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Information on SUBCLASS 3.1.2
Subclass Accession number: 8298
Subclass: 3.1.2 PSSM
Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 75

Average sequence ID (%) : 14.6 +/- 15.4
Average RMSD (Å) : 0.892 +/- 0.196

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 135-180 rho (°): 270-315
Consensus Sequence: pXGhpXh
(φψ)-conformation: aagpabb
Pattern: xxx[acfilmvy][adeknqrst][adekqrst]x[adgknr][acfilpvwy][dehknpqrst]x[acfgilmpvwy]xx
Conservation:-0.576-0.418-0.7670.3840.3420.297-0.7353.045-0.2390.439-0.9720.145-0.667-0.279
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a0c_A_2011a0c   A216229VDYAKEIGFEGQFLHHHHHHTT--SEEEaaaaaaavxaxxxb
1a0e_A_2011a0e   A216229VDYAKRIGFTGQFLHHHHHHTT--SEEEaaaaaaalxaxxxb
1a3w_A_341a3w   A3749LVALRKAGLNIVR.HHHHHHHT--SEE.aaaaaaaNxaxbx.
1ado_A_1301ado   A134147CAQYKKDGADFAKWHHHHHHTT--EEEEaaaaaaagxabbbb
1ajs_A_1421ajs   A144157NGVFTTAGFKDIRSHHHHHHTT-S-EEEaaaaaaagxabbbb
1azw_A_851azw   A93106ERLRTHLGVDRWQVHHHHHHTT-SSEEEaaaaaaavxabbxb
1b5t_A_1881b5t   A195208RDRCVSAGIDVEIIHHHHHHTT--S-EEaaaaaaavxabxxx
1bj4_A_1831bj4   A187200EENARLFHPKLIIAHHHHHHH--SEEEEaaaaaaavxabbxb
1bxb_A_1531bxb   A165178AAYAEDQGYGYRFAHHHHHHHT---EEEaaaaaaavxaxbxb
1bxb_A_2641bxb   A271284VDLLESSGYQGPRHHHHHHHTT--S-EEaaaaaaavxaxxbx
1c30_A_6231c30   A627639LEIVRIEKPKGVI.HHHHHHH--SEEE.aaaaaaalxabbx.
1chu_A_2901chu   A298311DHEMKRLGADCMFLHHHHHHHT-S-EEEaaaaaaavxabbbb
1coz_A_771coz   A7891KQDIIDHNIDVFVMHHHHHHTT-SEEEEaaaaaaalxabbbb
1cqz_A_3081cqz   A316329VTFLDKLGIPQAVFHHHHHHHT---EEEaaaaaaavxabbbx
1ctt_*_2731ctt   -277290SATLKALGCHSIDRHHHHHHHT---EEEaaaaaaavbabbbb
1cvl_*_611cvl   -7083KQVLAATGATKVNLHHHHHHH--S-EEEaaaaaaavxabbbb
1cz1_A_2001cz1   A211224YNSLRQTGSVTPVIHHHHHHTT----EEaaaaaaavxaxpxb
1doz_A_2351doz   A240253RDLFEQKGYQAFVYHHHHHHH--SEEEEaaaaaaavpabbbb
1e0t_A_3551e0t   A363376VETAEKLDAPLIVVHHHHHHTT-SBEEEaaaaaaavxabbxb
1eua_A_771eua   A8093LAEVTEAGAQFAISHHHHHHHT-S-EEEaaaaaaagpabbbb
1ex9_A_531ex9   A6578EEIVALSGQPKVNLHHHHHHH--S-EEEaaaaaNavbabbbx
1f2j_A_1401f2j   A144157AKKYYAMGCRFCKWHHHHHHTT--EEEEaaaaaaagxabbbb
1fdj_A_11301fdj   A11341147CAQYKKDGVDFGKWHHHHHHTT--EEEEaaaaaaavxabbbb
1fxp_A_11351fxp   A11381151VEKLKFGGAKEIYLHHHHHHTT-SSEEEaaaaaaagxabbbb
1hlg_A_1301hlg   A136149DFIVKKTGQKQLHYHHHHHHH--S-EEEaaaaaaavxabbbb
1hv9_A_351hv9   A4053IDAANELGAAHVHLHHHHHHHT-S-EEEaaaaaaagpabbxx
1i5e_A_1381i5e   A144157IDALKKRGAKSIKFHHHHHHTT---EEEaaaaaaavxabbbb
1igw_A_741igw   A7790ALQQAKAGIEAVYLHHHHHHHT---EEEaaaaaaagxabxbb
1iic_A_1831iic   A191204TRRVNKCDIWHALYHHHHHTTT---EEEaaaaaaavbabbbb
1iyk_A_1891iyk   A197210TRRVNKQNIWQALYHHHHHTTT---EEEaaaaaaavbabbbb
1j0h_A_3031j0h   A314327TYWIREFDIDGWRLHHHHHHH---EEEEaaaaaaavxabbxx
1jhd_A_1801jhd   A184197RNEIKEHGWSKVVAHHHHHHHT-SSEEEaaaaaaavxaxbbb
1jys_A_521jys   A6073TLLLEHCKPDVIINHHHHHHH--SEEEEaaaaaaalxabbbb
1k4g_A_561k4g   A5669PETVRATGADIILGHHHHHHTT-S-EEEaaaaaaagxabbbb
1k4m_A_171k4m   A2437ETLANLIGLTRVTIHHHHHHHT-S-EEEaaaaaaaSbabbxx
1k8q_A_1301k8q   A136149DFILKKTGQDKLHYHHHHHHH--S-EEEaaaaaaavxabbxx
1ka9_F_331ka9   F3750ARAYDEAGADELVFHHHHHHHT-S-EEEaaaaaaagxabbbb
1kbi_A_2591kbi   A266279VKNVEKLGVKALFVHHHHHHHT-S-EEEaaaaaaagxabbbx
1lar_A_17871lar   A17971810HKTKEQFGQDGPITHHHHHHTT--S-EEaaaaaaalxaxxxx
1ldc_B_2591ldc   B266279VKNVEKLGVKALFVHHHHHHTT---EEEaaaaaaavxabbbx
1ldc_B_4151ldc   B418431VLKALCLGAKGVGLHHHHHHHT-S-EEEaaaaaaagxabbbb
1ldn_A_1101ldn   A121134VESVMASGFQGLFLHHHHHHHT--SEEEaaaaaaavpabxbb
1lwj_A_291lwj   A2942VSYLKELGIDFVWLHHHHHHTT--EEEEaaaaaaavxabbbb
1lyx_A_801lyx   A8093AEIAKDLNIEYVIIHHHHHHTT--EEEEaaaaaaavxabbxb
1m6y_A_851m6y   A8699DFLLKTLGIEKVDGHHHHHHTT-S-EEEaaaaaaavbabbab
1m7x_A_3801m7x   A391404LYWIERFGIDALRVHHHHHHS---EEEEaaaaaaavpabbbx
1m8p_A_1781m8p   A182195RVHFDKLGWSRVVAHHHHHHTT--SEEEaaaaaaavxaxbxx
1mdl_*_2021mdl   -209221SQALQQEGVTWIE.HHHHHHHT-S-EE.aaaaaaagxabbb.
1mxs_A_891mxs   A92104FAAVEAAGAQFVV.HHHHHHHT-SSEE.aaaaaaagpabbb.
1nnl_A_1571nnl   A163176KLLKEKFHFKKIIMHHHHHHH--S-EEEaaaaaaalpabbbb
1nul_A_401nul   A4457ALLARELGIRHVDTHHHHHHHT---EEEaaaaaaavxaxbbb
1nyr_A_3951nyr   A407420IDVYKDFGFEDYSFHHHHHHTT---EEEaaaaaaavxabbbx
1o60_A_1501o60   A152165VEKIEECGNDKIILHHHHHHTT---EEEaaaaaaavbaxbbb
1ojx_A_981ojx   A98111VEEAVSLGASAVGYHHHHHHTT-SEEEEaaaaaaavxabbbb
1ovm_A_71ovm   A1225LDRLTDCGADHLFGHHHHHHTT--EEEEaaaaaaagxabbxe
1p1h_B_2161p1h   B228241QNFKEENALDKVIVHHHHHHHT-S-EEEaaaaaaalbabbbb
1p1j_A_2161p1j   A228241QNFKEENALDKVIVHHHHHHTT-S-EEEaaaaaaalxabbbb
1p6w_A_1551p6w   A166179LWLKSDLGFDAWRLHHHHHHH---EEEEaaaaaaagpabbbx
1pkl_A_3761pkl   A385398VNSVYETKAKAMVVHHHHHHHT-S-EEEaaaaaaalxabbbb
1pox_A_131pox   A1831IKVLEAWGVDHLYGHHHHHHTT--EEEEaaaaaaavxabbbe
1qsg_A_451qsg   A4962EEFAAQLGSDIVLQHHHHHHTT---EEEaaaaaaavbabbbx
1qsm_A_1041qsm   A113125YDEADKLGTPSVY.HHHHHHTT---EE.aaaaaaavbaxbb.
1qtr_A_881qtr   A96109ERLREMAGVEQWLVHHHHHHHT-SSEEEaaaaaaavbabbxb
1rpx_C_251rpx   C2942VKAIEQAGCDWIHVHHHHHHTT---EEEaaaaaaagxabbxb
1srr_A_361srr   A4053LDIVTKERPDLVLLHHHHHHH--SEEEEaaaaaaalxabbbb
1srr_A_871srr   A90103IQESKELGALTHFAHHHHHHHT---EEEaaaaaaagpabbbb
1un7_A_2071un7   A210221LSDAAKAGASHM..HHHHHHTT--EE..aaaaaaagxabb..
1ute_A_2061ute   A206219LPLLTTHKVTAYLCHHHHHHTT-SEEEEaaaaaaalxabbbb
1vjs_*_291vjs   -2941SAYLAEHGITAVW.HHHHHHTT--EEE.aaaaaaavxabbx.
1ykf_A_1771ykf   A183196VAGAKLRGAGRIIAHHHHHHTT-SSEEEaaaaaaavxaxbbb
2cst_A_1422cst   A144157NSVFMDAGFKDIRTHHHHHHTT---EEEaaaaaaagxabbbb
2scu_A_562scu   A5770REAVAATGATASVIHHHHHHH---EEEEaaaaaaavpabbbb
4tmk_A_164tmk   A2437VETLEQLGIRDMVFHHHHHHTT---EEEaaaaaaavbaxbbb
6mht_A_1016mht   A105118ARIVREKKPKVVFMHHHHHHH--SEEEEaaaaaaalxabbbb
7a3h_A_467a3h   A5063KWLRDDWGINVFRAHHHHHHT---EEEEaaaaaaavxabbbx
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1a3w_A_341a3w   A     PGA2-PHOSPHOGLYCOLIC ACID R - 49
1ado_A_1301ado   A     13P1,3-DIHYDROXYACETONEPHOSPHATE K - 146
1ado_A_1301ado   A     13P1,3-DIHYDROXYACETONEPHOSPHATE R - 148
1ajs_A_1421ajs   A     PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID N - 142
1ajs_A_1421ajs   A     PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID H - 143
1coz_A_771coz   A     CTPCYTIDINE-5'-TRIPHOSPHATE V - 90
1coz_A_771coz   A     CTPCYTIDINE-5'-TRIPHOSPHATE M - 91
1coz_A_771coz   A     CTPCYTIDINE-5'-TRIPHOSPHATE G - 92
1doz_A_2351doz   A     MO6MAGNESIUM ION, 6 WATERS COORDINATED Q - 236
1eua_A_771eua   A     PYRPYRUVIC ACID I - 92
1eua_A_771eua   A     PYRPYRUVIC ACID S - 93
1ex9_A_531ex9   A     OCPOCTYL-PHOSPHINIC ACID 1,2-BIS-OCTYLCARBAMOYLOXY-ETHYL ESTER R - 56
1ex9_A_531ex9   A     OCPOCTYL-PHOSPHINIC ACID 1,2-BIS-OCTYLCARBAMOYLOXY-ETHYL ESTER H - 81
1fdj_A_11301fdj   A     2FP1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM) K - 1146
1fdj_A_11301fdj   A     2FP1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM) R - 1148
1hv9_A_351hv9   A     UD1URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE V - 54
1i5e_A_1381i5e   A     U5PURIDINE-5'-MONOPHOSPHATE G - 138
1i5e_A_1381i5e   A     U5PURIDINE-5'-MONOPHOSPHATE S - 139
1i5e_A_1381i5e   A     U5PURIDINE-5'-MONOPHOSPHATE A - 140
1igw_A_741igw   A     MO3MAGNESIUM ION, 3 WATERS COORDINATED Y - 89
1igw_A_741igw   A     PYRPYRUVIC ACID Y - 89
1igw_A_741igw   A     PYRPYRUVIC ACID L - 90
1iic_A_1831iic   A     MYATETRADECANOYL-COA T - 183
1iic_A_1831iic   A     MYATETRADECANOYL-COA P - 184
1iic_A_1831iic   A     MYATETRADECANOYL-COA L - 186
1iic_A_1831iic   A     MYATETRADECANOYL-COA I - 187
1iic_A_1831iic   A     MYATETRADECANOYL-COA I - 190
1iic_A_1831iic   A     MYATETRADECANOYL-COA T - 191
1iic_A_1831iic   A     MYATETRADECANOYL-COA V - 194
1iic_A_1831iic   A     MYATETRADECANOYL-COA N - 195
1iic_A_1831iic   A     MYATETRADECANOYL-COA I - 199
1iic_A_1831iic   A     MYATETRADECANOYL-COA W - 200
1iic_A_1831iic   A     MYATETRADECANOYL-COA H - 201
1iic_A_1831iic   A     MYATETRADECANOYL-COA A - 202
1iic_A_1831iic   A     MYATETRADECANOYL-COA Y - 204
1iic_A_1831iic   A     MYATETRADECANOYL-COA T - 205
1iic_A_1831iic   A     MYATETRADECANOYL-COA A - 206
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA A - 189
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA P - 190
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA L - 192
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA I - 193
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA I - 196
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA T - 197
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA V - 200
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA N - 201
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA I - 205
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA W - 206
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA Q - 207
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA A - 208
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA Y - 210
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA T - 211
1iyk_A_1891iyk   A     MIM[CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL] PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE T - 211
1iyk_A_1891iyk   A     MYATETRADECANOYL-COA G - 212
1iyk_A_1891iyk   A     MIM[CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL] PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE G - 212
1jys_A_521jys   A     ADEADENINE S - 76
1jys_A_521jys   A     ADEADENINE A - 77
1jys_A_521jys   A     ADEADENINE G - 78
1k4g_A_561k4g   A     AIQ2,6-DIAMINO-8-(1H-IMIDAZOL-2-YLSULFANYLMETHYL)-3H-QUINAZOLINE-4-ONE L - 68
1k4m_A_171k4m   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE G - 18
1k4m_A_171k4m   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE H - 19
1k4m_A_171k4m   A     CITCITRIC ACID H - 19
1k4m_A_171k4m   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE P - 22
1k4m_A_171k4m   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE I - 38
1k8q_A_1301k8q   A     BOGB-OCTYLGLUCOSIDE H - 152
1k8q_A_1301k8q   A     C11UNDECYL-PHOSPHINIC ACID BUTYL ESTER H - 152
1kbi_A_2591kbi   A     MPD2-METHYL-2,4-PENTANEDIOL R - 259
1kbi_A_2591kbi   A     MPD2-METHYL-2,4-PENTANEDIOL T - 262
1kbi_A_2591kbi   A     MPD2-METHYL-2,4-PENTANEDIOL D - 263
1kbi_A_2591kbi   A     MPD2-METHYL-2,4-PENTANEDIOL V - 266
1kbi_A_2591kbi   A     FMNFLAVIN MONONUCLEOTIDE T - 280
1ldc_B_4151ldc   B     FMNFLAVIN MONONUCLEOTIDE G - 430
1ldc_B_4151ldc   B     FMNFLAVIN MONONUCLEOTIDE L - 431
1ldn_A_1101ldn   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE N - 113
1ldn_A_1101ldn   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE I - 116
1ldn_A_1101ldn   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE S - 119
1ldn_A_1101ldn   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE I - 120
1ldn_A_1101ldn   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE V - 135
1m6y_A_851m6y   A     MSESELENOMETHIONINE I - 100
1mdl_*_2021mdl   *     MGMAGNESIUM ION E - 221
1mdl_*_2021mdl   *     SMN(S)-MANDELIC ACID E - 221
1nnl_A_1571nnl   A     CACALCIUM ION K - 158
1nnl_A_1571nnl   A     CACALCIUM ION G - 178
1nyr_A_3951nyr   A     ATPADENOSINE-5'-TRIPHOSPHATE R - 421
1o60_A_1501o60   A     MSESELENOMETHIONINE N - 150
1o60_A_1501o60   A     MSESELENOMETHIONINE I - 151
1o60_A_1501o60   A     MSESELENOMETHIONINE V - 152
1o60_A_1501o60   A     MSESELENOMETHIONINE E - 153
1o60_A_1501o60   A     MSESELENOMETHIONINE N - 160
1o60_A_1501o60   A     MSESELENOMETHIONINE I - 164
1o60_A_1501o60   A     MSESELENOMETHIONINE L - 165
1o60_A_1501o60   A     MSESELENOMETHIONINE C - 166
1o60_A_1501o60   A     MSESELENOMETHIONINE D - 167
1p1h_B_2161p1h   B     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE W - 243
1p1j_A_2161p1j   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE W - 243
1qsm_A_1041qsm   A     ACOACETYL COENZYME *A A - 104
1qsm_A_1041qsm   A     ACOACETYL COENZYME *A G - 105
1qsm_A_1041qsm   A     ACOACETYL COENZYME *A G - 106
1qsm_A_1041qsm   A     ACOACETYL COENZYME *A K - 107
1srr_A_361srr   A     CACALCIUM ION D - 54
1ykf_A_1771ykf   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE P - 177
1ykf_A_1771ykf   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE V - 178
1ykf_A_1771ykf   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 179
1ykf_A_1771ykf   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE V - 197
2cst_A_1422cst   A     PLPPYRIDOXAL-5'-PHOSPHATE H - 143
2scu_A_562scu   A     COACOENZYME A I - 70
4tmk_A_164tmk   A     T5AP1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE K - 16
4tmk_A_164tmk   A     T5AP1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE T - 17
4tmk_A_164tmk   A     T5AP1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE T - 18
4tmk_A_164tmk   A     T5AP1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE A - 19
4tmk_A_164tmk   A     T5AP1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE R - 39
6mht_A_1016mht   A     4SC4'-THIO-2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE GROUP E - 119
6mht_A_1016mht   A     SAMS-ADENOSYLMETHIONINE E - 119
6mht_A_1016mht   A     4SC4'-THIO-2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE GROUP N - 120
6mht_A_1016mht   A     4SC4'-THIO-2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE GROUP V - 121
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1azw_A_851azw   A ASACTIVE-SITE.G - 100
1mdl_*_2021mdl   * MTLSITE MTL CONSTITUTES THE DIRECT METAL ION LIGANDS.E - 221

Clusters included in this Subclass
CLUSTER: HE.3.20
CLUSTER: HE.4.31
CLUSTER: HE.5.3
CLUSTER: HE.6.155