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Information on SUBCLASS 12.1.3
Subclass Accession number: 8041
Subclass: 12.1.3 PSSM
Type: HA beta-beta hairpin
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4.21 (>50 %)  
GO : GO:0004252 (>50 %)  GO:0008236 (>50 %)  
SCOP : 50493 (>75 %)  50494 (>75 %)  50514 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 22.2 +/- 17.9
Average RMSD (Å) : 0.333 +/- 0.058

Consensus geometry
d (Å): 5 delta (°): 90-135 theta (°): 135-180 rho (°): 0-45
Consensus Sequence: hXpXXhpXXTpXXDhX
(φψ)-conformation: bbpaapbaaalplpbb
Pattern: xx[FI][KPS][HY][NPS]x[FY][DNT][KP][ADE][T][RY]xx[D][ILV][AK][LV][IL][KQR]
Conservation:-1.003-0.933-0.038-0.7211.649-0.650-0.9331.443-0.3680.407-0.6501.6090.036-1.215-1.1452.2450.126-0.4220.1050.4000.056
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1g2l_A_861g2l   A88108VVIKHNRFTKETYDFDIAVLREEEE-TT--TTT-TT--EEEEbbbbxaaxbaaavxlxbbbbb
1orf_A_851orf   A87107KEFPYPCYDPATREGDLKLLQEEEE-TT--TTT-TT--EEEEbxbxpaapbaaavxlxbbxbx
2hlc_A_872hlc   A87107RIISHSMFNPDTYLNDVALIKEEEE-TT-BTTTTBT--EEEEbbbxpaaxbaaavxlxbbbbx
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1g2l_A_861g2l   A     T87[(1-{2[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-1-METHYL-1H-BENZOIMIDAZOL-5-YL}-CYCLOPROPYL)-PYRIDIN-2-YL-METHYLENEAMINOOXY]-ACETIC ACID ETHYL ESTER K - 97
1g2l_A_861g2l   A     T87[(1-{2[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-1-METHYL-1H-BENZOIMIDAZOL-5-YL}-CYCLOPROPYL)-PYRIDIN-2-YL-METHYLENEAMINOOXY]-ACETIC ACID ETHYL ESTER E - 98
1g2l_A_861g2l   A     T87[(1-{2[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-1-METHYL-1H-BENZOIMIDAZOL-5-YL}-CYCLOPROPYL)-PYRIDIN-2-YL-METHYLENEAMINOOXY]-ACETIC ACID ETHYL ESTER T - 99
1g2l_A_861g2l   A     T87[(1-{2[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-1-METHYL-1H-BENZOIMIDAZOL-5-YL}-CYCLOPROPYL)-PYRIDIN-2-YL-METHYLENEAMINOOXY]-ACETIC ACID ETHYL ESTER Y - 100
1g2l_A_861g2l   A     T87[(1-{2[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-1-METHYL-1H-BENZOIMIDAZOL-5-YL}-CYCLOPROPYL)-PYRIDIN-2-YL-METHYLENEAMINOOXY]-ACETIC ACID ETHYL ESTER D - 103
1orf_A_851orf   A     DPND-PHENYLALANINE R - 99
1orf_A_851orf   A     MAIDEOXO-METHYLARGININE D - 102
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
2hlc_A_872hlc   A CTANULLD - 102

Clusters included in this Subclass
CLUSTER: HA.12.10