ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 5.1.1

Subclass Accession number: 6
Subclass: 5.1.1
Type: AR beta-beta link
DB: ArchDB-KI

Number of loops: 22

Average sequence ID (%) : 46.6 +/- 2.4
Average RMSD (Å) : 0.44 +/- 0.17

Consensus geometry

d (Å): 15

delta (°): 0-45

theta (°): 45-90

rho (°): 90-135

Consensus Sequence:	hXDFGhApX
(φψ)-conformation:	bblaaapbb

Pattern:	[CILV]	{KQRY}	[ILV]	{ACGIV}	[DE]	[FLW]	[G]	{FLM}	{AV}	{EKRT}	x
Conservation:	-0.004	-0.488	0.425	-0.841	1.418	0.497	1.952	-0.756	-0.125	-0.857	-1.219

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1a6o_*_170	1a6o	-	171	181	LRLIDWGLAEF	EEE--GGG-EE	bbxblaaaxbx
1apm_E_180	1apm	E	180	190	IQVTDFGFAKR	EEE---TT-EE	xbxbvaaaxbb
1b6c_B_347	1b6c	B	347	357	CCIADLGLAVR	EEE---TT-EE	bbxblaaaxbb
1cdk_A_180	1cdk	A	180	190	IQVTDFGFAKR	EEE---TT-EE	xbxblaaaxbx
1cki_A_150	1cki	A	150	160	VYIIDFGLAKK	EEE---SS-EE	xbbbvaaapbx
1erk_*_161	1erk	-	161	171	LKICDFGLARV	EEE---TT-EE	xbxbvaaaxbx
1fot_A_224	1fot	A	224	234	IKITDFGFAKY	EEE---SS-EE	xbxblaaaxbx
1how_A_543	1how	A	546	556	IKIADLGNACW	EEE--GGG-EE	bbxblaaaxbb
1i09_B_195	1i09	B	196	206	LKLCDFGSAKQ	EEE---TT-EE	bbxbvaaaxbx
1ia8_A_144	1ia8	A	144	154	LKISDFGLATV	EEE---TT-EE	xbxbvaaaxbx
1ir3_A_1146	1ir3	A	1146	1156	VKIGDFGMTRD	EEE---TT-EE	xbxblaaaxbx
1jsu_A_141	1jsu	A	141	151	IKLADFGLARA	EEE---TT-EE	bbxbvaaaxbx
1k3a_A_1119	1k3a	A	1119	1129	VKIGDFGMTRD	EEE---TT-EE	xbxabaaaxbx
1koa_*_6079	1koa	-	6079	6089	LKLIDFGLTAH	EEE---TT-EE	xbxabaaapbx
1kob_A_190	1kob	A	190	200	VKIIDFGLATK	EEE---TT-EE	bbxabaaaxbx
1phk_*_163	1phk	-	163	173	IKLTDFGFSCQ	EEE---TT-EE	xbxblaaaxbx
1pme_*_163	1pme	-	163	173	LKICDFGLARV	EEE---TT-EE	bbxbvaaaxbx
1qpc_A_378	1qpc	A	378	388	CKIADFGLARL	EEE---TT-EE	bbxblaaaxbx
1tki_A_160	1tki	A	160	170	IKIIEFGQARQ	EEE---TT-EE	bbxabaaaxbx
1ydr_E_180	1ydr	E	180	190	IQVTDFGFAKR	EEE---TT-EE	xbxblaaaxbx
2csn_*_150	2csn	-	150	160	IYVVDFGMVKF	EEE---TT-EE	bbbbvaaaxbx
3lck_*_378	3lck	-	378	388	CKIADFGLARL	EEE---TT-EE	bbxblaaaxbx

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1apm_E_180	1apm	E	PHOPHEOPHYTIN A	F - 187
1apm_E_180	1apm	E	PHOPHEOPHYTIN A	K - 189
1jsu_A_141	1jsu	A	TPOPHOSPHOTHREONINE	L - 148
1jsu_A_141	1jsu	A	TPOPHOSPHOTHREONINE	R - 150
1phk_*_163	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	T - 166
1phk_*_163	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	D - 167
1phk_*_163	1phk	*	MNMANGANESE (II) ION	D - 167
1phk_*_163	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	F - 168
1phk_*_163	1phk	*	MNMANGANESE (II) ION	F - 168
1phk_*_163	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	G - 169
1phk_*_163	1phk	*	MNMANGANESE (II) ION	G - 169
1phk_*_163	1phk	*	ATPADENOSINE-5'-TRIPHOSPHATE	F - 170
1phk_*_163	1phk	*	MNMANGANESE (II) ION	F - 170
1ydr_E_180	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	T - 183
1ydr_E_180	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	D - 184
1ydr_E_180	1ydr	E	TPOPHOSPHOTHREONINE	F - 187
1ydr_E_180	1ydr	E	TPOPHOSPHOTHREONINE	K - 189
2csn_*_150	2csn	*	CKIN-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE	V - 153
2csn_*_150	2csn	*	CKIN-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE	D - 154
3lck_*_378	3lck	*	PTRO-PHOSPHOTYROSINE	L - 385
3lck_*_378	3lck	*	PTRO-PHOSPHOTYROSINE	R - 387
3lck_*_378	3lck	*	PTRO-PHOSPHOTYROSINE	L - 388

Bibliographic annotations

Loop	PDB	Chain	Annotation	Residue
1apm_E_180	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	T - 183
1apm_E_180	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	P-ATP BINDING RESIDUE(MG)	D - 184
1b6c_B_347	1b6c RefM.HUSE,Y.G.CHEN,J.MASSAGUE,J.KURIYAN. CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF BETA RECEPTOR IN COMPLEX WITH FKBP12 CELL(CAMBRIDGE,MASS.) v.96;425,1999	B	CATALYTIC RESIDUE	D - 351
1b6c_B_347	1b6c RefM.HUSE,Y.G.CHEN,J.MASSAGUE,J.KURIYAN. CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF BETA RECEPTOR IN COMPLEX WITH FKBP12 CELL(CAMBRIDGE,MASS.) v.96;425,1999	B	Mg ION BINDING RESIDUE	D - 351
1b6c_B_347	1b6c RefM.HUSE,Y.G.CHEN,J.MASSAGUE,J.KURIYAN. CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF BETA RECEPTOR IN COMPLEX WITH FKBP12 CELL(CAMBRIDGE,MASS.) v.96;425,1999	B	PHOSPHORYLATION SITE	R - 357
1cdk_A_180	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	ADENINE BINDING RESIDUE	T - 183
1cdk_A_180	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	CATALYTIC RESIDUE	D - 184
1cdk_A_180	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	INVARIANT RESIDUE (Mg COORDINATION)	D - 184
1cdk_A_180	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	ATP BINDING RESIDUE	F - 185
1cki_A_150	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	Mg ION BINDING RESIDUE	D - 154
1cki_A_150	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	P-ATP BINDING RESIDUE	D - 154
1ir3_A_1146	1ir3 RefS.R.HUBBARD. CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. v.16;5572,1997	A	DFG MOTIF (ACTIVATION LOOP)	D - 1150
1ir3_A_1146	1ir3 RefS.R.HUBBARD. CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. v.16;5572,1997	A	P-ATP BINDING RESIDUE	D - 1150
1jsu_A_141	1jsu RefA.A.RUSSO,P.D.JEFFREY,A.K.PATTEN,J.MASSAGUE,N.P.PAVLETICH. CRYSTAL STRUCTURE OF THE P27KIP1 CYCLIN-DEPENDENT-KINASE INHIBITOR BOUND TO THE CYCLIN A-CDK2 COMPLEX NATURE v.382;325,1996	A	P27 PROTEIN BINDING RESIDUE	A - 144
1jsu_A_141	1jsu RefA.A.RUSSO,P.D.JEFFREY,A.K.PATTEN,J.MASSAGUE,N.P.PAVLETICH. CRYSTAL STRUCTURE OF THE P27KIP1 CYCLIN-DEPENDENT-KINASE INHIBITOR BOUND TO THE CYCLIN A-CDK2 COMPLEX NATURE v.382;325,1996	A	P27 PROTEIN BINDING RESIDUE	A - 144
1kob_A_190	1kob RefB.KOBE,J.HEIERHORST,S.C.FEIL,M.W.PARKER,G.M.BENIAN,K.R.WEISS,B.E.KEMP. GIANT PROTEIN KINASES: DOMAIN INTERACTIONS AND STRUCTURAL BASIS OF AUTOREGULATION EMBO J. v.15;6810,1996	A	Mg ION BINDING RESIDUE	D - 194
1kob_A_190	1kob RefB.KOBE,J.HEIERHORST,S.C.FEIL,M.W.PARKER,G.M.BENIAN,K.R.WEISS,B.E.KEMP. GIANT PROTEIN KINASES: DOMAIN INTERACTIONS AND STRUCTURAL BASIS OF AUTOREGULATION EMBO J. v.15;6810,1996	A	ACTIVE SITE RESIDUE	L - 197

Clusters included in this Subclass

CLUSTER: AR.5.0