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Information on SUBCLASS 2.1.2
Subclass Accession number: 8188
Subclass: 2.1.2 PSSM
Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 57

Average sequence ID (%) : 10.9 +/- 14.1
Average RMSD (Å) : 0.637 +/- 0.245

Consensus geometry
d (Å): 9 delta (°): 90-135 theta (°): 90-135 rho (°): 45-90
Consensus Sequence: XXchXh
(φψ)-conformation: aalpbb
Pattern: x[adeknqrst][adeknqrst]x[adegknqrs][acfgikltv]x[acfgilmpvwy]x
Conservation:-0.1640.2260.114-0.7242.298-0.438-0.497-0.816-1.000
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a0i_*_1541a0i   -156164IVESGEDCDHHHH---EEaaaavpxxx
1ayl_*_4181ayl   -429437MQAAGAQAYHHHHT-EEEaaaavxbbb
1bgx_T_7641bgx   T772780LEEMGARMLHHHHT-EEEaaaavbbxa
1byb_*_3261byb   -332340LSRHHAILNHHHTT-EEEaaaalxxxx
1cjx_A_271cjx   A3038FEIMGFTKVHHHTT-EEEaaaavxbxa
1cjx_A_2851cjx   A288296LQARGILLDHHHHT-EEEaaaavxbbb
1dci_A_2181dci   A224232LTFTARKMMHHHH--EEEaaaalxxbx
1dpj_A_2251dpj   A232239NAEIGAKK.HHHHT-EE.aaaavbbx.
1dqw_A_741dqw   A8189SAKYNFLLFHHHHT-EEEaaaavbxbb
1dyn_A_1021dyn   A112119FLRAGVYP.HHHTT-EE.aaaavxxx.
1e39_A_3441e39   A349357AENAGGALKHHHTT--EEaaaavxxbb
1eag_A_2281eag   A235243IKAFNGKLTHHHTT-EEEaaaavxbxb
1eov_A_2421eov   A262269LATKKFTE.HHHTT-EE.aaaavxbx.
1esw_A_3471esw   A353361RDRFGLPGMHHHTT--EEaaaavxxbb
1f2v_A_601f2v   A6775ALKAGAPILHHHTT--EEaaaagpxbx
1fa2_A_3611fa2   A372380GWKEYIDVAHHHTT--EEaaaalbxbb
1ffv_C_1251ffv   C129137SIAVEAHFVHHHTT-EEEaaaavxbbx
1gdh_A_1831gdh   A186193EASYQATF.HHHHT-EE.aaaalxxx.
1gu7_A_3081gu7   A311319YIFKNFTSAHHHS--EEEaaaalxbbb
1hpg_A_2311hpg   A235242LSAYGVTV.HHHHT-EE.aaaavbbx.
1htr_B_2301htr   B234241LQATGAQE.HHHHT-EE.aaaavxbx.
1hzd_A_2301hzd   A236244LIFSARVLDHHHHT-EEEaaaalxbxb
1idp_A_511idp   A5159RSFLDKLWEHHHHS-EEEaaaalbbba
1ii2_A_3921ii2   A403411MQKHNSRVWHHHHT-EEEaaaalxxbb
1itu_A_2341itu   A240248VKQTDSLVMHHHHT-EEEaaaavxbbx
1j4a_A_861j4a   A8997AKELGFQITHHHTT-EEEaaaavxbbb
1j6u_A_891j6u   A97105LKREKKEEFHHHH---EEaaaalbxbb
1j71_A_2281j71   A235243ARIVGATWDHHHHT-EEEaaaavxbxb
1jeh_A_841jeh   A106114FKKNKVTYYHHHHT-EEEaaaalbxxx
1jvb_A_2811jvb   A284291ITLSEIQF.HHHHT-EE.aaaalxbb.
1k6w_A_2551k6w   A265273LKMSGINFVHHHHT-EEEaaaavxbbb
1kgq_A_951kgq   A98105FQKEGFRV.HHHHT-EE.aaaavbbb.
1knw_A_1711knw   A178186IQRHHLQLVHHHTT-EEEaaaalxbxa
1ko7_A_41ko7   A816VERFELEMIHHHHT-EEEaaaalxxxa
1kol_A_3231kol   A326334GWAKSHSFHHHHTT-EEEaaaalxbbb
1l6j_A_2621l6j   A262270YDTDDRFGFHHHH--EEEaaaaUbbbx
1l6j_A_3201l6j   A320328YDRDKLFGFHHHH--EEEaaaalbbbx
1lh0_A_11661lh0   A11711179ERDYGCKVIHHHH--EEEaaaalbbxx
1ltm_*_2921ltm   -295302LAAAGLTP.HHHTT-EE.aaaagbbx.
1lya_B_2411lya   B248256QKAIGAVPLHHHHT-EEEaaaavxbxa
1n62_C_1251n62   C129137MQCLGAAYEHHHHT-EEEaaaavxbxx
1ny1_A_2281ny1   A239247LKKQGYTFKHHHHT-EEEaaaagxbbb
1o4s_A_1811o4s   A191199AKKRNFYIIHHHHT-EEEaaaalbxbb
1ogo_X_921ogo   X92100EPSIGLNMAHHHHT-EEEaaaavpbbb
1onf_A_761onf   A98106LSKDKVDLYHHHTT-EEEaaaavxxxb
1pb1_A_2381pb1   A250257REEFGGEL.HHHH--EE.aaaavxbp.
1qo8_A_2481qo8   A260268AKEQGIDTRHHHTT--EEaaaavxxxx
1qop_A_31qop   A1119LNDRREGAFHHHTT--EEaaaalbxxb
1qq4_A_1841qq4   A188195LSQYGLSL.HHHHT-EE.aaaavxbx.
1qrp_E_2251qrp   E232239QSDIGASE.HHHTT-EE.aaaavxbx.
1ses_A_3551ses   A357365ARRANLRYRHHHHT-EEEaaaavbbbb
1sgp_E_2311sgp   E235242LVAYGVSV.HHHHT-EE.aaaavbbx.
1uet_A_2641uet   A271279VEERGTAVFHHHHT-EEEaaaavbbbb
1ujp_A_31ujp   A1018ARSEGRAALHHHTTB-EEaaaavbxxb
2apr_*_2282apr   -235242ARAYGASD.HHHHT-EE.aaaavxbx.
2nac_A_2272nac   A230237EKELNLTW.HHHHT-EE.aaaalxbx.
3cms_*_2253cms   -232240QQAIGATQNHHHHT-EEEaaaagbbxx
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ayl_*_4181ayl   *     ATPADENOSINE-5'-TRIPHOSPHATE N - 440
1byb_*_3261byb   *     GLCGLUCOSE F - 341
1dci_A_2181dci   A     EDO1,2-ETHANEDIOL R - 218
1dci_A_2181dci   A     EDO1,2-ETHANEDIOL V - 221
1dci_A_2181dci   A     EDO1,2-ETHANEDIOL N - 222
1dci_A_2181dci   A     EDO1,2-ETHANEDIOL F - 226
1e39_A_3441e39   A     FADFLAVIN-ADENINE DINUCLEOTIDE D - 344
1e39_A_3441e39   A     FADFLAVIN-ADENINE DINUCLEOTIDE G - 345
1e39_A_3441e39   A     FADFLAVIN-ADENINE DINUCLEOTIDE V - 348
1fa2_A_3611fa2   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE E - 382
1ffv_C_1251ffv   C     FADFLAVIN-ADENINE DINUCLEOTIDE H - 125
1ffv_C_1251ffv   C     FADFLAVIN-ADENINE DINUCLEOTIDE P - 126
1gu7_A_3081gu7   A     GOLGLYCEROL L - 310
1gu7_A_3081gu7   A     GOLGLYCEROL Y - 311
1gu7_A_3081gu7   A     GOLGLYCEROL I - 312
1gu7_A_3081gu7   A     GOLGLYCEROL F - 313
1gu7_A_3081gu7   A     GOLGLYCEROL K - 314
1gu7_A_3081gu7   A     GOLGLYCEROL N - 315
1gu7_A_3081gu7   A     GOLGLYCEROL F - 316
1gu7_A_3081gu7   A     GOLGLYCEROL A - 319
1gu7_A_3081gu7   A     GOLGLYCEROL G - 320
1j6u_A_891j6u   A     MSESELENOMETHIONINE R - 89
1j6u_A_891j6u   A     MSESELENOMETHIONINE Y - 92
1j71_A_2281j71   A     EOHETHANOL Q - 228
1j71_A_2281j71   A     EOHETHANOL D - 232
1j71_A_2281j71   A     EOHETHANOL W - 242
1jvb_A_2811jvb   A     MSESELENOMETHIONINE F - 291
1kgq_A_951kgq   A     NPI2-AMINOPIMELIC ACID R - 104
1knw_A_1711knw   A     PLPPYRIDOXAL-5'-PHOSPHATE H - 189
1n62_C_1251n62   C     FADFLAVIN-ADENINE DINUCLEOTIDE M - 125
1n62_C_1251n62   C     FADFLAVIN-ADENINE DINUCLEOTIDE L - 138
1ny1_A_2281ny1   A     MSESELENOMETHIONINE N - 228
1ny1_A_2281ny1   A     MSESELENOMETHIONINE A - 231
1ny1_A_2281ny1   A     MSESELENOMETHIONINE L - 232
1ny1_A_2281ny1   A     MSESELENOMETHIONINE D - 233
1ny1_A_2281ny1   A     MSESELENOMETHIONINE A - 235
1ny1_A_2281ny1   A     MSESELENOMETHIONINE L - 239
1o4s_A_1811o4s   A     PLPPYRIDOXAL-5'-PHOSPHATE D - 201
1pb1_A_2381pb1   A     GOLGLYCEROL L - 257
1qo8_A_2481qo8   A     FADFLAVIN-ADENINE DINUCLEOTIDE S - 248
1qo8_A_2481qo8   A     HEMPROTOPORPHYRIN IX CONTAINING FE P - 250
1qo8_A_2481qo8   A     FADFLAVIN-ADENINE DINUCLEOTIDE I - 253
1qop_A_31qop   A     IPLINDOLE-3-PROPANOL PHOSPHATE F - 22
1ujp_A_31ujp   A     CITCITRIC ACID Y - 21
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1gu7_A_3081gu7   A BC3SO4 BINDING SITE FOR CHAIN AS - 309
1gu7_A_3081gu7   A AC6GOL BINDING SITE FOR CHAIN AK - 314
1qop_A_31qop   A IPLSUBSTRATE ANALOG BOUND TO THE ALPHA ACTIVE SITE.F - 22

Clusters included in this Subclass
CLUSTER: HE.1.6
CLUSTER: HE.2.7
CLUSTER: HE.3.11