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Information on SUBCLASS 6.5.1
Subclass Accession number: 4945
Subclass: 6.5.1 PSSM
Type: HH alpha-alpha
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 11

Average sequence ID (%) : 38.9 +/- 27.7
Average RMSD (Å) : 0.600 +/- 0.141

Consensus geometry
d (Å): 15 delta (°): 90-135 theta (°): 135-180 rho (°): 315-360
Consensus Sequence: pXchhGcpXX
(φψ)-conformation: aalaaeabaa
Pattern: [ST]x[ACT][I][AILV][NR][HY][ILM][AGS][DKRST][EKST][FHLY][dgn][ILM][cilmy][G][EGKT][CDNST]x[ekl][EN][aekr][AFY]x[AIMV][DES][EKM][ILVY]x[deg][AGQT][AILV]x[D][IL][ehrt][cehnqy][gkm][FIVY]
Conservation:0.764-0.7950.2051.425-0.2220.9301.9350.5680.182-0.595-0.0510.130-0.0790.634-1.0702.687-0.647-0.564-1.027-0.6251.023-0.710-0.314-1.1500.1580.635-0.0170.027-1.195-0.850-0.510-0.030-0.9372.6870.804-1.186-1.189-0.995-0.037
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1aqw_A_651aqw   A65103SNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYHHHHHHHHHHHHT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaavaaeabaaaaaaaaaaaaaaaaaaaaa
1dug_A_671dug   A67105SMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVHHHHHHHHHHHTT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaalaaeabaaaaaaaaaaaaaaaaaaaaa
1ev9_A_681ev9   A68106TRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIHHHHHHHHHHHTT-S-SSTTHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaalaaeabaaaaaaaaaaaaaaaaaaaaa
1glq_A_651glq   A65103SNAILRHLGRSLGLYGKNQREAAQMDMVNDGVEDLRGKYHHHHHHHHHHHHT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaavaaeabaaaaaaaaaaaaaaaaaaaaa
1k3y_A_681k3y   A68106TRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMIHHHHHHHHHHHTT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaalaaeabaaaaaaaaaaaaaaaaaaaaa
1ml6_A_671ml6   A67105TRAILNYIATKYDLYGKDMKERALIDMYTEGILDLTEMIHHHHHHHHHHHTT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaalaaeabaaaaaaaaaaaaaaaaaaaaa
1oe8_A_711oe8   A71109SLAIARYMAKKHHMMGGTEEEYYNVEKLIGQAEDLEHEYHHHHHHHHHHHTT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaalaaeabaaaaaaaaaaaaaaaaaaaaa
1okt_A_721okt   A72110SQAIVRYLSKKYNICGESELNEFYADMIFCGVQDIHYKFHHHHHHHHHHHTT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaalaaeabaaaaaaaaaaaaaaaaaaaaa
2fhe_A_672fhe   A67105SLAILRYIADKHGMIGTTSEERARVSMIEGAAVDLRQGIHHHHHHHHHHHTT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaavaaeabaaaaaaaaaaaaaaaaaaaaa
2gsq_*_632gsq   -63101SMCIARHLAREFGLDGKTSLEKYRVDEITETLQDIFNDVHHHHHHHHHHHTT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaavaaeaxaaaaaaaaaaaaaaaaaaaaa
2gsr_A_632gsr   A63101SNAILRHLGRSFGLYGKDQKEAALVDMVNDGVEDLRCKYHHHHHHHHHHHHT-S-SSHHHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaavaaeabaaaaaaaaaaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1aqw_A_651aqw   A     ILGGLUTAMYL GROUP S - 65
1aqw_A_651aqw   A     ILGGLUTAMYL GROUP N - 66
1aqw_A_651aqw   A     ILGGLUTAMYL GROUP D - 94
1aqw_A_651aqw   A     ILGGLUTAMYL GROUP E - 97
1aqw_A_651aqw   A     ILGGLUTAMYL GROUP D - 98
1dug_A_671dug   A     GSHGLUTHATHIONE S - 67
1dug_A_671dug   A     GSHGLUTHATHIONE M - 68
1dug_A_671dug   A     GSHGLUTHATHIONE G - 96
1dug_A_671dug   A     GSHGLUTHATHIONE A - 97
1dug_A_671dug   A     GSHGLUTHATHIONE D - 100
1dug_A_671dug   A     GSHGLUTHATHIONE Y - 103
1ev9_A_681ev9   A     GTSGLUTATHIONE SULFONIC ACID T - 68
1ev9_A_681ev9   A     GTSGLUTATHIONE SULFONIC ACID R - 69
1glq_A_651glq   A     GTBS-(P-NITROBENZYL)GLUTATHIONE S - 65
1glq_A_651glq   A     GTBS-(P-NITROBENZYL)GLUTATHIONE N - 66
1glq_A_651glq   A     GTBS-(P-NITROBENZYL)GLUTATHIONE D - 94
1glq_A_651glq   A     GTBS-(P-NITROBENZYL)GLUTATHIONE E - 97
1glq_A_651glq   A     GTBS-(P-NITROBENZYL)GLUTATHIONE D - 98
1glq_A_651glq   A     GTBS-(P-NITROBENZYL)GLUTATHIONE V - 104
1glq_A_651glq   A     GTBS-(P-NITROBENZYL)GLUTATHIONE Y - 108
1k3y_A_681k3y   A     GTXS-HEXYLGLUTATHIONE T - 68
1k3y_A_681k3y   A     GOLGLYCEROL T - 68
1k3y_A_681k3y   A     GTXS-HEXYLGLUTATHIONE R - 69
1k3y_A_681k3y   A     GOLGLYCEROL R - 69
1k3y_A_681k3y   A     GTXS-HEXYLGLUTATHIONE I - 71
1k3y_A_681k3y   A     GOLGLYCEROL L - 72
1k3y_A_681k3y   A     GOLGLYCEROL I - 96
1k3y_A_681k3y   A     GTXS-HEXYLGLUTATHIONE E - 97
1k3y_A_681k3y   A     GOLGLYCEROL E - 97
1k3y_A_681k3y   A     GOLGLYCEROL I - 99
1k3y_A_681k3y   A     GOLGLYCEROL A - 100
1k3y_A_681k3y   A     GTXS-HEXYLGLUTATHIONE D - 101
1k3y_A_681k3y   A     GOLGLYCEROL D - 101
1k3y_A_681k3y   A     GOLGLYCEROL E - 104
1k3y_A_681k3y   A     GTXS-HEXYLGLUTATHIONE L - 107
1k3y_A_681k3y   A     GTXS-HEXYLGLUTATHIONE L - 108
1ml6_A_671ml6   A     GBX2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7, 8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID T - 67
1ml6_A_671ml6   A     GBX2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7, 8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID R - 68
1ml6_A_671ml6   A     IOH2-PROPANOL, ISOPROPANOL K - 83
1ml6_A_671ml6   A     IOH2-PROPANOL, ISOPROPANOL D - 84
1ml6_A_671ml6   A     IOH2-PROPANOL, ISOPROPANOL M - 85
1ml6_A_671ml6   A     IOH2-PROPANOL, ISOPROPANOL K - 86
1ml6_A_671ml6   A     IOH2-PROPANOL, ISOPROPANOL R - 88
1ml6_A_671ml6   A     GBX2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7, 8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID E - 96
1ml6_A_671ml6   A     GBX2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7, 8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID D - 100
1ml6_A_671ml6   A     CSOS-HYDROXYCYSTEINE Q - 107
1ml6_A_671ml6   A     GBX2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7, 8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID Q - 107
1oe8_A_711oe8   A     GSHGLUTHATHIONE S - 71
1oe8_A_711oe8   A     GSHGLUTHATHIONE L - 72
1oe8_A_711oe8   A     GSHGLUTHATHIONE G - 100
1oe8_A_711oe8   A     GSHGLUTHATHIONE Q - 101
1oe8_A_711oe8   A     GSHGLUTHATHIONE D - 104
1okt_A_721okt   A     FMTFORMIC ACID S - 72
1okt_A_721okt   A     FMTFORMIC ACID Q - 73
1okt_A_721okt   A     FMTFORMIC ACID I - 75
2fhe_A_672fhe   A     GGLGAMMA-GLUTAMIC ACID S - 67
2fhe_A_672fhe   A     GGLGAMMA-GLUTAMIC ACID L - 68
2fhe_A_672fhe   A     GGLGAMMA-GLUTAMIC ACID G - 96
2fhe_A_672fhe   A     GGLGAMMA-GLUTAMIC ACID A - 97
2fhe_A_672fhe   A     GGLGAMMA-GLUTAMIC ACID D - 100
2gsq_*_632gsq   *     GBIS-(3-IODOBENZYL)GLUTATHIONE S - 63
2gsq_*_632gsq   *     GBIS-(3-IODOBENZYL)GLUTATHIONE M - 64
2gsq_*_632gsq   *     GBIS-(3-IODOBENZYL)GLUTATHIONE I - 66
2gsq_*_632gsq   *     GBIS-(3-IODOBENZYL)GLUTATHIONE F - 98
2gsq_*_632gsq   *     GBIS-(3-IODOBENZYL)GLUTATHIONE N - 99
2gsq_*_632gsq   *     GBIS-(3-IODOBENZYL)GLUTATHIONE V - 102
2gsq_*_632gsq   *     GBIS-(3-IODOBENZYL)GLUTATHIONE K - 103
2gsq_*_632gsq   *     GBIS-(3-IODOBENZYL)GLUTATHIONE I - 104
2gsr_A_632gsr   A     ILGGLUTAMYL GROUP S - 63
2gsr_A_632gsr   A     ILGGLUTAMYL GROUP N - 64
2gsr_A_632gsr   A     ILGGLUTAMYL GROUP D - 92
2gsr_A_632gsr   A     ILGGLUTAMYL GROUP E - 95
2gsr_A_632gsr   A     ILGGLUTAMYL GROUP D - 96
2gsr_A_632gsr   A     OCSCYSTEINESULFONIC ACID Y - 106
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1oe8_A_711oe8   A AC1GSH BINDING SITE FOR CHAIN AS - 71
1oe8_A_711oe8   A AC2GSH BINDING SITE FOR CHAIN BD - 104
1okt_A_721okt   A AC1FMT BINDING SITE FOR CHAIN AS - 72
1okt_A_721okt   A AC1FMT BINDING SITE FOR CHAIN AQ - 73

Clusters included in this Subclass
CLUSTER: HH.6.38
CLUSTER: HH.8.118
CLUSTER: HH.8.27