ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 7.2.1

Subclass Accession number: 49
Subclass: 7.2.1
Type: EH beta-alpha
DB: ArchDB-KI

Number of loops: 4

Average sequence ID (%) : 37.5 +/- 0.5
Average RMSD (Å) : 0.75 +/- 0.15

Consensus geometry

d (Å): 17

delta (°): 45-90

theta (°): 45-90

rho (°): 90-135

Consensus Sequence:	VXEYhppGpLh
(φψ)-conformation:	bbppbaaepaa

Pattern:	[WY]	[ILMV]	[IV]	x	[DE]	[Y]	{AMV}	{PS}	{HK}	[G]	[ENS]	[LM]	{FL}	[DES]	{FY}	[L]
Conservation:	1.166	-0.338	0.307	-1.076	0.429	2.069	-1.301	-0.854	-1.010	1.556	-0.558	0.131	-1.065	-0.310	0.326	0.529

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1b6c_B_276	1b6c	B	277	292	WLVSDYHEHGSLFDYL	EEEE---TT-BHHHHH	bbbbxbbaaexaaaaa
1cdk_A_115	1cdk	A	117	132	YMVMEYVPGGEMFSHL	EEEE---TT-BHHHHH	bbbbxxbaaexaaaaa
1fgk_A_558	1fgk	A	558	573	YVIVEYASKGNLREYL	EEEE---TT-BHHHHH	bbxbxxbaaexaaaaa
2src_*_335	2src	-	335	350	YIVTEYMSKGSLLDFL	EEEE---TT-BHHHHH	bbxbxxbaaexaaaaa

Bibliographic annotations

Loop	PDB	Chain	Annotation	Residue
1cdk_A_115	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	ADENINE BINDING RESIDUE	E - 121
1cdk_A_115	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	ADENINE BINDING RESIDUE	V - 123
1cdk_A_115	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	ATP BINDING RESIDUE	E - 127
1cdk_A_115	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	PKI PEPTIDE BINDING RESIDUE	E - 127
1fgk_A_558	1fgk RefM.MOHAMMADI, J.SCHLESSINGER, S.R.HUBBARD. STRUCTURE OF THE FGF RECEPTOR TYROSINE KINASE DOMAIN REVEALS A NOVEL AUTOINHIBITORY MECHANISM CELL v.86;577,1996	A	ATP BINDING RESIDUE	A - 564
1fgk_A_558	1fgk RefM.MOHAMMADI, J.SCHLESSINGER, S.R.HUBBARD. STRUCTURE OF THE FGF RECEPTOR TYROSINE KINASE DOMAIN REVEALS A NOVEL AUTOINHIBITORY MECHANISM CELL v.86;577,1996	A	ATP BINDING RESIDUE	A - 564

Clusters included in this Subclass

CLUSTER: EH.6.1