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Information on SUBCLASS 2.1.2
Subclass Accession number: 4502
Subclass: 2.1.2 PSSM
Type: HH alpha-alpha
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 75

Average sequence ID (%) : 11.7 +/- 14.1
Average RMSD (Å) : 0.625 +/- 0.225

Consensus geometry
d (Å): 11 delta (°): 0-45 theta (°): 90-135 rho (°): 225-270
Consensus Sequence: XpXXXX
(φψ)-conformation: aappaa
Pattern: x[adegknqrst]xxxxx[adegnpqst]x[adegknqrst]xx
Conservation:-1.630-0.162-0.313-0.390-0.6080.1841.3182.294-0.7590.2330.023-0.190
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a4s_A_571a4s   A7182YLKWSKMAGIERHHHHTTS-HHHHaaaaaaxxaaaa
1a8q_*_1741a8q   -181192WYMAMAQTIEGGHHHHTTS-HHHHaaaaaaxxaaaa
1aa7_A_1091aa7   A113124KEISLSYSAGALHHHHTTS-HHHHaaaaaabxaaaa
1aln_*_61aln   -617QTAFAQLADNLQHHHHHTS-HHHHaaaaaaxxaaaa
1axn_*_391axn   -4354ISILTERSNAQRHHHHTTS-HHHHaaaaaabxaaaa
1b3u_A_1011b3u   A112123RAISHEHSPSDLHHHHTTS-HHHHaaaaaaxxaaaa
1b3u_A_2231b3u   A228239VNIAQLLPQEDLHHHHHHS-HHHHaaaaaabxaaaa
1cki_A_2301cki   A234245SEKKMSTPIEVLHHHHHHS-HHHHaaaaaaxwaaaa
1csn_*_2261csn   -234245GEKKQSTPLRELHHHHHHS-HHHHaaaaaaxxaaaa
1d2t_A_591d2t   A6475AAEDANLSSGGVHHHHHH--HHHHaaaaaapxaaaa
1dc1_A_801dc1   A8091DKAKKFLTEDDKHHHHTT--HHHHaaaaaaxxaaaa
1dm5_A_1051dm5   A109120IDILCTQSNAQIHHHHSS--HHHHaaaaaaxxaaaa
1eex_A_1101eex   A114125VEVVSHMNVVEMHHHHTT--HHHHaaaaaabxaaaa
1eex_A_981eex   A102113VPLTTAMTPAKIHHHHTTS-HHHHaaaaaaxxaaaa
1eex_G_991eex   G108119AAELTAVPDDRIHHHHTTS-HHHHaaaaaaxxaaaa
1ef8_A_1841ef8   A195206AHHISEKAPLAIHHHHTTS-HHHHaaaaaaxxaaaa
1ey3_A_2181ey3   A226237AEKIANNSKIIVHHHHHTS-HHHHaaaaaaxpaaaa
1f76_A_31f76   A718RKALFQLDPERAHHHHTTS-HHHHaaaaaaxxaaaa
1f7t_A_321f7t   A3546LDQYYELSEKRKHHHHTTS-HHHHaaaaaaxxaaaa
1fwx_A_611fwx   A6576RIHERTMSERTKHHHHTT--HHHHaaaaaapxaaaa
1fx2_A_10671fx2   A10671078HAAYMSLSAEDRHHHHHTS-HHHHaaaaaaxxaaaa
1g5n_A_331g5n   A3748LNLLTARSNAQRHHHHTTS-HHHHaaaaaabxaaaa
1g5n_A_731g5n   A7889LIVALMKPSRLYHHHHHHS-HHHHaaaaaaxpaaaa
1gp6_A_891gp6   A99110GEEFFSLSVEEKHHHHHTS-HHHHaaaaaaxxaaaa
1h1o_A_1591h1o   A162173NQIAKNITVAQMHHHHTT--HHHHaaaaaaxxaaaa
1h1o_A_651h1o   A6576WPVAQALDSAKIHHHHHT--HHHHaaaaaabbaaaa
1h54_A_2711h54   A282293SDKVAQSSYEDLHHHHTTS-HHHHaaaaaabxaaaa
1hq1_A_251hq1   A2940EAIINSMTMKERHHHHHTS-HHHHaaaaaaxxaaaa
1hyp_*_251hyp   -2940CALIGGLGDIEAHHHHHTS-HHHHaaaaaaxxaaaa
1i2t_A_10291i2t   A10331044TGMLLELSPAQLHHHHTTS-HHHHaaaaaaxxaaaa
1i4a_A_331i4a   A3748INVLAYRSTAQRHHHHTTS-HHHHaaaaaabxaaaa
1i58_A_4711i58   A471482ESKAATLSDQEIHHHHTT--HHHHaaaaaaxxaaaa
1iq8_A_2891iq8   A289300PQELREMPKEERHHHHTTS-HHHHaaaaaaxxaaaa
1iwp_A_1111iwp   A115126VEVMAQMNVVEMHHHHHT--HHHHaaaaaabxaaaa
1iwp_A_741iwp   A7788TEQAMRLEAVEIHHHHTTS-HHHHaaaaaaxxaaaa
1iwp_A_991iwp   A103114IAITTAITPAKAHHHHTTS-HHHHaaaaaabbaaaa
1j0h_A_3941j0h   A402413MHVLHSYPNNVNHHHHHTS-HHHHaaaaaabxaaaa
1j3n_A_621j3n   A6273RKELRRLDRFVQHHHHTTS-HHHHaaaaaabxaaaa
1j7n_A_541j7n   A6071EKLLEKVPSDVLHHHHHTS-HHHHaaaaaaxpaaaa
1j98_A_1341j98   A141152MRFWLSQDKEELHHHHHTS-HHHHaaaaaaxxaaaa
1kek_A_5191kek   A520531EDMDKHLPSGIKHHHHHHS-HHHHaaaaaaxpaaaa
1ko7_A_551ko7   A5869LSFYNLLPDEERHHHHHHS-HHHHaaaaaaxxaaaa
1m4z_A_1891m4z   A193204KAYIKKVEPREAHHHHTTS-HHHHaaaaaaxxaaaa
1m70_A_1661m70   A168179RGVAAKLSNKDIHHHHTT--HHHHaaaaaaxxaaaa
1m98_A_201m98   A2536IARFKQLSAEDQHHHHTTS-HHHHaaaaaaxpaaaa
1n00_A_361n00   A4051IDILGHRNAEQRHHHHTT--HHHHaaaaaabxaaaa
1n3l_A_1271n3l   A134145YRLSSVVTQHDSHHHHTTS-HHHHaaaaaaxxaaaa
1n5m_A_2661n5m   A270281IACLRTRPAQDLHHHHTTS-HHHHaaaaaaxwaaaa
1n69_A_431n69   A5970IQMMMHMQPKEIHHHHTTS-HHHHaaaaaabxaaaa
1nni_1_801nni   18394KNALDFLSSEQFHHHHHH--HHHHaaaaaaxbaaaa
1od5_A_4551od5   A456467KDVFRAIPSEVLHHHHHHS-HHHHaaaaaaxpaaaa
1omr_A_1191omr   A127138TAIFKMISPEDTHHHHTTS-HHHHaaaaaaxxaaaa
1oqu_C_521oqu   C5263IQSWNKMTPQEQHHHHTTS-HHHHaaaaaaxxaaaa
1oyz_A_141oyz   A1728YNQCKKLNDDELHHHHHTS-HHHHaaaaaaxxaaaa
1p0i_A_2571p0i   A261272IKCLRNKDPQEIHHHHTTS-HHHHaaaaaaxxaaaa
1p1m_A_801p1m   A8192LPIEDRLTEKMAHHHHTT--HHHHaaaaaaxxaaaa
1pp7_U_61pp7   U819ASFTSRLPPEIVHHHHTTS-HHHHaaaaaabwaaaa
1ppr_M_2441ppr   M255266GRVIASVPKSTVHHHHTTS-HHHHaaaaaabxaaaa
1ppr_M_821ppr   M93104GRVIASVPENMVHHHHHTS-HHHHaaaaaabxaaaa
1px5_A_1901px5   A194205RDFLRNRPTKLKHHHHHSS-HHHHaaaaaabwaaaa
1q0s_A_531q0s   A5970YKRLINVSWDDVHHHHTT--HHHHaaaaaabbaaaa
1q52_A_2381q52   A247258AAEINAKSPQAQHHHHTS-HHHHHaaaaaabxaaaa
1qc7_A_2461qc7   A250261QLVLREVDTRDLHHHHTSS-HHHHaaaaaabxaaaa
1qc7_A_2701qc7   A274285EKIFKNMSKRAAHHHHTTS-HHHHaaaaaabxaaaa
1qc7_B_2461qc7   B250261QLVLREVDTRDLHHHHHHS-HHHHaaaaaaxxaaaa
1qc7_B_2701qc7   B274285EKIFKNMSKRAAHHHHTTS-TTHHaaaaaabpaaaa
1qh4_A_61qh4   A819NLLKMKYSVDDEHHHHHHS-HHHHaaaaaaxxaaaa
1qr0_A_141qr0   A1829ERFMTFISPEKRHHHHTTS-HHHHaaaaaaxxaaaa
1qyi_A_821qyi   A90101IDILKKLSHDEIHHHHTTS-HHHHaaaaaaxxaaaa
1s3e_A_3471s3e   A349360ARKLARLTKEERHHHHTTS-HHHHaaaaaaxxaaaa
1sur_*_131sur   -2435NAELEKLDAEGRHHHHTTS-HHHHaaaaaaxxaaaa
1sur_*_51sur   -516LNALNELPKVDRHHHHHTS-HHHHaaaaaaxxaaaa
1tki_A_2411tki   A241252EEAFKEISIEAMHHHHTTS-HHHHaaaaaaxxaaaa
1tn4_*_21tn4   -516AEARSYLSEEMIHHHHHTS-HHHHaaaaaabxaaaa
1utg_*_321utg   -4253KKVLDSLPQTTRHHHHTTS-HHHHaaaaaaxwaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE K - 81
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE K - 84
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE F - 85
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE L - 86
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE D - 89
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE D - 90
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE K - 91
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE E - 93
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE S - 94
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE N - 97
1f76_A_31f76   A     MSESELENOMETHIONINE Y - 3
1f76_A_31f76   A     OROOROTIC ACID Y - 3
1f76_A_31f76   A     MSESELENOMETHIONINE P - 4
1f76_A_31f76   A     MSESELENOMETHIONINE F - 5
1f76_A_31f76   A     MSESELENOMETHIONINE V - 6
1f76_A_31f76   A     OROOROTIC ACID V - 6
1f76_A_31f76   A     MSESELENOMETHIONINE E - 16
1f76_A_31f76   A     MSESELENOMETHIONINE H - 19
1f76_A_31f76   A     MSESELENOMETHIONINE L - 26
1f7t_A_321f7t   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE S - 61
1f7t_A_321f7t   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE K - 62
1f7t_A_321f7t   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE A - 63
1g5n_A_331g5n   A     CACALCIUM ION E - 33
1g5n_A_731g5n   A     CACALCIUM ION G - 73
1g5n_A_731g5n   A     SGNN,O6-DISULFO-GLUCOSAMINE E - 76
1g5n_A_731g5n   A     CACALCIUM ION E - 76
1g5n_A_731g5n   A     CACALCIUM ION A - 97
1g5n_A_731g5n   A     CACALCIUM ION L - 98
1h1o_A_651h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE V - 67
1h1o_A_651h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE A - 68
1h1o_A_651h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 71
1h1o_A_651h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 79
1h1o_A_651h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE A - 80
1h1o_A_651h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 83
1h1o_A_651h1o   A     ZNZINC ION N - 84
1h1o_A_1591h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE T - 159
1h1o_A_1591h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 160
1h1o_A_1591h1o   A     GOLGLYCEROL L - 160
1h1o_A_1591h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE M - 161
1h1o_A_1591h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE Q - 163
1h1o_A_1591h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE I - 164
1h1o_A_1591h1o   A     ZNZINC ION K - 166
1h1o_A_1591h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE I - 168
1h1o_A_1591h1o   A     ZNZINC ION I - 168
1h1o_A_1591h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE V - 176
1h1o_A_1591h1o   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 180
1h1o_A_1591h1o   A     ZNZINC ION S - 181
1iq8_A_2891iq8   A     ZNZINC ION H - 307
1iq8_A_2891iq8   A     ZNZINC ION N - 308
1iq8_A_2891iq8   A     ZNZINC ION W - 310
1iq8_A_2891iq8   A     ZNZINC ION V - 311
1ko7_A_551ko7   A     PO4PHOSPHATE ION T - 55
1ko7_A_551ko7   A     PO4PHOSPHATE ION T - 56
1ko7_A_551ko7   A     PO4PHOSPHATE ION E - 57
1m70_A_1661m70   A     HECHEME C I - 166
1m70_A_1661m70   A     HECHEME C M - 167
1m70_A_1661m70   A     HECHEME C V - 170
1m70_A_1661m70   A     HECHEME C L - 174
1m70_A_1661m70   A     HECHEME C L - 182
1m70_A_1661m70   A     CRYPROPANE-1,2,3-TRIOL Y - 185
1m70_A_1661m70   A     HECHEME C I - 186
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE Q - 36
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE L - 37
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE A - 38
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE I - 40
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE W - 41
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE Y - 44
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE M - 43
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE A - 44
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE I - 46
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE C - 47
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE Y - 50
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE I - 51
1nni_1_801nni   1     MSESELENOMETHIONINE G - 80
1nni_1_801nni   1     MSESELENOMETHIONINE L - 82
1nni_1_801nni   1     MSESELENOMETHIONINE K - 83
1nni_1_801nni   1     MSESELENOMETHIONINE L - 86
1nni_1_801nni   1     MSESELENOMETHIONINE F - 94
1omr_A_1191omr   A     CACALCIUM ION E - 121
1oqu_C_521oqu   C     FEFE (III) ION D - 77
1oqu_C_521oqu   C     FEFE (III) ION Q - 80
1p1m_A_801p1m   A     METMETHIONINE L - 81
1p1m_A_801p1m   A     METMETHIONINE E - 84
1pp7_U_61pp7   U     ZNZINC ION E - 7
1ppr_M_821ppr   M     CLACHLOROPHYLL A W - 85
1ppr_M_821ppr   M     PIDPERIDININ W - 85
1ppr_M_821ppr   M     PIDPERIDININ V - 88
1ppr_M_821ppr   M     CLACHLOROPHYLL A N - 89
1ppr_M_821ppr   M     PIDPERIDININ N - 89
1ppr_M_821ppr   M     CLACHLOROPHYLL A L - 92
1ppr_M_821ppr   M     PIDPERIDININ L - 92
1ppr_M_821ppr   M     PIDPERIDININ G - 93
1ppr_M_821ppr   M     CLACHLOROPHYLL A V - 95
1ppr_M_821ppr   M     PIDPERIDININ V - 95
1ppr_M_821ppr   M     CLACHLOROPHYLL A I - 96
1ppr_M_821ppr   M     PIDPERIDININ I - 96
1ppr_M_821ppr   M     PIDPERIDININ P - 100
1ppr_M_821ppr   M     PIDPERIDININ E - 101
1ppr_M_821ppr   M     PIDPERIDININ V - 104
1ppr_M_821ppr   M     PIDPERIDININ M - 105
1ppr_M_821ppr   M     PIDPERIDININ V - 107
1ppr_M_821ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) V - 107
1ppr_M_821ppr   M     CLACHLOROPHYLL A Y - 108
1ppr_M_821ppr   M     PIDPERIDININ Y - 108
1ppr_M_821ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) Y - 108
1ppr_M_821ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) V - 111
1ppr_M_821ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) S - 112
1ppr_M_821ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) K - 113
1ppr_M_821ppr   M     PIDPERIDININ I - 114
1ppr_M_821ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) I - 114
1ppr_M_2441ppr   M     CLACHLOROPHYLL A Y - 247
1ppr_M_2441ppr   M     PIDPERIDININ Y - 247
1ppr_M_2441ppr   M     PIDPERIDININ V - 250
1ppr_M_2441ppr   M     CLACHLOROPHYLL A N - 251
1ppr_M_2441ppr   M     PIDPERIDININ N - 251
1ppr_M_2441ppr   M     CLACHLOROPHYLL A L - 254
1ppr_M_2441ppr   M     PIDPERIDININ L - 254
1ppr_M_2441ppr   M     PIDPERIDININ G - 255
1ppr_M_2441ppr   M     CLACHLOROPHYLL A V - 257
1ppr_M_2441ppr   M     PIDPERIDININ V - 257
1ppr_M_2441ppr   M     CLACHLOROPHYLL A I - 258
1ppr_M_2441ppr   M     PIDPERIDININ I - 258
1ppr_M_2441ppr   M     PIDPERIDININ P - 262
1ppr_M_2441ppr   M     PIDPERIDININ K - 263
1ppr_M_2441ppr   M     PIDPERIDININ V - 266
1ppr_M_2441ppr   M     PIDPERIDININ M - 267
1ppr_M_2441ppr   M     PIDPERIDININ V - 269
1ppr_M_2441ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) V - 269
1ppr_M_2441ppr   M     CLACHLOROPHYLL A Y - 270
1ppr_M_2441ppr   M     PIDPERIDININ Y - 270
1ppr_M_2441ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) Y - 270
1ppr_M_2441ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) M - 273
1ppr_M_2441ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) A - 274
1q0s_A_531q0s   A     SAHS-ADENOSYL-L-HOMOCYSTEINE I - 55
1qr0_A_141qr0   A     COACOENZYME A K - 28
1qr0_A_141qr0   A     COACOENZYME A K - 31
1qyi_A_821qyi   A     MSESELENOMETHIONINE F - 82
1qyi_A_821qyi   A     MSESELENOMETHIONINE I - 83
1qyi_A_821qyi   A     MSESELENOMETHIONINE V - 84
1qyi_A_821qyi   A     MSESELENOMETHIONINE F - 85
1qyi_A_821qyi   A     MSESELENOMETHIONINE L - 93
1qyi_A_821qyi   A     MSESELENOMETHIONINE E - 100
1qyi_A_821qyi   A     MSESELENOMETHIONINE I - 101
1qyi_A_821qyi   A     MSESELENOMETHIONINE E - 102
1qyi_A_821qyi   A     MSESELENOMETHIONINE A - 103
1tn4_*_21tn4   *     CACALCIUM ION F - 26
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1h1o_A_651h1o   A ZN2ZN BINDING SITE FOR CHAIN AN - 84
1h1o_A_1591h1o   A S1BSO4 BINDING SITE FOR CHAIN AA - 171
1h1o_A_1591h1o   A S1BSO4 BINDING SITE FOR CHAIN AD - 175

Clusters included in this Subclass
CLUSTER: HH.2.36
CLUSTER: HH.3.14
CLUSTER: HH.4.350
CLUSTER: HH.4.6
CLUSTER: HH.5.4