ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 5.12.1

Subclass Accession number: 4009
Subclass: 5.12.1

Type: AR beta-beta link
DB: ArchDB95

Image coordinates:

Consensus coordinates:

Number of loops: 6

Average sequence ID (%) : 29.8 +/- 33.2
Average RMSD (Å) : 0.883 +/- 0.376

Consensus geometry

d (Å): 9

delta (°): 90-135

theta (°): 135-180

rho (°): 180-225

Consensus Sequence:	hhhXPXXhh
(φψ)-conformation:	bbpbabpbb

Pattern:	[iy]	[GMTV]	[tvy]	[GMVW]	x	[VY]	[AGQ]	[ip]	x	[AP]	x	[ANTV]	[IPY]	x	x
Conservation:	-0.408	-0.722	-0.712	-0.707	-0.648	1.401	0.564	0.130	-0.475	2.808	-0.345	-0.373	-0.463	-0.051	-1.000

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1bdq_A_69	1bdq	A	72	85	IGTVLVGPTPINII.	EEEEEE---SSEEE.	bbxbbxbxbabxbb.
1c6y_A_69	1c6y	A	72	85	IGTVLVGPTPTNII.	EEEEEE-S-SS-EE.	bexbxbbxbabxbb.
1fmb_*_74	1fmb	-	77	90	KTRMLVADIPVTIL.	EEEEEEES-SS-EE.	bbbbxbbxbabxbx.
1fyh_B_28	1fyh	B	28	42	IVYWEYQIMPQVPVF	EEEEE----SS--EE	bxbbbbxxbabxxbb
1hvc_*_69	1hvc	-	72	85	IGTVLVGPTPVNII.	EEEEEEE--SS-EE.	bbxbxbbxxabxbx.
1kmt_A_137	1kmt	A	144	158	YMVGSYGPRAAAYEF	EEEEEE---SS-EEE	bxaebbxxbaxpxbb

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1bdq_A_69	1bdq	A	IM1(2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE	T - 80
1bdq_A_69	1bdq	A	IM1(2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE	P - 81
1bdq_A_69	1bdq	A	IM1(2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE	I - 82
1bdq_A_69	1bdq	A	IM1(2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE	I - 84
1c6y_A_69	1c6y	A	MK1N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S) -HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE	L - 76
1c6y_A_69	1c6y	A	MK1N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S) -HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE	T - 80
1c6y_A_69	1c6y	A	MK1N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S) -HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE	P - 81
1c6y_A_69	1c6y	A	MK1N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S) -HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE	T - 82
1c6y_A_69	1c6y	A	MK1N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S) -HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE	I - 84
1fmb_*_74	1fmb	*	HYB[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL	L - 81
1fmb_*_74	1fmb	*	HYB[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL	I - 85
1fmb_*_74	1fmb	*	HYB[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL	P - 86
1fmb_*_74	1fmb	*	HYB[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL	V - 87
1fmb_*_74	1fmb	*	HYB[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL	I - 89
1hvc_*_69	1hvc	*	A79N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE	L - 76
1hvc_*_69	1hvc	*	A79N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE	T - 80
1hvc_*_69	1hvc	*	A79N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE	P - 81
1hvc_*_69	1hvc	*	A79N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE	V - 82
1hvc_*_69	1hvc	*	A79N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE	I - 84

Clusters included in this Subclass