ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 8.10.1

Subclass Accession number: 2531
Subclass: 8.10.1

Type: HH alpha-alpha
DB: ArchDB40

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 3.2 (>75 %)  3.2.1 (>75 %)  3.2.1.17 3.4 (>75 %)  3.4.22 (>75 %)  3.4.22.40
GO : GO:0003796 (>75 %)  GO:0004175 (>75 %)  GO:0004197 (>75 %)  GO:0004553 (>75 %)  GO:0005509 (>50 %)  GO:0005509 (>75 %)  GO:0008233 (>75 %)  GO:0008234 (>75 %)  GO:0016798 (>75 %)
SCOP : 47472 (>75 %)  47473 (>75 %)  53954 (>75 %)  53955 (>75 %)  53960 (>75 %)  54000 (>75 %)  54001 (>75 %)  54002 (>75 %)  63550 (>75 %)

Number of loops: 3

Average sequence ID (%) : 21.9 +/- 25.5
Average RMSD (Å) : 1.167 +/- 0.473

Consensus geometry

d (Å): 19

delta (°): 135-180

theta (°): 90-135

rho (°): 0-45

Consensus Sequence:	XhcXXXXphSpX
(φψ)-conformation:	aalbabbbppaa

Pattern:	[CW]	[ILW]	[AF]	x	[ACS]	[ALT]	x	x	x	x	[EL]	[CNP]	x	[LMW]	x	[EKL]	[AL]	[GN]	[HIL]	[EKP]	[EL]	[FT]	[EN]	[FL]	[S]	[EQ]	[AQS]	[MY]	[L]	[FV]	x	[CWY]
Conservation:	2.333	-0.330	0.032	-0.820	0.062	-0.722	-0.390	-1.507	-0.722	-0.711	-0.893	-1.017	-1.311	0.160	-1.115	-1.017	-0.187	1.155	-0.820	-0.134	-0.711	0.171	0.834	0.546	1.925	1.540	-0.330	0.915	1.925	0.455	0.032	0.650

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1me4_A_25	1me4	A	25	56	CWAFSAIGNVECQWFLAGHPLTNLSEQMLVSC	HHHHHHHHHHHHHHHHTTS----B-HHHHHHH	aaaaaaaaaaaaaaaaavbxxbxbxaaaaaaa
2cb5_A_73	2cb5	A	74	105	WIFSCLNVMRLPFMKKLNIEEFEFSQSYLFFW	HHHHHHHHHHHHHHHHTT-S---B-HHHHHHH	aaaaaaaaaaaaaaaaalbabbbxxaaaaaaa
3gcb_*_73	3gcb	-	74	105	WLFAATNQLRLNVLSELNLKEFELSQAYLFFY	HHHHHHHHHHHHHHHHTT-SS--B-HHHHHHH	aaaaaaaaaaaaaaaaalbabbbxxaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1me4_A_25	1me4	A	T10[1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL -ETHYL]-CARBAMIC ACID BENZYL ESTER	C - 25
1me4_A_25	1me4	A	T10[1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL -ETHYL]-CARBAMIC ACID BENZYL ESTER	W - 26
3gcb_*_73	3gcb	*	GOLGLYCEROL	Q - 81
3gcb_*_73	3gcb	*	GOLGLYCEROL	L - 82
3gcb_*_73	3gcb	*	GOLGLYCEROL	N - 85

PDB Site Annotated loops in this subclass

Loop	PDB	Chain	Site	Residue
3gcb_*_73	3gcb	*	A73NUCLEOPHILIC CYSTEINE MUTATED TO ALANINE.	A - 73

Clusters included in this Subclass