE F - 374
1owl_A_3681owl   A     PO4PHOSPHATE ION M - 375
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE M - 375
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE L - 378
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE D - 380
1owl_A_3681owl   A     PO4PHOSPHATE ION G - 381
1owl_A_3681owl   A     PO4PHOSPHATE ION D - 382
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE D - 382
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE L - 383
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE N - 386
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE N - 387
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE G - 388
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE G - 389
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE W - 390
1owl_A_3681owl   A     FADFLAVIN-ADENINE DINUCLEOTIDE W - 392
1q4g_A_2961q4g   A     GOLGLYCEROL L - 298
1q4g_A_2961q4g   A     GOLGLYCEROL L - 306
1q4g_A_2961q4g   A     GOLGLYCEROL R - 307
1q4g_A_2961q4g   A     GOLGLYCEROL N - 310
1q4g_A_2961q4g   A     GOLGLYCEROL R - 311
1q4g_A_2961q4g   A     GOLGLYCEROL C - 313
1q4g_A_2961q4g   A     GOLGLYCEROL D - 314
1qst_A_601qst   A     EPE4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID Q - 76
1qst_A_601qst   A     EPE4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID L - 77
1r64_A_3841r64   A     BOR(1R)-1-AMINO-4-{[(E)-AMINO(IMINO)METHYL]AMINO} BUTYLBORONIC ACID T - 384
1r64_A_3841r64   A     CACALCIUM ION T - 384
1r64_A_3841r64   A     BOR(1R)-1-AMINO-4-{[(E)-AMINO(IMINO)METHYL]AMINO} BUTYLBORONIC ACID S - 385
1r64_A_3841r64   A     CACALCIUM ION S - 385
1r64_A_3841r64   A     BOR(1R)-1-AMINO-4-{[(E)-AMINO(IMINO)METHYL]AMINO} BUTYLBORONIC ACID A - 386
1r64_A_3841r64   A     NAGN-ACETYL-D-GLUCOSAMINE E - 400
1r64_A_3841r64   A     NAGN-ACETYL-D-GLUCOSAMINE A - 401
1r64_A_3841r64   A     NAGN-ACETYL-D-GLUCOSAMINE N - 402
1r64_A_3841r64   A     NAGN-ACETYL-D-GLUCOSAMINE P - 403
1r64_A_3841r64   A     NAGN-ACETYL-D-GLUCOSAMINE N - 404
1r64_A_3841r64   A     NAGN-ACETYL-D-GLUCOSAMINE L - 405
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1gqi_A_4591gqi   A AC4EDO BINDING SITE FOR CHAIN AR - 468
1gqi_A_4591gqi   A AC2EDO BINDING SITE FOR CHAIN AW - 471
1gqi_A_4591gqi   A AC4EDO BINDING SITE FOR CHAIN AI - 475

Clusters included in this Subclass
CLUSTER: HH.4.17
CLUSTER: HH.5.4
CLUSTER: HH.6.1
CLUSTER: HH.6.99
CLUSTER: HH.7.50
CLUSTER: HH.7.85
CLUSTER: HH.8.17