ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 12.5.1

Subclass Accession number: 5140
Subclass: 12.5.1

Type: HH alpha-alpha
DB: ArchDB95

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 2.5 (>50 %)  2.5.1 (>50 %)  2.5.1.18
GO : GO:0004364 (>50 %)  GO:0016765 (>50 %)
SCOP : 47615 (>75 %)  47616 (>75 %)  47617 (>75 %)

Number of loops: 3

Average sequence ID (%) : 42.1 +/- 14.2
Average RMSD (Å) : 0.400 +/- 0.000

Consensus geometry

d (Å): 17

delta (°): 90-135

theta (°): 135-180

rho (°): 270-315

Consensus Sequence:	DXXPXpXLhhhXcXhp
(φψ)-conformation:	aabaaalabppplpaa

Pattern:	[GN]	[PV]	[A]	[I]	[LMV]	x	[Y]	[IL]	[A]	[D]	x	x	[P]	[AD]	[RS]	[GNQ]	[L]	[AIL]	[AP]	[AP]	x	[GKN]	[AS]	[IL]	[DES]	[R]	[Y]	[HKR]	x	[IL]	[ES]	[RW]	[L]	[NS]	[FY]	[IL]	[AG]	[ST]
Conservation:	0.061	-0.797	0.590	0.590	-0.375	-0.899	2.326	0.028	0.590	1.748	-1.404	-1.404	2.326	-0.701	-0.617	-0.889	0.590	-0.954	-0.516	-0.221	-1.340	-0.889	-0.215	0.047	-0.504	1.169	2.326	-0.439	-1.340	0.028	-0.336	0.108	0.590	0.143	1.014	0.047	-0.335	-0.143

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1f2e_A_66	1f2e	A	66	103	NPAILLYIADQNPASGLAPAEGSLDRYRLLSRLSFLGS	HHHHHHHHHHT-TTT-SS--TT-HHHHHHHHHHHHHHH	aaaaaaaaaaabaaalabwxpvxaaaaaaaaaaaaaaa
1n2a_A_66	1n2a	A	66	103	GVAIMQYLADSVPDRQLLAPVNSISRYKTIEWLNYIAT	HHHHHHHHHHT-GGG-SS--TT-HHHHHHHHHHHHHHH	aaaaaaaaaaabaaalabxxpvxaaaaaaaaaaaaaaa
1pmt_*_66	1pmt	-	66	103	GVAIVQYLADLKPDRNLIAPPKALERYHQIEWLNFLAS	HHHHHHHHHTT-GGG-SS--TTSHHHHHHHHHHHHHHH	aaaaaaaaaaabaaalabbwxUxaaaaaaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1f2e_A_66	1f2e	A	GTTGLUTATHIONE	N - 66
1f2e_A_66	1f2e	A	GTTGLUTATHIONE	P - 67
1f2e_A_66	1f2e	A	GTTGLUTATHIONE	S - 99
1f2e_A_66	1f2e	A	GTTGLUTATHIONE	F - 100
1f2e_A_66	1f2e	A	GTTGLUTATHIONE	G - 102
1f2e_A_66	1f2e	A	GTTGLUTATHIONE	S - 103
1n2a_A_66	1n2a	A	GTSGLUTATHIONE SULFONIC ACID	G - 66
1n2a_A_66	1n2a	A	GTSGLUTATHIONE SULFONIC ACID	V - 67
1n2a_A_66	1n2a	A	GTSGLUTATHIONE SULFONIC ACID	N - 99
1n2a_A_66	1n2a	A	GTSGLUTATHIONE SULFONIC ACID	Y - 100
1n2a_A_66	1n2a	A	GTSGLUTATHIONE SULFONIC ACID	A - 102
1n2a_A_66	1n2a	A	GTSGLUTATHIONE SULFONIC ACID	T - 103
1n2a_A_66	1n2a	A	GTSGLUTATHIONE SULFONIC ACID	E - 104
1pmt_*_66	1pmt	*	GTTGLUTATHIONE	G - 66
1pmt_*_66	1pmt	*	GTTGLUTATHIONE	V - 67
1pmt_*_66	1pmt	*	GTTGLUTATHIONE	A - 102

Clusters included in this Subclass

CLUSTER: HH.13.31