ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 6.3.1

Subclass Accession number: 45
Subclass: 6.3.1
Type: EH beta-alpha
DB: ArchDB-KI

Number of loops: 7

Average sequence ID (%) : 38.7 +/- 4.3
Average RMSD (Å) : 0.55 +/- 0.19

Consensus geometry

d (Å): 15

delta (°): 45-90

theta (°): 0-45

rho (°): 90-135

Consensus Sequence:	hEhhXXGphX
(φψ)-conformation:	bppbaaepaa

Pattern:	[FLY]	[ILMV]	[IV]	{FMV}	[DE]	[LY]	[AMV]	{AEK}	{HKN}	[G]	[DENS]	[LM]	x	[DES]	{FY}
Conservation:	0.390	-0.126	0.661	-0.993	0.925	0.099	-0.429	-0.958	-1.010	2.328	-0.431	0.516	-1.629	-0.253	0.911

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1apm_E_115	1apm	E	117	131	YMVMEYVAGGEMFSH	EEEEE--TT-BHHHH	bbbbxxbaaexaaaa
1ir3_A_1073	1ir3	A	1073	1087	LVVMELMAHGDLKSY	EEEEE--TT-BHHHH	bbxbxxbaaexaaaa
1irk_*_1073	1irk	-	1073	1087	LVVMELMAHGDLKSY	EEEEE--TT-BHHHH	bbxbxxxaaexaaaa
1phk_*_98	1phk	-	100	114	FLVFDLMKKGELFDY	EEEEE--TT-BHHHH	bbbbxxxaaexaaaa
1ydr_E_115	1ydr	E	117	131	YMVMEYVAGGEMFSH	EEEEE--TT-BHHHH	bbbbxxbaaexaaaa
2fgi_A_558	2fgi	A	558	572	YVIVEYASKGNLREY	EEEEE--TT-BHHHH	bbxbpbbaaexaaaa
3lck_*_313	3lck	-	313	327	YIITEYMENGSLVDF	EEEEE--TT-BHHHH	bbbbpxbaaeEaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1phk_*_98	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	F - 103
1phk_*_98	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	D - 104
1phk_*_98	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	L - 105
1phk_*_98	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	M - 106
1phk_*_98	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	K - 107
1phk_*_98	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	G - 109
1phk_*_98	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	E - 110
1phk_*_98	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	D - 113
1ydr_E_115	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	M - 120
1ydr_E_115	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	E - 121
1ydr_E_115	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	Y - 122
1ydr_E_115	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	V - 123
1ydr_E_115	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	A - 124
1ydr_E_115	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	E - 127

Bibliographic annotations

Loop	PDB	Chain	Annotation	Residue
1apm_E_115	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	M - 120
1apm_E_115	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	E - 121
1apm_E_115	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	Y - 122
1apm_E_115	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	V - 123
1apm_E_115	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	RIBOSE BINDING RESIDUE	E - 127
1ir3_A_1073	1ir3 RefS.R.HUBBARD. CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. v.16;5572,1997	A	ADENINE BINDING RESIDUE	E - 1077
1ir3_A_1073	1ir3 RefS.R.HUBBARD. CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. v.16;5572,1997	A	ADENINE BINDING RESIDUE	M - 1079
1ir3_A_1073	1ir3 RefS.R.HUBBARD. CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. v.16;5572,1997	A	RIBOSE BINDING RESIDUE	D - 1083
2fgi_A_558	2fgi RefM.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,J.SCHLESSINGER,S.R.HUBBARD. CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITOR BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN EMBO J. v.17;5896,1998	A	INHIBITOR BINDING RESIDUE	V - 559
2fgi_A_558	2fgi RefM.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,J.SCHLESSINGER,S.R.HUBBARD. CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITOR BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN EMBO J. v.17;5896,1998	A	INHIBITOR BINDING RESIDUE	V - 561
2fgi_A_558	2fgi RefM.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,J.SCHLESSINGER,S.R.HUBBARD. CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITOR BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN EMBO J. v.17;5896,1998	A	ADENINE BINDING RESIDUE	E - 562
2fgi_A_558	2fgi RefM.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,J.SCHLESSINGER,S.R.HUBBARD. CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITOR BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN EMBO J. v.17;5896,1998	A	ADENINE BINDING RESIDUE	Y - 563
2fgi_A_558	2fgi RefM.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,J.SCHLESSINGER,S.R.HUBBARD. CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITOR BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN EMBO J. v.17;5896,1998	A	ADENINE BINDING RESIDUE	A - 564

Clusters included in this Subclass

CLUSTER: EH.5.2

CLUSTER: EH.5.8

CLUSTER: EH.5.9