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Information on SUBCLASS 2.5.2
Subclass Accession number: 5404
Subclass: 2.5.2 PSSM
Type: HE alpha-beta
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 62

Average sequence ID (%) : 18.1 +/- 18.3
Average RMSD (Å) : 0.526 +/- 0.186

Consensus geometry
d (Å): 7 delta (°): 90-135 theta (°): 90-135 rho (°): 135-180
Consensus Sequence: XXGhph
(φψ)-conformation: aagpbb
Pattern: x[acfgilmvwy][adegknqrst][adegknqrs]x[adegknqr][acfgilmvwy][cehknqrsty][acfilmptv]x
Conservation:-1.034-0.116-0.167-0.108-0.6902.671-0.4840.000-0.1570.084
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1b33_N_331b33   N4251RIQKMGGKIVHHHHTT-EEEaaaaavxbxa
1bdb_*_1171bdb   -129138ALVASRGNVIHHHHHT-EEEaaaaalxbbb
1bgx_T_7641bgx   T771780RLEEMGARMLHHHHHT-EEEaaaaavbbxa
1bup_A_1521bup   A161170AGTIAGLNVLHHHHTT-EEEaaaaavxbxa
1cb6_A_13961cb6   A14011410TAGKCGLVPVHHHHTT-EEEaaaaavxbxa
1cjx_A_271cjx   A2938IFEIMGFTKVHHHHTT-EEEaaaaavxbxa
1cli_B_11161cli   B11291138GCLQSGCSLVHHHHHT-EEEaaaaavxbxa
1dcp_A_101dcp   A1927NLRAVGWNE.HHHHHT-EE.aaaaagxbx.
1drk_*_1361drk   -148157AVAAHKFNVLHHHHHT-EEEaaaaalxxxa
1e42_A_8611e42   A867876KLQNNNVYTIHHHTTT-EEEaaaaalbxxa
1ehw_A_211ehw   A2736RFERRGFTLVHHHHTT-EEEaaaaavxbxa
1esc_*_411esc   -4857SLADKGITLDHHHTTT-EEEaaaaavxbxb
1ewk_A_2351ewk   A247256LAAQEGLCIAHHHHHT-EEEaaaaavxxxa
1f1u_A_1631f1u   A169178YLEDLGFRVSHHHHTT-EEEaaaaagxbxa
1f1x_A_1631f1x   A169178YLEDLGFRVTHHHHHT-EEEaaaaagxbxa
1f9z_A_131f9z   A2029YTKVLGMKLLHHHTT--EEEaaaaavxbxa
1g2q_A_1361g2q   A144153LVEQLEANLLHHHHTT-EEEaaaaavbbxa
1g3q_A_1451g3q   A157166VLKKAGLAILHHHHTT-EEEaaaaagxxxa
1g60_A_761g60   A8594YLVSKGMIFQHHHHTT-EEEaaaaavxbxa
1ghe_A_1361ghe   A140149FYSALAYTRVHHHHTT-EEEaaaaavxxxa
1gr0_A_2041gr0   A214223LFEDRGVQLDHHHHTT-EEEaaaaavbxxa
1gtm_A_2221gtm   A231240MSEDFGMKVVHHHTT--EEEaaaaavxbxa
1hc7_A_411hc7   A5765MFKETGHQN.HHHHTT-EE.aaaaavxbx.
1hlw_A_251hlw   A3140RYEKKGFVLVHHHHHT-EEEaaaaagxbxa
1hrd_A_2401hrd   A248257KLAELGAKAVHHHHTT-EEEaaaaavbbxa
1hsk_A_1911hsk   A191200IIQKEHLVVLHHHHTT-EEEaaaaalxbxa
1hwx_A_2541hwx   A262271YLHRFGAKCVHHHHTT-EEEaaaaavxbxa
1iho_A_2221iho   A232241ELNEKGFRADHHHHHT-EEEaaaaagxbpa
1iq7_A_3961iq7   A401410TAGVCGLVPVHHHHTT-EEEaaaaavxbwa
1js3_A_2191js3   A228237RDKAAGLIPFHHHHTT-EEEaaaaavxbxa
1k47_A_3061k47   A315324RWADLGIELLHHHHTT-EEEaaaaavxxxa
1kpg_A_2121kpg   A214223CASANGFTVTHHHTTT-EEEaaaaavbbxa
1lh0_A_11321lh0   A11391148IIQAHGATLAHHHHTT-EEEaaaaavxbxa
1lkd_A_1541lkd   A161170YTDVLGFQLSHHHTT--EEEaaaaavxbxa
1m1n_A_3641m1n   A366375AYEDLGMEVVHHHTTT-EEEaaaaavxbxa
1m1n_B_3731m1n   B382391FLLELGCEPVHHHHTT-EEEaaaaavxbwa
1m2x_A_1251m2x   A127136YFGKIGAKTYHHHHTT-EEEaaaaavxbOb
1m7y_A_1751m7y   A184193EAEKRNLRVKHHHHTT--EEaaaaavbxxa
1mkz_A_281mkz   A3645SAQEAGHHVVHHHHTT-EEEaaaaagxbxa
1mzv_A_1531mzv   A161170LVEASGAEVVHHHHTT-EEEaaaaavbbxa
1n71_A_1441n71   A146155FYEKLGYKIVHHHHTT-EEEaaaaavxbxa
1nhk_L_201nhk   L2635RFEEKGLKPVHHHHTT-EEEaaaaavxxwa
1nm2_A_1451nm2   A151160HLERLGLTPAHHHHTT-EEEaaaaagxbxa
1nri_A_421nri   A6372QAFQQGGRLIHHHHTT--EEaaaaavxbbb
1nsq_A_221nsq   A2837RFEQKGFKLVHHHHHT-EEEaaaaagxxxa
1ny1_A_2281ny1   A238247DLKKQGYTFKHHHHHT-EEEaaaaagxbbb
1oi2_A_3021oi2   A315324RCQQAGLTIEHHHHHT-EEEaaaaavxxxa
1ore_A_1341ore   A142151LLGRLQAEVLHHHHTT-EEEaaaaalxbxa
1p1j_A_3251p1j   A335344FLVDAGIKPVHHHHTT-EEEaaaaavxbwa
1pp7_U_801pp7   U8695NLRDLAFEQLHHHHTT-EEEaaaaavxbxa
1qb7_A_1531qb7   A161170LVEASDAVVVHHHHTT-EEEaaaaavbbxa
1qgu_A_3621qgu   A364373AYEDLGMEIIHHHHTT-EEEaaaaavxbxa
1qip_A_411qip   A4857YTRVLGMTLIHHHTT--EEEaaaaavxbxa
1qo0_A_1511qo0   A163172LYRQHGGTVLHHHTTT-EEEaaaaavxbxa
1rli_A_1301rli   A139148IFHFMGMSFKHHHHHT-EEEaaaaavxxxa
1rtq_A_1561rtq   A164173QYKSEGKNVVHHHHTT-EEEaaaaavxxxa
1spb_P_231spb   P2938VISEKGGKVQHHHHTT-EEEaaaaavxbpa
1tgo_A_5071tgo   A528537IEEKFGFKVLHHHTT--EEEaaaaavxbxa
1ufk_A_2241ufk   A230239AMAGAGFRPLHHHHTT-EEEaaaaavxbwa
1ukf_A_1531ukf   A161169VIEDAGFSL.HHHHTT-EE.aaaaavxbx.
2plh_*_222plh   -2533CAGVCRCKI.HHHHHTEEE.aaaaavbbb.
3mbp_*_1323mbp   -138147ELKAKGKSALHHHTTT-EEEaaaaavbbab
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1b33_N_331b33   N     CYCPHYCOCYANOBILIN Y - 33
1b33_N_331b33   N     CYCPHYCOCYANOBILIN E - 34
1b33_N_331b33   N     CYCPHYCOCYANOBILIN W - 36
1b33_N_331b33   N     CYCPHYCOCYANOBILIN F - 37
1b33_N_331b33   N     CYCPHYCOCYANOBILIN Q - 40
1b33_N_331b33   N     CYCPHYCOCYANOBILIN Q - 41
1b33_N_331b33   N     CYCPHYCOCYANOBILIN Q - 44
1bdb_*_1171bdb   *     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE Y - 119
1bdb_*_1171bdb   *     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE T - 140
1drk_*_1361drk   *     RIPRIBOSE(PYRANOSE FORM) A - 137
1drk_*_1361drk   *     RIPRIBOSE(PYRANOSE FORM) A - 138
1drk_*_1361drk   *     RIPRIBOSE(PYRANOSE FORM) R - 141
1e42_A_8611e42   A     MO5MAGNESIUM ION, 5 WATERS COORDINATED L - 868
1e42_A_8611e42   A     MO5MAGNESIUM ION, 5 WATERS COORDINATED Q - 869
1e42_A_8611e42   A     MO5MAGNESIUM ION, 5 WATERS COORDINATED N - 870
1e42_A_8611e42   A     MO5MAGNESIUM ION, 5 WATERS COORDINATED N - 871
1e42_A_8611e42   A     MO5MAGNESIUM ION, 5 WATERS COORDINATED N - 872
1e42_A_8611e42   A     MO5MAGNESIUM ION, 5 WATERS COORDINATED Y - 874
1e42_A_8611e42   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE I - 876
1e42_A_8611e42   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE A - 877
1e42_A_8611e42   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE R - 879
1ewk_A_2351ewk   A     GLUGLUTAMIC ACID Y - 236
1g3q_A_1451g3q   A     ADPADENOSINE-5'-DIPHOSPHATE N - 171
1g3q_A_1451g3q   A     ADPADENOSINE-5'-DIPHOSPHATE R - 172
1g3q_A_1451g3q   A     ADPADENOSINE-5'-DIPHOSPHATE Y - 173
1ghe_A_1361ghe   A     ACOACETYL COENZYME *A V - 136
1ghe_A_1361ghe   A     ACOACETYL COENZYME *A A - 137
1ghe_A_1361ghe   A     ACOACETYL COENZYME *A A - 139
1ghe_A_1361ghe   A     MSESELENOMETHIONINE F - 140
1ghe_A_1361ghe   A     ACOACETYL COENZYME *A F - 140
1ghe_A_1361ghe   A     MSESELENOMETHIONINE Y - 141
1ghe_A_1361ghe   A     ACOACETYL COENZYME *A Y - 141
1ghe_A_1361ghe   A     ACOACETYL COENZYME *A A - 143
1ghe_A_1361ghe   A     MSESELENOMETHIONINE L - 144
1ghe_A_1361ghe   A     ACOACETYL COENZYME *A L - 144
1ghe_A_1361ghe   A     MSESELENOMETHIONINE Y - 146
1ghe_A_1361ghe   A     MSESELENOMETHIONINE A - 157
1hsk_A_1911hsk   A     FADFLAVIN-ADENINE DINUCLEOTIDE I - 192
1hsk_A_1911hsk   A     FADFLAVIN-ADENINE DINUCLEOTIDE H - 196
1hsk_A_1911hsk   A     FADFLAVIN-ADENINE DINUCLEOTIDE L - 197
1hsk_A_1911hsk   A     FADFLAVIN-ADENINE DINUCLEOTIDE V - 198
1hsk_A_1911hsk   A     FADFLAVIN-ADENINE DINUCLEOTIDE V - 199
1hsk_A_1911hsk   A     FADFLAVIN-ADENINE DINUCLEOTIDE L - 200
1hwx_A_2541hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE N - 254
1hwx_A_2541hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE V - 255
1hwx_A_2541hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE G - 256
1hwx_A_2541hwx   A     GTPGUANOSINE-5'-TRIPHOSPHATE L - 257
1hwx_A_2541hwx   A     GTPGUANOSINE-5'-TRIPHOSPHATE H - 258
1hwx_A_2541hwx   A     GTPGUANOSINE-5'-TRIPHOSPHATE R - 261
1hwx_A_2541hwx   A     GTPGUANOSINE-5'-TRIPHOSPHATE Y - 262
1hwx_A_2541hwx   A     GTPGUANOSINE-5'-TRIPHOSPHATE R - 265
1hwx_A_2541hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE G - 274
1hwx_A_2541hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE E - 275
1js3_A_2191js3   A     PLPPYRIDOXAL-5'-PHOSPHATE T - 242
1kpg_A_2121kpg   A     MSESELENOMETHIONINE Q - 212
1kpg_A_2121kpg   A     MSESELENOMETHIONINE E - 213
1kpg_A_2121kpg   A     MSESELENOMETHIONINE C - 214
1kpg_A_2121kpg   A     MSESELENOMETHIONINE A - 215
1kpg_A_2121kpg   A     MSESELENOMETHIONINE F - 220
1lh0_A_11321lh0   A     OROOROTIC ACID L - 1154
1lkd_A_1541lkd   A     FE2FE (II) ION Q - 168
1lkd_A_1541lkd   A     FE2FE (II) ION L - 169
1lkd_A_1541lkd   A     BP62',6'-DICHLORO-BIPHENYL-2,6-DIOL I - 173
1lkd_A_1541lkd   A     BP62',6'-DICHLORO-BIPHENYL-2,6-DIOL M - 175
1lkd_A_1541lkd   A     P6GHEXAETHYLENE GLYCOL M - 175
1lkd_A_1541lkd   A     P6GHEXAETHYLENE GLYCOL K - 176
1m7y_A_1751m7y   A     PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID T - 198
1mkz_A_281mkz   A     MSESELENOMETHIONINE L - 33
1mzv_A_1531mzv   A     AMPADENOSINE MONOPHOSPHATE G - 153
1mzv_A_1531mzv   A     AMPADENOSINE MONOPHOSPHATE T - 154
1mzv_A_1531mzv   A     AMPADENOSINE MONOPHOSPHATE A - 155
1mzv_A_1531mzv   A     AMPADENOSINE MONOPHOSPHATE L - 176
1n71_A_1441n71   A     COACOENZYME A Y - 144
1n71_A_1441n71   A     COACOENZYME A E - 145
1n71_A_1441n71   A     COACOENZYME A F - 146
1n71_A_1441n71   A     COACOENZYME A Y - 147
1n71_A_1441n71   A     COACOENZYME A K - 149
1n71_A_1441n71   A     COACOENZYME A L - 150
1nri_A_421nri   A     MSESELENOMETHIONINE V - 43
1nri_A_421nri   A     MSESELENOMETHIONINE P - 44
1nri_A_421nri   A     MSESELENOMETHIONINE I - 47
1nri_A_421nri   A     MSESELENOMETHIONINE L - 51
1nri_A_421nri   A     MSESELENOMETHIONINE I - 54
1nri_A_421nri   A     MSESELENOMETHIONINE V - 58
1nri_A_421nri   A     MSESELENOMETHIONINE V - 62
1nri_A_421nri   A     MSESELENOMETHIONINE F - 65
1nri_A_421nri   A     MSESELENOMETHIONINE G - 69
1nri_A_421nri   A     MSESELENOMETHIONINE R - 70
1nri_A_421nri   A     MSESELENOMETHIONINE L - 71
1nri_A_421nri   A     MSESELENOMETHIONINE I - 72
1ny1_A_2281ny1   A     MSESELENOMETHIONINE N - 228
1ny1_A_2281ny1   A     MSESELENOMETHIONINE A - 231
1ny1_A_2281ny1   A     MSESELENOMETHIONINE L - 232
1ny1_A_2281ny1   A     MSESELENOMETHIONINE D - 233
1ny1_A_2281ny1   A     MSESELENOMETHIONINE A - 235
1ny1_A_2281ny1   A     MSESELENOMETHIONINE L - 239
1ore_A_1341ore   A     AMPADENOSINE MONOPHOSPHATE G - 134
1ore_A_1341ore   A     AMPADENOSINE MONOPHOSPHATE T - 135
1ore_A_1341ore   A     AMPADENOSINE MONOPHOSPHATE M - 136
1ore_A_1341ore   A     AMPADENOSINE MONOPHOSPHATE L - 159
1p1j_A_3251p1j   A     PO4PHOSPHATE ION Q - 325
1p1j_A_3251p1j   A     CRYPROPANE-1,2,3-TRIOL Q - 325
1p1j_A_3251p1j   A     PO4PHOSPHATE ION T - 326
1p1j_A_3251p1j   A     PO4PHOSPHATE ION K - 327
1p1j_A_3251p1j   A     PO4PHOSPHATE ION N - 350
1p1j_A_3251p1j   A     CRYPROPANE-1,2,3-TRIOL N - 350
1p1j_A_3251p1j   A     CRYPROPANE-1,2,3-TRIOL L - 352
1pp7_U_801pp7   U     ZNZINC ION V - 85
1qb7_A_1531qb7   A     CITCITRIC ACID T - 154
1qb7_A_1531qb7   A     MGMAGNESIUM ION T - 154
1qb7_A_1531qb7   A     MGMAGNESIUM ION A - 155
1qb7_A_1531qb7   A     ADEADENINE L - 176
1qip_A_411qip   A     GNBS-P-NITROBENZYLOXYCARBONYLGLUTATHIONE Q - 58
1qip_A_411qip   A     SEO2-MERCAPTOETHANOL Q - 58
1qip_A_411qip   A     GNBS-P-NITROBENZYLOXYCARBONYLGLUTATHIONE K - 59
1qip_A_411qip   A     SEO2-MERCAPTOETHANOL K - 59
1qip_A_411qip   A     GNBS-P-NITROBENZYLOXYCARBONYLGLUTATHIONE C - 60
1qip_A_411qip   A     SEO2-MERCAPTOETHANOL C - 60
1qip_A_411qip   A     SEO2-MERCAPTOETHANOL D - 61
1qip_A_411qip   A     GNBS-P-NITROBENZYLOXYCARBONYLGLUTATHIONE F - 62
1qip_A_411qip   A     SEO2-MERCAPTOETHANOL F - 62
1qo0_A_1511qo0   A     BMDBUTYRAMIDE Y - 152
1qo0_A_1511qo0   A     BMDBUTYRAMIDE P - 153
1rli_A_1301rli   A     PTPLATINUM (II) ION L - 132
1rli_A_1301rli   A     PTPLATINUM (II) ION Q - 135
1rtq_A_1561rtq   A     ZNZINC ION Q - 177
2plh_*_222plh   *     GOLGLYCEROL Q - 22
2plh_*_222plh   *     DISDISORDERED SOLVENT K - 23
2plh_*_222plh   *     ACTACETATE ION G - 27
2plh_*_222plh   *     DISDISORDERED SOLVENT V - 28
2plh_*_222plh   *     SBT2-BUTANOL V - 28
2plh_*_222plh   *     DISDISORDERED SOLVENT C - 29
2plh_*_222plh   *     SBT2-BUTANOL C - 29
2plh_*_222plh   *     ACTACETATE ION R - 30
2plh_*_222plh   *     SBT2-BUTANOL R - 30
2plh_*_222plh   *     DISDISORDERED SOLVENT K - 32
2plh_*_222plh   *     ACTACETATE ION K - 32
2plh_*_222plh   *     ACTACETATE ION I - 33
2plh_*_222plh   *     GOLGLYCEROL I - 33
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1e42_A_8611e42   A AC1MO5 BINDING SITE FOR CHAIN A SYMMETRY RELATED SUBUNITS CONTRIBUTE TO THE BINDING SITEQ - 869
1e42_A_8611e42   A AC1MO5 BINDING SITE FOR CHAIN A SYMMETRY RELATED SUBUNITS CONTRIBUTE TO THE BINDING SITEN - 870
1e42_A_8611e42   A AC1MO5 BINDING SITE FOR CHAIN A SYMMETRY RELATED SUBUNITS CONTRIBUTE TO THE BINDING SITEN - 872
1e42_A_8611e42   A AC1MO5 BINDING SITE FOR CHAIN A SYMMETRY RELATED SUBUNITS CONTRIBUTE TO THE BINDING SITEY - 874
1qip_A_411qip   A HD2HYDROPHOBIC SUBSTRATE BINDING POCKET AT DIMER INTERFACE.C - 60
1qip_A_411qip   A HD2HYDROPHOBIC SUBSTRATE BINDING POCKET AT DIMER INTERFACE.F - 62
1qo0_A_1511qo0   A LGABUTYRAMIDE BINDING SITEY - 152

Clusters included in this Subclass
CLUSTER: HE.1.42
CLUSTER: HE.2.12
CLUSTER: HE.2.146
CLUSTER: HE.2.59
CLUSTER: HE.3.187
CLUSTER: HE.3.22
CLUSTER: HE.4.181
CLUSTER: HE.4.350
CLUSTER: HE.4.45
CLUSTER: HE.5.63